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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

As part of a study of prevention of atherosclerosis precursors mass examinations were performed in two districts of Moscow. In the intervention district, the sample included 1123 pupils aged 11-12 years (544 boys, 579 girls), in the control district 1963 pupils (963 boys, 1000 girls) were examined. Repeat checks were performed one, 2 and 3 years after initial examination (blood pressure, body mass and height, skinfold thickness above m. triceps and below the scapula). The prevention programme addressed the whole population, with special emphasis on obese children (instruction about diet and correct feeding habits, body mass control) and their social microenvironment. Favourable results were registered, in terms of blood pressure and skinfold thickness reduction, during the first 2 years in boys; in girls diastolic BP dropped in the 1st year only, skinfold thickness was reduced in the first 2 years. Multiple regression analysis confirmed that the observed changes could be ascribed to the effect of the preventive programme.
Cor Vasa 1990
PMID:Results of a three-year trial of arterial hypertension prevention in a population of children aged 11-15 years by overweight control. 208 76

The authors present new approaches to assessment of various aspects of receptor metabolism for low density lipoproteins in patients with atherosclerosis: the ability of lipoproteins to interact with cell receptors in culture in the presence of nonfractionated serum; analysis of the genetically determined number of LDL receptors on culture cells, and the in vivo lipoprotein uptake in the liver. The ability of apo B-containing lipoproteins in patients with atherosclerosis to interact effectively with cell receptors was confirmed, the activity of LDL receptors on cells in cultures from patients with hypercholesterolaemia was analysed, and a decrease in 99mTc-labelled LDL uptake in the liver of patients with the heterozygous form of familial hypercholesterolaemia was demonstrated. The above approaches could be useful in the choice of individual treatment of clinically manifest atherosclerosis and evaluation of therapeutic efficacy.
Cor Vasa 1990
PMID:New methods of diagnosing receptor metabolism disturbances of low density lipoproteins. 222 77

As part of a programme designed to determine precursors of arterial hypertension and atherosclerosis in children and adolescents, a cross-sectional study involving the groups of families whose children had different baseline arterial pressure levels was conducted. An association between the level of arterial pressure in the children and the blood pressure levels and prevalence of cardiovascular diseases in their first-degree relatives was found. The most informative signs for decreased and increased arterial blood pressure levels in children were identified. The findings should be taken into account when selecting groups of children who require close medical surveillance.
Cor Vasa 1990
PMID:Factors determining arterial blood pressure in childhood. 228 85

The spectrum of HLA antigens was studied in 619 control subjects and 357 patients with atherosclerosis of various localization (coronary, cerebral, and lower limbs arteries). Comparative analysis has shown both agreement and differences to exist between patient groups depending on atherosclerosis localization. Significant differences were also found in the level of various lipid components. A relationship between HLA antigens and lipid markers was demonstrated, especially between locus B and C antigens and HDL cholesterol level. The authors believe the findings can be utilized to determine predisposition to atherosclerosis of various localization.
Cor Vasa 1990
PMID:Comparison of HLA antigen spectrum in atherosclerosis of various localization. 235 Sep 65

The effect of 7-mono-hydroxyethylrutoside and its combination with acetylsalicylic acid was evaluated in a controlled clinical trial, performed in 105 patients with obliterative atherosclerosis of the lower limbs, and using non-invasive measurement of peripheral haemodynamic parameters--blood flow during reactive hyperaemia and ankle systolic blood pressure. Patients, randomized into three groups, received either placebo or 7-mono-hydroxyethylrutoside alone or in combination with acetylsalicylic acid for 12 months. The placebo group showed a decrease in maximum calf blood flow and a decrease in ankle systolic pressure. Administration of 7-mono-hydroxyethylrutoside did not lead to any significant changes in systolic pressure but there was a decrease in the maximum calf blood flow. There were no statistically significant changes in patients receiving the 7-mono-hydroxyethylrutoside and acetylsalicylic acid combination who, by contrast, showed a tendency to increased values of the parameters measured.
Cor Vasa 1989
PMID:The effect of hydroxyethylrutoside and its combination with acetylsalicylic acid in patients with obliterative atherosclerosis. 266 43

