Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of dimethyl sulfoxide (DMSO) on cholesterol-induced atherosclerosis in the rabbit was investigated. Two groups of rabbits were studied: a Control group which received regular chow and an Experimental group which received an atherogenic diet containing 1% cholesterol. DMSO was either omitted or added to the drinking water of both groups in amounts of 2, 4, 5 and 6%. After 3 months all animals were autopsied; the thoracic aorta was examined for atheromatous lesions and the abdominal aorta assayed for total cholesterol content. As expected the thoracic aortas of all rabbits in the Control group were free of atheromatous lesions. With the exception of one rabbit in the Experimental group, all rabbits on the atherogenic diet which did not receive DMSO had extensive aortic lesions covering 82 +/- 5% of the surface area of the thoracic aorta. Aortic lesions were inhibited by about 50% in rabbits on 2% (dose, 1.5 g/kg) DMSO and virtually absent in the majority of rabbits on 4 (dose, 3.5 g/kg), 5 (dose, 5.5 g/kg) and 6% (dose, 9.1 g/kg) DMSO. The food intake of rabbits on the atherogenic diet was not suppressed by DMSO. Changes in the cholesterol content of the abdominal aortas paralleled the presence or absence of lesions in the thoracic aorta. Blood cholesterol levels were greatly elevated in all rabbits on the atherogenic diet and not lowered by DMSO. In conclusion, cholesterol induced atherosclerosis in the rabbit was inhibited by DMSO. This action of DMSO was independent of the hypercholesterolemia and not due to a suppression of food intake. DMSO may provide a useful probe for investigating the underlying mechanism(s) in the development of cholesterol induced atherosclerosis.
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PMID:Inhibition of cholesterol-induced atherosclerosis in rabbits by dimethyl sulfoxide. 368 2

In 260 male farmers (40-45 years) divided into 9 groups from different areas in France and Britain, coagulation, platelet aggregation, lipemia, fatty acids from plasma lipids and platelet phospholipids were determined in relation to the food intake evaluated by recall, weighing and chemical analysis of the diet. The clotting activity of platelets and their response to thrombin aggregation was significantly correlated on an individual basis with the intake of saturated fatty acids both in subsamples as well as in the whole study. Serum cholesterol was also significantly correlated with saturated fats but only on a group basis or on the totality of the study. Calcium, linolenic acid and alcohol in the diet were inversely related to certain platelet functions. Linoleic acid was inversely related to serum cholesterol and triglycerides. Dietary saturated fats were associated, with an increase in the platelet phospholipids not in saturated fatty acids but in 20:3 (n-9), known to promote platelet aggregation to thrombin, with a decrease in platelet cholesterol, also apparently regulating platelet functions. The present studies indicate that dietary saturated fats, calcium (hard water) and alcohol, influence platelet behaviour in a way strictly parallel to their known effect on coronary heart disease.
Atherosclerosis 1986 Apr
PMID:Nutrients, platelet function and composition in nine groups of French and British farmers. 370 72

Aging in the nasal tissues produces anatomical and physiological changes in the elderly. The elderly have a generalized decrease in body water content of 7%, and with the degeneration of mucus-secreting cells, the effectiveness of the mucociliary system is reduced with frequent symptoms of nasal stuffiness. The fragmentation and weakening of the cartilage of the septum also causes airflow changes contributing to nasal stuffiness. The elderly also experience hormonal and metabolic changes which affect the physiologic nasal function. Epistaxis is relatively common in the elderly, and aging changes in the vascular system such as atherosclerosis contribute to the severity of epistaxis. The majority of nosebleeds in the elderly originate anteriorly due to dryness and local trauma.
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PMID:Rhinological disorders in the elderly. 374 17

