Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Murine resident peritoneal macrophages (MRPM), incubated with beta-very low density lipoprotein (beta-VLDL), modify the beta-VLDL, producing an increase in the mobility of the lipoprotein. The modification does not result in an increase of thiobarbituric acid-reactive substances (TBARS) in the lipoprotein, and is not inhibited by butylated hydroxyanisole (BHA), EDTA, removal of copper and iron from the medium, or by diphenyliodonium (DPI), suggesting that the mechanism of modification is independent of oxidation. Macrophage conditioned medium performed the modification in the absence of cells, and phenylmethylsulphonyl fluoride (PMSF) inhibited beta-VLDL modification, whereas other protease inhibitors did not, suggesting that a secreted neutral serine protease may possibly be involved in the mechanism. The modified beta-VLDL enhanced the accumulation of cholesterol esters by smooth muscle cells (SMC).
Atherosclerosis 1989 Jun
PMID:Macrophages modify beta-VLDL by proteolysis and enhance subsequent lipid accumulation in arterial smooth muscle cells. 275 51

Nutritional and dietary recommendations are given for infants, preschool and school children in Latin America, based on known and prevailing nutritional deficiencies, and on the prevention of degenerative diseases in adulthood. Special emphasis is placed on dietary iron and zinc deficiencies, as well as on the prevention of obesity and atherosclerosis, diseases which are seriously affecting medium and high socioeconomic levels of the Latin American population.
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PMID:[The feeding of children in Latin America]. 285 73

As a contribution to the formulation of food guidelines and nutritional goals for Latin America, this article examines the singular situation of the elderly, defined as those persons over 60 years of age. The projected data for the year 2025, published by the Population Department of the United Nations, show that this age group represents an important sector--6.4% of the population in 1980--that is growing. Some countries, however, do have a rate that is comparable to the United States, 11.3%, such as Argentina, 12.7%, and Uruguay, 14.8%, which is similar to that of Europe. Along with other comparative demographic information, the analysis covers some of the biological, physiological, pathological, and psychosocial characteristics that become more common in senescence. To a certain extent, these characteristics bear a direct or indirect relationship with the energy, protein, and nutrient content of the diet. This becomes more evident upon examining the causes of mortality and morbidity in the elderly, whose diseases are quite often chronic and degenerative. Those with the highest incidence, such as the cardiovascular ones--including cerebrovascular accidents, atherosclerosis, and hypertension--diabetes, obesity, osteoporosis, anemias from lack of iron and folates, and some forms of cancer, reveal the influence of certain nutrients in their pathogenesis. Very few studies have been done on the over-70 age group to determine their requirements for energy, proteins, and various nutrients that serve as the basis for appropriate food guidelines. Usually, estimates are extrapolated from data on the 40-and-over age group. Some maintain that the variations for the elderly are small, but since this group is growing and is far from homogeneous, such a hypothesis must be tested. Following a review of recent literature, the article proposes a set of Food Guidelines and Nutritional Goals for persons over 60 in Latin America. It also recommends to countries interested in formulating their own guidelines how to proceed for the short, medium, and long terms. In Latin America and the Caribbean, the elderly are the most neglected group with reference to government programs, and most forgotten by society. They depend to a great extent on the labor force of each country. They suffer most frequently from chronic diseases and have the most need for medical care, they use a broad range of drugs that may interfere with the absorption and utilization of nutrients, as well as foods when may impair the bioavailability of drugs. They show the highest mortality rates, and, in a high proportion, require a normal diet.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:[Food guidelines and nutritional goals for aging]. 315 33

Atherosclerotic lesions in coronary arteries were compared in 10 hybrid hares and 14 rabbits after induction of hypercholesterolemia, using a cholesterol-enriched diet. All proximal portions of hare coronary arteries contained intimal lesions, often with severe luminal stenosis. These lesions were characterized by the presence of foam cells, smooth muscle cells, and areas of atheronecrosis. Foam cells were also found focally in the media. As part of the intimal changes, iron deposition was present in 65% and calcification was present in 32.5% of proximal segments examined. The proportion of segments with intimal lesions and the intima/media cross-sectional area ratios (I/M ratios) were greatest in proximal segments with stepwise decreases in the mid and distal segments. As area of myocardial infarction was present in one hare. In contrast, 46.5% of proximal segments of rabbit coronary arteries had no intimal lesions and those lesions present had no calcium or iron deposition. No infarction was observed in rabbit hearts. The proportion of segments with lesions and the mean I/M ratios were significantly greater in the hare than the rabbit, with proximal and mid coronary segments showing the most marked differences. The hare appears to develop coronary artery lesions more like those seen in man, with high grade, proximal stenoses occurring uniformly in hypercholesterolemic animals. In contrast, the atherosclerosis developing in rabbit coronary arteries is less uniform and includes involvement of intramyocardial arterioles. The hare offers several advantages as a model of human atherosclerosis.
Atherosclerosis 1987 Feb
PMID:Atherosclerosis in the hypercholesterolemic hare. Comparison of coronary artery lesions induced by dietary cholesterol in the hare and the rabbit. 382 77