The authors compare the prevalence of risk factors of atherosclerosis and ischaemic heart disease (dyslipoproteinaemia, elevated arterial pressure, overweight, smoking, low physical activity) in representative samples of 11- and 14-year old school-children in Moscow, Novosibirsk and Tallin. The number of pupils subjected to medical examination totalled 3369; the respondence rate was 87-92%. There appeared a number of regional differences: the study in Moscow showed the highest prevalence of elevated arterial pressure and overweight, in Novosibirsk - hypertriglyceridaemia, in Tallin - hypercholesterolaemia. The most unfavourable situation was registered in school-children in Novosibirks. The authors conclude that when planning preventive measures among the population it is necessary to take into account regional specificities and differences in the intensity of risk factors in children populations.
Cor Vasa 1988
PMID:Epidemiological characteristics of dyslipoproteinaemia and certain other risk factors of atherosclerosis and ischaemic heart disease in 11- and 14-year children in different climatogeographic zones. Results of a cooperative study. 326 84

In order to reduce precursors of atherosclerosis, an intervention trial was carried out in pupils aged 10-11 years at the time of inclusion into the study (5th graders). The main goal of the study was to encourage health-promoting behaviour patterns--mostly present in the schoolchildren at that time--such as non-smoking, a negative attitude toward future smoking, a high level of physical activity including sports. The study design included dietary measures aimed at lowering blood pressure and total cholesterol values. Follow-up examination, performed at an interval of 2 years, revealed the following results: significantly lower mean total cholesterol values in girls attending the intervention schools; a significantly lower prevalence of smoking and a decrease in the number of casual smokers--compared with data obtained in the 5th grade--in the intervention schools; a negative attitude towards smoking and the extent of sport activities remained at the level of the 5th grade in the intervention schools.
Cor Vasa 1987
PMID:Atherosclerosis precursors in schoolchildren--results of a two-year intervention study. 343 46

In 120 middle aged male patients with stable angina pectoris and coronarographically documented CAD all examined serum lipid markers differed significantly in comparison with 30 male subjects with vertebro-cardial syndrome and negative coronaro-angiogram (p less than 0.001). The low mean overall coronary score values (4.017 +/- 2.376) reflect the low extent of the coronary atherosclerosis. The coronary score values were significantly positively correlated to the serum levels of cholesterol, triglyceride, LDL-cholesterol, VLDL-cholesterol and negatively correlated to the serum concentration of HDL-cholesterol and HDL-cholesterol/total cholesterol ratios in all examined subjects (CAD and n-CAD groups) (p less than 0.001). In contrast, no significant correlation between coronary score and the examined lipid markers was exhibited in the CAD group of patients when comparing subjects with low and middle coronary score values. According to our results the ratio HDL-cholesterol/total cholesterol represents the best single indicator of the presence and also discriminator of the severity of the coronary athero-sclerosis in the patients with stable angina pectoris.
Cor Vasa 1987
PMID:Lipid markers, coronary score and coronary artery disease of stable angina pectoris type. 362 49

Correlation between the severity of coronary atherosclerosis, thrombosis and sudden cardiac death was examined in 721 autopsied cases. Severe coronary atherosclerosis with stenosis was found in most of them; however a similar grade of atherosclerosis was discovered in patients with ischaemic heart disease not dying suddenly. Acute coronary thrombosis in the studied subjects was diagnosed post mortem in about 20 percent of those who died suddenly. Other studies indicate frequencies between 4-93%. There was no consistent time dependence.
Cor Vasa 1986
PMID:Atherosclerosis of coronary arteries, coronary heart disease and sudden coronary death. 373 91

In a series of 1,216 Kaunas school-children aged 10-15 years, a study was conducted of risk factors for atherosclerosis and ischaemic heart disease (elevated blood pressure, overweight, reduced physical activity, and smoking), and of the influence of nonmedicamentous measures on the risk factors' level. After three-years intensive health education concentrated on school-children and their parents, the number of smokers and subjects with reduced physical activity among school-children significantly decreased and the number of overweight school-children also dropped in the preventive intervention district, compared to the control district. The study showed the need for regular examinations of school-children for detecting the presence of risk factors, and the effectiveness of primary non-medicamentous prevention of atherosclerosis and ischaemic heart disease, carried out from school-age.
Cor Vasa 1985
PMID:Preventive study of atherosclerosis and ischaemic heart disease risk factors among Kaunas school-children. 405 13


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