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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Effects of partial inhibition of aortic histamine formation on aortic albumin uptake and lipid deposition were examined in male, New Zealand white rabbits maintained on Purina Rabbit Chow containing 0.5% cholesterol for a 2-week period. Aortic histamine synthesis was inhibited by partial inhibition of aortic histidine decarboxylase (HD) through administration of alpha-hydrazinohistidine (alpha-HH, MK785, Regis Chemical Co., 25 mg/kg, i.p. at 12-h intervals). Additional rabbits were maintained on either the cholesterol diet or on Purina Rabbit Chow without cholesterol. Results indicate that administration of alpha-HH for the 2-week period produced a 31% reduction (P less than 0.05) in aortic HD activity in those rabbits maintained on the cholesterol diet, and that concurrently there was a 51% reduction in aorta albumin uptake (P less than 0.025) and a 63% reduction in the extent of oil red O staining. By regression analysis a significant correlation coefficient (r = 0.71, P less than 0.005) was obtained between the aortic albumin uptake and the aortic histamine forming capacity (HFC) in rabbits maintained on this cholesterol diet. These findings indicate that the aortic HD system may be an important enzymatic coupler involved in vascular permeability alterations occurring early in the atherogenic sequence.
Atherosclerosis 1979 Dec
PMID:Relationship between inhibition of aortic histamine formation, aortic albumin permeability and atherosclerosis. 51 43

Time-related observations of myointimal hyperplasia in precocious male steelhead trout maintained in the laboratory suggest that regression of arterial lesions occurs. The most severe myointimal hyperplasia in these trout was observed from June through August during which time the mean lesion rank of the sampled fish reached 2.3 on a ranking scale of 0-5. This time is concomitant with the period of increasing gonadal mass in the strain studied. However, there was no correlation between gonad size and arteriosclerotic lesion severity. Mean lesion severity of fish examined from September through November was approximately one-half that reported for the previous periods. During the September-November period gonadal weights in this strain of fish decreased. Although no statistical correlations could be derived it is suggested that in steelhead trout, changes in myointimal hyperplasia lesion severity are associated with changing reproductive patterns.
Atherosclerosis 1979 Dec
PMID:Time study of coronary myointimal hyperplasia in precocious male steelhead trout, Salmo gairdneri. 51 44

Aortic cross-circulation between Holtzman rat littermates was employed to investigate the possible role of a blood-borne factor from the small intestine in the regulation of hepatic cholesterol synthesis. Experimental pairs, consisting of a normal rat and a distal 50% small bowel excluded partner, demonstrated significantly increased combined hepatic cholesterol synthesis when compared to control pairs, consisting of two normal rats, both at 3 and 5 days following parabiosis. This difference was accounted for by increased hepatic cholesterol synthesis in the normal rat in each experimental pair. Neither weight loss nor differences in dietary intake contributed to this effect. Whole blood cholesterol in the common circulation of both experimental and control pairs was lowered; while hepatic cholesterol content was transiently increased, at 3 but not 5 days following parabiosis. Thus, the intestinal bypassed rat stimulates, or releases inhibition of, hepatic cholesterol synthesis in a non-bypassed parabiotic partner. The mechanism for this phenomenon has yet to be defined.
Atherosclerosis 1979 Dec
PMID:Increased hepatic cholesterol synthesis in normal rats by cross-circulation with ileal bypassed partners. 51 45

Two experiments are described. In the first, 3 pairs of groups of 20 female White Carneau pigeons were fed on diets containing 0.5%, 1% or 2% cholesterol. Birds in one group from each pair were exposed to 150 ppm carbon monoxide (CO) for 6 h on 5 days of each week for 52 weeks, sufficient to raise their carboxyhaemoglobin (COHb) levels to approximately 10%, while those in the other group were sham-exposed under similar conditions. In the second experiment, 3 groups of 40 female pigeons were each fed on a diet containing 1% cholesterol, one group being exposed to CO to give COHb levels of 20%, one to give COHb levels of 10% and one being sham exposed. In addition, 20 birds in the second experiment were fed on the 1% cholesterol diet but were neither exposed to CO nor sham-exposed. Cholesterol enriched diets caused mean plasma cholesterol values in each group to rise sharply within 4 weeks of starting them, but the levels reached were as high with diets containing 0.5% cholesterol as for diets containing 1% or 2% added cholesterol. Exposure to CO increased plasma and aortic cholesterol levels, though this increase was only statistically significant for aortic levels in the second experiment. In both experiments combined exposure to the 1% cholesterol diet and CO resulted in a significant decrease in aortic triglyceride content. The incidence and severity of coronary artery atherosclerosis was associated with increasing dietary cholesterol. It was also associated with exposure to CO in birds given 0.5% or 1%, but not 2%, dietary cholesterol; the increase in birds given 1% was related to the dose of CO. Possible mechanisms are discussed for this effect of CO, which is not found in normally fed birds.
Atherosclerosis 1979 Dec
PMID:Atherogenesis in the White Carneau pigeon. Further studies of the role of carbon monoxide and dietary cholesterol. 51 46

Serum lipoproteins, separated by preparative ultracentrifugation and the activity of the plasma enzyme lecithin: cholesterol acyltransferase (LCAT) have been measured in insulin-dependent diabetics, non-insulin-dependent diabetics and in age-matched non-diabetic controls. In the insulin-dependent diabetics, mean total serum cholesterol and high density lipoprotein cholesterol (HDL-C) concentrations were significantly higher than in controls. Non-insulin-dependent diabetics had significantly raised total triglycerides and cholesterol, but HDL-C levels were essentially normal. The increased low density lipoprotein cholesterol (LDL-C) in both diabetic groups was statistically significant in men. A methodological study of HDL separation techniques was carried out to facilitate interpretation of these findings. Mean LCAT activity, by a method reflecting combined enzyme and substrate effects was significantly increased in these diabetic groups. The results confirm recent reports of a raised HDL-C in those insulin-dependent diabetics who are prone to coronary heart disease.
Atherosclerosis 1979 Dec
PMID:Lipoproteins and plasma cholesterol esterification in normal and diabetic subjects. 51 47