Biochemical analysis of the extracellular matrix of human aortas was performed on samples of ascending and descending aortas affected by atherosclerosis in comparison with a control group of nonatherosclerotic aortas. Ulcerated or heavily calcified atheromas were excised and excluded from the analysis in order to differentiate biochemical alterations leading to the formation of atheromas from those due to complications of already formed atheromas. Our results show that the development of atheromas brings about an extensive destruction of elastic fibers and muscular cells, and their place is occupied by other components of the extracellular matrix, most notably, collagen, non-uronic sugars, water, and lipids, which were found significantly increased.
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PMID:Aortic connective tissue in atherosclerotic aorta--a biochemical study. 376 64

Amorphin--24-vicyanoside (C34H4O16(2)H2O)--in a dose of 10 mg/kg orally decreases the content of cholesterol, total lipids, atherogenic lipoproteids in the blood and organs of intact rats and rats with endogenous or ethanol hyperlipemia, inhibits the development of experimental atherosclerosis in rabbits induced by the combination of risk factors (cholesterol + glucose + hypodynamia), decreases the content of lipids in the blood and organs (especially in aorta), prevents the development of morphological manifestations of the aorta atherosclerosis.
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PMID:[Hypolipidemic, hypocholesterolemic and antisclerotic action of the rotenoid glycoside amorphin]. 381 47

This study used quantitative electron microscopy to assess ultrastructural features of endothelial injury occurring with exposure to nicotine. Fourteen mice were given nicotine in their drinking water for 5 weeks. The dose (5 mg/kg body wt/day) was equivalent to a human smoking 50-100 cigarettes/day. A control group of mice was unexposed to nicotine over the same period. Stereological analysis of electron micrographs of endothelium from both groups revealed that the nicotine-exposed endothelium showed greater cytoplasmic vacuolation, mitochondrial swelling and subendothelial oedema than the control endothelium. In addition the intercellular cleft morphology was significantly (P less than 0.005) less complex than in the control endothelium. This difference in cleft morphology suggests the nicotine-exposed endothelium is more permeable than the control endothelium. The ultrastructural differences noted in this study are indicative of endothelial damage, and provide structural evidence to support the hypothesis that nicotine contributes to the pathogenesis of arterial disease in smokers.
Atherosclerosis 1987 Jan
PMID:The effect of nicotine on aortic endothelium. A quantitative ultrastructural study. 382 69

The development of a model of chronic myocardial ischemic injury (MII) in rabbits by administering increasing doses of isoproterenol (ISO) is described. Repeated s.c. injections of increasing doses of ISO (0.5 mg/kg, on day 1 to 15.5 mg/kg, on day 15) resulted in an increase in serum glucose, free fatty acids and creatine phosphokinase. Examination of hearts from ISO-treated rabbits revealed marked hypertrophy of the left ventricle and an increase in total water content. Biochemical analysis showed an increase in left ventricular hydroxyproline and a decrease in ATP and glycogen content following ISO-treatment. Ion measurements revealed extensive accumulation of Na and Ca, with the Ca being preferentially accumulated in the mitochondria. Measurement of subcellular organelle marker enzymes showed decreases in the sarcolemmal Na+-K+-stimulated (ouabain-sensitive), mitochondrial (azide-sensitive) and sarcoplasmic reticulum ATPase activities in the ISO-treated animals. Analysis of lysosomal enzyme activities in myocardial homogenates showed significant decreases in the latency of N-acetyl-beta-glucosaminidase and cathepsin D. The above biochemical alterations in ISO-induced MII generally parallel changes previously seen in the rabbit following acute coronary artery ligation. The present model allows the study of MII uncomplicated by some uncertainties arising from the surgical or anesthetic procedures employed in acute "open-chest" preparations and would permit long-term follow-up studies of pharmacological interventions. The susceptibility of the rabbit to experimental atherosclerosis should allow the development of an experimental model of MII which more closely approximates the clinical situation.
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PMID:Myocardial ischemic injury induced by isoproterenol in the rabbit: biochemical and chemical alterations. 385 Jul 74

