Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0004153 (
atherosclerosis
)
77,401
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In past decades, growing evidence from basic and clinical researches reveal that small guanosine triphosphate binding protein
ras homolog gene family, member A
(
RhoA
) and its main effector Rho-associated kinase (ROCK) play central and complex roles in cardiovascular systems, and increasing
RhoA
and ROCK activity is associated with a broad range of cardiovascular diseases such as congestive heart failure,
atherosclerosis
, and hypertension. Favorable outcomes have been observed with ROCK inhibitors treatment. In this review, we briefly summarize the pathophysiological roles of
RhoA
/ROCK signaling pathway on cardiovascular system, displaying the potential benefits in the cardiovascular system with controlling
RhoA
/ROCK signaling pathway.
...
PMID:Pathophysiological effects of RhoA and Rho-associated kinase on cardiovascular system. 2655 65