Vascular casts of the rat aorta were made using modified Batson's No. 17 anatomical corrosion compound. The outline of the silver-stained endothelial cell boundaries were clearly visible on the cast when examined using both scanning electron and light microscopy. The physical properties of the injectate were determined. The exothermic nature of the polymerization of the injectate did not grossly damage the endothelial cells. A method was developed for recovery, without damage, of the arterial tissue surrounding the cast. The technique of vascular casting appears to be a powerful tool for the study of the arterial endothelium which avoids shrinkage artifacts and maintains 3-dimensional geometry.
Atherosclerosis 1979 Dec
PMID:Vascular casting. A new method for the study of the arterial endothelium. 51 48

The relationship between arterial calcification and serum estradiol levels was studied in 72 postmenopausal female and 59 male subjects. In both sexes, subjects with iliac artery calcification had rather lower serum estradiol levels (8.4 +/- 1.4 pg/ml in the females, and 19.2 +/- 2.5 pg/ml in the males) than controls (16.1 +/- 1.6 pg/ml in the females, and 29.7 +/- 2.4 pg/ml in the males). The bone mineral content of females with iliac artery calcification (0.44 +/- 0.02 g/cm2) was lower than controls (0.52 +/- 0.01 g/cm2); a positive correlation between serum estradiol levels and bone mineral content was found in the females. However, bone mineral content did not significantly differ between males with and without arterial calcification (0.67 +/- 0.03 g/cm2 in the former, and 0.65 +/- 0.02 g/cm2 in the latter). These results indicate that arterial calcification and increased bone resorption are both individual results of estrogen deficiency.
Atherosclerosis 1979 Dec
PMID:Low serum estradiol levels in subjects with arterial calcification. 51 49

Segments of human thoracic aorta were maintained in long-term explant culture for 18 weeks in serum-supplemented medium. The aortas were grossly normal in appearance, and random samples fixed for light microscopy prior to culture revealed a normal morphology. The intima contained no more than five layers of smooth muscle cells. After 7 days in culture, the intima was noticeably thicker than the uncultured segments. The increased thickness was due to proliferating smooth muscle cells and production of extracellular material. After several months in culture, extracellular material consisting of collagen and flocculent material was present in areas resembling atherosclerotic fibrous plaques. A peripheral growth, which formed around the explant, was composed of fibroblastlike cells and added to the overall thickness of the intima. However, aortic segment maintained for up to 2 months in serum-free culture medium showed no cellular proliferation. This study demonstrates that changes resembling early stages of atherosclerosis occur in human aortas maintained in explant culture using routine culture procedures.
In Vitro 1979 Dec
PMID:Long-term culture of human aortas. Development of atherosclerotic-like plaques in serum-supplemented medium. 53 10

In the hearts of 100 unselected adult autopsies (average age 65 years) the coronary arteries and their major branches were investigated. After opening the lumen, the vessels were measured, and the location of all sclerotic lesions was identified, including fatty streaks. The frequency of distribution of advanced sclerotic changes was similar to that of lipid and fibrolipid plaques. 1003 major coronary artery branches were studied. 25% of them showed sclerotic changes in contrast to 92% in the coronary arteries themselves. There was a good correlation between the sclerotic lesions in the coronary arteries and their branches: no changes were found in the branches the corresponding stems of which were unchanged. In contrast to that, sclerotic branches nearly always originated from sclerotic areas of the coronary arteries. Branches of the left anterior descending artery were more frequently affected by atherosclerosis (39%) than branches of the right coronary artery (17%). Contrary to the right coronary artery sclerotic changes of the proximal branches of the left anterior descending and the left circumflex artery were significantly more frequent than sclerotic lesions of the distal branches. The frequency of sclerotic lesions in the branches was similar to that in the coronary arteries; the proximal part was more frequently affected than the distal one. In addition, the peripheral decreasing frequency of sclerotic changes, which was found to be more pronounced in the left coronary arteries than in the right one, showed a similar behaviour in the corresponding branches. Our investigations indicate the vessel's diameter to be a significant (but not the only) factor in atherosclerosis development in coronary arteries and their branches. In case of a corresponding size of lumen, the frequency of sclerotic changes in the coronary arteries was approximately the same as in their branches.
Z Kardiol 1979 Dec
PMID:[Localization of sclerotic lesions in the coronary arteries and their epicardial branches (author's transl)]. 54 3

Twelve cases of hypopituitarism (Sheehan's syndrome, pituitary adenoma, idiopathic) associated with hyperlipidemia (type IIb in general) are reported. It is suggested that: 1 - Growth hormone deficiency seems to have a protective effect against atherosclerosis in hyperlipidemia because there are no cardiovascular signs in 10 cases with a history of growth hormone deficiency lasting from 5 to 57 years and a patent hyperlipidemia (lasting a mean of 23 years), and there is stabilisation or improvement of ischemic signs in 2 other cases. 2 - Lipid abnormalities are frequently seen in hypopituitarism even after thyroid replacement therapy. 3 - The hyperlipidemia can be familial or can result from growth hormone deficiency alone.
Nouv Presse Med 1979 Dec 03
PMID:[Hypopituitarism and hyperlipidemia. Protective effect of growth hormone deficiency against atherosclerosis (author's transl)]. 54 16


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