The various factors which determine brain weight and volume of the lateral ventricles were studied in an autopsy material of 467 cases. The material consisted of 64 men and 17 women between 45-54 years and 196 men and 190 women between 70-79 years. The weights of the cerebral hemispheres and of the cerebellum and brainstem were determined separately. The volume of the lateral ventricles was determined by weighing the hemispheres with and without water in the lateral ventricles. The recorded variables were age, sex, body length, body weight, cerebral atherosclerosis, Alzheimer changes and alcoholism. Cerebral atherosclerosis and Alzheimer changes were quantitated by morphometric methods. The results were analysed by conventional and multivariate statistical methods. The following observations were made: In normal brains there was a significant correlation between the weight of the supra- and infratentorial parts. Similarly, there was a significant correlation between the size of the lateral ventricles and the weight of the cerebral hemispheres. Women had smaller brains than men even when the difference in body length was taken into account. The difference was approximately 110-115 g for the whole brain after correction for other variables. Women had also smaller lateral ventricles than men, but this difference was in proportion to the smaller size of their hemispheres. There was a physiologic decline in brain weight and a widening of the lateral ventricles with increasing age. This shrinkage probably started after the age of 55. There was a clear correlation between body length and brain weight. The estimated increase in brain weight was approximately 3 g per cm body length. There was a decreasing brain weight and an increasing ventricular size with a decreasing body mass index. This shows that emaciation leads to a decrease in brain size. Severe Alzheimer changes caused a statistically significant enlargement of the lateral ventricles both in men and women. There was a general trend for brain weight reduction in cases with severe Alzheimer changes but the decrease was statistically significant only in old women, and it could not be entirely excluded that the weight reduction in part was due to a concurrent emaciation rather than to the Alzheimer changes per se. In the majority of the cases, the Alzheimer changes were mild and had probably progressed slowly with age. A few cases had very severe changes.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:Variations in the size of the human brain. Influence of age, sex, body length, body mass index, alcoholism, Alzheimer changes, and cerebral atherosclerosis. 388 32

The effect of intraperitoneal injections of potassium chromate on prevention and regression of atherosclerosis was observed in New Zealand White rabbits. In rabbits fed a 1% cholesterol diet for 90 days, potassium chromate injection was not associated with a significant difference in weight, serum cholesterol, total cholesterol content per 8.5 cm aorta, cholesterol content per gram of aorta or percent intima covered with plaque compared to controls. Similarly, significant differences were not seen in rabbits fed a 1% cholesterol diet for 90 days followed by 60 days of potassium chromate or distilled water injections and a standard diet. These results are in keeping with recent studies suggesting a more limited role for chromium in a variety of lipid-related disorders.
Atherosclerosis 1986 Jan
PMID:Effects of potassium chromate on atherosclerosis prevention and regression in rabbits. 394 21

The purpose of this investigation was to determine changes in the flow field due to mild atherosclerosis using a main coronary artery casting of man with maximum obstruction of about 50% by area. Local pressure changes were measured using six pressure tap holes drilled flush to the wall along the casting. The test fluid used was a 33% sugar-water solution to simulate the viscosity of blood. Flow visualization results were obtained by injecting blue dye slowly through the pressure tap holes. The local pressure measurements clearly demonstrated a significant Reynolds number effect. At physiological Reynolds numbers of 80-710, a local pressure rise was observed downstream of the mild atherosclerotic constriction of 50% because of momentum changes. The flow visualization study indicated that the critical Reynolds number for flow separation to occur in the divergent region of this coronary casting was about 330. Flow separation has been implicated in the genesis of atherosclerosis but there is little information on the extent of flow separations in vivo in arteries of man. These results are believed to be important in obtaining a quantitative relation between coronary morphology and the fluid dynamic consequences of mild diffuse disease especially under conditions of maximum cardiac demand i.e., higher coronary flow rates, and thus Reynolds numbers associated with space and/or atmospheric flight.
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PMID:Effect of simulated hyperemia on the flow field in a mildly atherosclerotic coronary artery casting of man. 398


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