A dietary survey was conducted in 1980 in connection with the Multicentre Study on Atherosclerosis Precursors in Finnish Children in five urban and 12 rural communes in various parts of Finland. 1,768 children aged 3, 6, 9, 12, 15 and 18 years were interviewed using the 48 hour recall method. Food consumption, and the intakes of energy and 49 nutrients were calculated. The intakes of energy and most nutrients increased in the successive age groups until the age of 15 years. There were only small differences in the diet of children belonging to different social classes. Protein accounted for 14% of total energy intake, fat for 38%, total carbohydrate for 48%, and sucrose for 10%. The ratio of polyunsaturated and saturated fatty acids in the diet (P/S) was 0.24 for the whole material, which is higher than found in previous studies in Finland. The P/S ratio was higher in urban areas and West Finland than in rural areas and in East Finland. The share of fat of energy intake exceeded the recommendation given by the Ministry of Health and the P/S ratio was lower than recommended. The mean daily intakes of energy and vitamins met the recommendations. Of the mineral elements, the intakes of calcium, phosphorus, potassium, magnesium and manganese were abundant. The intakes of iron, copper, zinc, molybdenum and chromium were lower than recommended in most age groups and the intakes of selenium and fluorine in all age groups. The large share of refined foods in the children's diet was the main reason for the low nutrient densities.
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PMID:Atherosclerosis precursors in Finnish children and adolescents. VIII. Food consumption and nutrient intakes. 386 23

Sephadex particles (20-80 mu in size) were injected into the abdominal aorta of 134 male Sprague-Dawley rats near the renal arteries. In 31 rats, the right kidney was then removed. The Sephadex particles lodged in glomerular capillaries, afferent glomerular arterioles and interlobular arteries, creating renal infarcts, some of which were grossly visible. Shortly after injection, arterial blood pressure rose significantly in most animals. The hypertension in uninephrectomized rats was not demonstrably different from that in rats with two Kidneys. Severity and duration of hypertension (up to 8 months) were positively correlated with the number of Sephadex particles in renal vessels, and there was also a positive correlation between the degree of hypertension and serum urea nitrogen levels, and between degree of hypertension and degree of cardiac hypertrophy. The vascular permeability in acutely hypertensive rats was abnormal, as judged from penetration of iron-dextran into vessel walls. This experimental model resembles atheromatous microembolic renovascular disease, which may play a significant role in the pathogenesis of unexplained hypertension in patients with advanced aortic atherosclerosis.
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PMID:Microembolic renal disease in rats induced with sephadex. 425 58

The effect of Anna Pavala Sindhooram (APS), an indigenous drug showing lipid lowering action was tested in experimental rat atherosclerosis induced by feeding an atherogenic diet. APS was found to decrease the levels of serum cholesterol and phospholipids while triglycerides remained unaffected in atherogenic diet fed rats. Lipid levels in the aorta, liver and intestine were also increased by atherogenic diet feeding, and APS administration with diet restriction reversed this trend. Cholesterol ester was lowered. Both cholesteryl ester hydrolase (CEH) and synthetase (CES) activities in the tissues were elevated while the CEH/CES ratio was lowered in atherosclerosis. APS administration led to a decrease in enzyme activities and an increase in the CEH/CES ratio. APS in vitro inhibited both enzyme activities. NMR spectroscopic studies showed that the soluble components of APS bind or modify cholesterol. Iron, copper, magnesium and calcium present in APS may play a role in the removal of cholesterol ester from the aorta and its disposal.
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PMID:Lipids and cholesterol esterifying enzyme changes by Anna Pavala Sindhooram therapy in experimental rat hyperlipaemia. 663 36

Although there is no evidence for a direct cause-effect relationship between mineral and trace element status and atherosclerosis in humans, many elements exert a strong influence on individual risk factors for cardiovascular disease, such as disorders of blood lipids, blood pressure, coagulation, glucose tolerance, and circulating insulin. Studies in humans and animals have shown that optimal intakes of elements such as sodium, magnesium, calcium, chromium, copper, zinc, and iodine can reduce individual risk factors; some of these studies are consistent with the results of epidemiologic correlations. Influences of local geochemical environment and of dietary practices can result in mineral and trace element imbalances; deficiencies of chromium, iron, copper, zinc, selenium, and iodine are well defined. Detection and correction of such imbalances in populations, through diminishing individual risk factors, might ultimately reduce the incidence of atherosclerotic heart disease.
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PMID:Trace minerals and atherosclerosis. 674 52

The rabbits fed cholesterol show significant changes in lipid metabolism and develop hypercholesterolemia that indicate that development of experimental atherosclerosis in the animals. At the same time there is an increase in the chemiluminescence intensity of apo-B-containing lipoproteins in the presence of divalent iron, reflecting the enhancement of lipid peroxidation in apo-B-containing lipoproteins of rabbit blood serum. The increased chemiluminescence of apo-B-containing lipoproteins within the early stages of experimental atherosclerosis can be used for early diagnosis of atherosclerosis on an experimental and clinical basis.
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PMID:[Chemiluminescence of apo-B-lipoproteins in experimental hypercholesterolemia of rabbits]. 708 88

The oxidation of low-density lipoprotein (LDL) may be important in the pathogenesis of atherosclerosis. However, the interactions between cells and metals in promoting LDL oxidation are inadequately understood. A sensitive high-performance liquid chromatography analysis of cholesterol, cholesteryl esters, and their oxidation products was used to identify and accurately measure LDL oxidation achieved in thiol-free Hanks' balanced salt solution (HBSS) at pH 7.4. Mouse peritoneal macrophages inhibited LDL oxidation when incubated in HBSS containing either 10 microM iron or 1 microM copper, but were markedly prooxidant in the presence of both metals. The prooxidant effect of macrophages in the presence of both iron and copper did not require the provision of added disulfides or thiols. Both Fe2+ and macrophages were demonstrated to independently reduce Cu2+ to Cu1+ in HBSS, indicating that the direct reduction of copper by cells or iron may underlie the observed promotion of LDL oxidation by macrophages in this system. We conclude that macrophages can either promote or inhibit metal-mediated LDL oxidation and that externally supplied thiols are not essential to the promotion of LDL oxidation by cells. The presence of both iron and copper may be particularly important for macrophages to promote LDL oxidation in vivo.
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PMID:Macrophages require both iron and copper to oxidize low-density lipoprotein in Hanks' balanced salt solution. 748 58


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