Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The dipyridamole test was performed during diagnostic coronaro-ventriculography in 7 patients showing no angiographic signs of coronary atherosclerosis (group 1) and 15 patients with a 75% stenosis in one or more coronary arteries (group 2). The test provoked an anginal attack in 11 (73%) second-group patients that was accompanied with the emergence or aggravation of asynergy in 10 (67%) or ischemic electrocardiographic changes in 7 (47%). In all cases, the anginal attack was associated with a rise in end diastolic pressure. All first-group patients showed no response to the dipyridamole test as evidenced clinically and electrocardiographically. No asynergic zones were identified on any of the ventriculograms recorded after dipyridamole administration.
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PMID:[Changes in segmental and general left ventricular myocardial contractility and intracardiac hemodynamics in the dipyridamole test of patients with ischemic heart disease (data of roentgenocontrast ventriculography)]. 379 8

Myocardial contractility was studied in 44 patients with ischaemic heart disease (28 with asynergy) without congestive circulatory insufficiency depending on the degree of coronary atherosclerosis and regional disorder in the movement of the wall of the left ventricle by ventriculography and tensiometry (dp/dt max, Veraguth index, VCE40; t-dp/dt max). No dependence was detected between the growth of the total lesions of cardiac arteries and the increase of the end diastolic and end systolic volumes and the fall of the ejection fraction in patients with normokinesia of the left ventricle. However, a strong inverse relationship has been established between the number of the affected segments of the heart and the ejection fraction (r = -0.90). It was shown that indices of contractility reflecting the pre-ejection phase (dp/dt max, Veraguth index VCE40; t-dp/ max) are less sensitive in determining the cardiac insufficiency than Vcf and must be interpreted simultaneously with the results of the regional contractility according to the ventriculography data.
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PMID:[Myocardial contractile capacity in ischemic heart disease depending on the degree of coronary arteriosclerosis and the presence of parietal asynergy of the left ventricle]. 710 48