Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0004153 (
atherosclerosis
)
77,401
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Benzoporphyrin derivative
(
BPD
) has been demonstrated to be a new potent photosensitizer for photodynamic therapy (PDT). Although most of the work on
BPD
has been focused on its potential applications for cancer treatment,
BPD
may have potential clinical uses in the treatment of
atherosclerosis
. The purpose of this study was to determine in vitro and in vivo uptake of
BPD
into atherosclerotic plaque. Samples of atherosclerotic human femoral and popliteal arteries were incubated with
BPD
-monoacid, ring A (BPD-MA) for 1 h in the following concentrations: 1, 5, 10, 20, 30 and 40 micrograms/mL. Fluorescence from all samples was determined by chemical extraction with a spectrofluorometer. The tissue concentration for human arteries was 0.37 +/- 0.03, 2.78 +/- 1.5, 3.6 +/- 1.91, 7.15 +/- 2.36, 8.06 +/- 3.09 and 14.6 +/- 4.81 micrograms/g, respectively. In addition, three miniswine were rendered atherosclerotic and given
BPD
2.0 mg/kg intravenously. The concentration of
BPD
-MA in miniswine aorta was 93-190 ng/g and the plaque/normal ratio was 1.7-3.5. For miniswine iliac arteries, the [
BPD
-MA] was 60-178 ng/g and the plaque/normal ratio was 1.1-3.3. Normal miniswine carotid artery contained 54 ng/g. This study showed that
BPD
-MA was taken up in atherosclerotic vessels both in vitro and in vivo and may have potential for PDT of
atherosclerosis
.
...
PMID:In vitro and in vivo uptake of benzoporphyrin derivative into human and miniswine atherosclerotic plaque. 850 97
