Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0004153 (
atherosclerosis
)
77,401
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The changes in the activity of intracellular proteolytic systems are important mechanisms in the damage of blood vessels walls and arterial hypertension. Tripeptidyl peptidase II (
TPP
II) is one of the giant intracellular protease that is still poorly known. It fulfils hydrolysis of peptides, coming from proteasomal proteolysis. Modeling of cholesterol
atherosclerosis
in rabbits (1% of cholesterol in diet for 2 month) results in the significant decrease of
TPP
II activity in aorta tissues. This diet in spontaneously hypertensive rats (SHR) leads to a decrease of
TPP
II activity in aorta tissues (on 50%, P < 0.05) but has no influence on the activity of
TPP
II in Wistar rats. Application of Quercetin prevents the inhibition of
TPP
II activity in aorta tissues of rabbits and SHR at experimental hypercholesterolemia. The data received show that changes in the activity of
TPP
II play an important role in pathogenesis of blood vessels wall in
atherosclerosis
and arterial hypertension.
...
PMID:[The changes in the activity of tripeptidyl peptidase II in experimental atherosclerosis and hypertension]. 2509 68
Inflammation is a protective response to stimuli trauma, which can also lead to severe tissue injury. The existing anti-inflammatory drugs, such as corticosteroids and glucocorticoids, generally exhibit side effects and poor accumulation in inflammatory tissue. Hence, a theranostic nanoplatform with serial reactive oxygen species (ROS) responsiveness and two-photon AIE bioimaging has been constructed for dimensional diagnosis and accurate therapy of inflammation. Prednisolone (Pred) is bridged to a two-photon fluorophore (
TP
) developed by us via a ROS sensitive bond to form a diagnosis-therapy compound
TPP
, which is then loaded by the amphipathic polymer PMPC-PMEMA (PMM) through self-assembling into the core-shell structured micelles (TPP@PMM). With a particle size of 57.5 nm, TPP@PMM can realize the accumulation in the inflammatory site via the oedematous tissue and the accurate release of anti-inflammatory drug Pred through the serial response to the local overexpressed ROS. The micellar structure is first interrupted by the ROS triggered hydrophobic-to-hydrophilic conversion of PMEMA, which allows the release of
TPP
. Then the ROS responsive bond in
TPP
is subsequently broken, resulting in the accurate delivery of Pred and the inflammation therapy. Furthermore, TPP@PMM can be traced
in vivo
with a distinct two-photon imaging due to the AIE active fluorophore
TP
. The theranostic TPP@PMM reveals high-resolution inflammation diagnosis and efficient anti-inflammatory activity owing to the two-photon fluorophore and the serial ROS responsiveness and has been proven to achieve the efficient treatment of acute lung injury, arthritis, and
atherosclerosis
. Therefore, TPP@PMM holds considerable promise as a potential strategy for acute and chronic inflammation theranostics.
...
PMID:Reactive Oxygen Species Responsive Theranostic Nanoplatform for Two-Photon Aggregation-Induced Emission Imaging and Therapy of Acute and Chronic Inflammation. 3237 16
P-selectin overexpressed on activated endothelial cells and platelets is a new target for treatment of cancers and cardiovascular diseases such as
atherosclerosis
and thrombosis. In this study, depolymerized low molecular weight fucoidan (LMWF
8775
) and a thermolysin-hydrolyzed protamine peptide (
TPP
1880
) were prepared.
TPP
1880
and LMWF
8775
were able to form self-assembled complex nanoparticles (CNPs). The formation of
TPP
1880
/LMWF
8775
CNPs was characterized by Fourier-transform infrared spectra, circular dichroism spectra and isothermal titration calorimetry. The CNPs selectively targeted PMA-stimulated, inflamed endothelial cells (HUVECs) with high expression of P-selectin. Gd-DTPA MRI contrast agent was successfully loaded in the CNPs with better T
1
relaxivity and selectively accumulated in the activated HUVECs with increased MRI intensity and reduced cytotoxicity as compared to free Gd-DTPA. Our results suggest that the
TPP
1880
/LMWF
8775
CNPs may have potential in future for early diagnosis of cardiovascular diseases and cancers in which the endothelium is inflamed or activated.
...
PMID:Synthesis and characterization of Gd-DTPA/fucoidan/peptide complex nanoparticle and in vitro magnetic resonance imaging of inflamed endothelial cells. 3299 13
