Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
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Query: UMLS:C0004153 (
atherosclerosis
)
77,401
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Our present knowledge on chemically modified proteins and their receptor systems is originated from a proposal by Goldstein and Brown in 1979 for the receptor for acetylated LDL which is involved in foam cell formation, one of critical steps in atherogenesis. Subsequent extensive studies using oxidized LDL (OxLDL) as a representative ligand disclosed at least 11 different scavenger receptors which are collectively categorized as "scavenger receptor family". Advanced glycation endproducts (AGE) and their receptor systems have been studied independently until recent findings that AGE-proteins are also recognized as active ligands by scavenger receptors including class A scavenger receptor (SR-A), class B scavenger receptors such as CD36 and SR-BI, type D scavenger receptor (LOX-1) and
FEEL-1
/FEEL-2. Three messages can be summarized from these experiments; (i) endocytic uptake of OxLDL and AGE-proteins by macrophages or macrophage-derived cells is mainly mediated by SR-A and CD36, which is an important step for foam cell formation in the early stage of
atherosclerosis
, (ii) selective uptake of cholesteryl esters of high density lipoprotein (HDL) mediated by SR-BI is inhibited by AGE-proteins, suggesting a potential pathological role of AGE in a HDL-mediated reverse cholesterol transport system, (iii) a novel scavenger receptor is involved in hepatic clearance of plasma OxLDL and AGE-proteins.
...
PMID:Scavenger receptors for oxidized and glycated proteins. 1466 Oct 91
The scavenger receptor
FEEL-1
/stabilin-1 is known as the marker of alternatively activated macrophage and sinusoidal endothelial cell.
FEEL-1
/stabilin-1 is a multifunctional transmembrane glycoprotein that is implicated in bacterial infection, diabetes,
atherosclerosis
, wound healing, and innate immunity. In the current study, we have identified the phox-homology domain containing protein SNX17 as a novel interaction partner of
FEEL-1
/stabilin-1 in endothelial cells. SNX17 directly interacts with
FEEL-1
/stabilin-1 and regulates its trafficking. Studies using the cytoplasmic domain of truncated or mutant
FEEL-1
/stabilin-1 suggest that the NPxF motif of the
FEEL-1
/stabilin-1 cytoplasmic tail is required for its interaction with SNX17. By transfecting cells with small interfering RNA targeting SNX17, total cellular
FEEL-1
/stabilin-1 expression and
FEEL-1
/stabilin-1-mediated ligand uptake were significantly decreased due to the enhancement of
FEEL-1
/stabilin-1 protein degradation. Our results identify SNX17 as a novel interaction partner of
FEEL-1
/stabilin-1 in endothelial cells.
...
PMID:Adaptor protein sorting nexin 17 interacts with the scavenger receptor FEEL-1/stabilin-1 and modulates its expression on the cell surface. 2022 21
