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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty obese subjects (Males = 8, Females = 12; average age = 39.5 +/- 2.5 years; B.M.I. = 36.2 +/- 2.5), 20 overweight subjects (Males = 8, Females = 12; average age = 38.5 +/- 2 years; B.M.I. = 28.8 +/- 0.4) and 20 non obese healthy subjects as controls, matched for sex and age (Males = 8, Females = 12; average age = 37.5 +/- 2 years; B.M.I. = 22.4 +/- 0.8) were selected. We determined: blood glucose, triglycerides, total cholesterol, HDL-cholesterol, Apolipoproteins A1 and B, Factor VII, fibrinogen and plasminogen. Before and after a venous occlusion test were also measured: t-PA Antigen, PAI activity and haematocrit. Metabolic, coagulative and fibrinolytic pathological changes were observed in overweight and obese subjects and the interaction of these risk factors may contribute to the pathogenesis of atherosclerosis vascular disease and to the high rate of thromboembolic events reported in obesity.
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PMID:Evaluation of cardiovascular risk factors in overweight and obese subjects. 807 94

Epidemiological work on the age-dependency of the relation between overweight and mortality confirms an opinion which is traditional among physicians and has it roots in a mixture of biological understanding and common sense. The data base can be summarized in three points: 1) Up to the age of 60-65 years, overweight is combined with decreased life expectancy. The excess mortality is found mainly in the cardiovascular area and can be explained by the well-known risk factors of atherosclerosis. In the Framingham-study, overweight per se is a risk factor for this group of diagnoses. 2) In the age group 65-74 years, the relation between overweight and excess mortality vanishes gradually; the right arm of the U- or J-curve levels off. The optimal BMI moves to the right, and the right arm of the curve is shortened. 3) In high age, from 75-80 years on, overweight coincides with improved prognosis. The geriatric literature is in agreement in the sense that overweight is no problem in high age.
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PMID:[Obesity in the elderly and very elderly--prognostic significance and practical conclusions]. 809 41

The data of the first 100 patients undergoing heart transplantation in the period between January 1984 and May 1993 were analyzed. Of this group, 57 patients are alive. Out of the total of 43 deaths, 14 patients died from graft failure within the first postoperative days, 6 died from surgical complications, 11 from infection, 10 deaths were due to accelerated coronary atherosclerosis, and 2 patients died from tumours. Early mortality rates (within 30 days since surgery) were 37% and 17% in patients operated on between 1984-88 and between 1989-93, respectively. The health condition of heart transplant recipients is affected by side effects of immunosuppressive therapy. Forty per cent of patients re-develop systemic hypertension within the first post-transplantation year. Five years after transplantation, hypertension is detected in 60% of patients. Elevated serum creatinine levels are present in 70% of patients by the end of the first post-transplantation year. In the ensuing period, there is no progression in renal function impairment, which does not require cyclosporin withdrawal and is not associated with the development of hypertension. In the first post-transplantation year, 45% of patients are markedly obese. All patients with overweight and obesity show markedly raised levels of serum cholesterol. Another undesirable effect (mainly due to corticosteroid therapy) is the development of ulcers in 16% of patients. Heart transplantation has become an established method at the Institute for Clinical and Experimental Medicine in Prague. Despite the above pitfalls, heart transplantation substantially prolongs the life of patients and dramatically alters the quality of their life.
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PMID:[The patient after heart transplantation]. 814 61

Lipoprotein(a)[Lp(a)] concentrations and their correlation to total cholesterol (TC), low-density and high-density lipoprotein cholesterol (LDL-C, HDL-C) and triglycerides (TG) were estimated in 20 normal weight children affected with familial hypercholesterolemia (FH) and for comparison in 20 overweight, but otherwise healthy children, matched for sex and age. The mean value of Lp(a) in patients with FH (0.29 g/l, SD = 0.27) was markedly higher than in the control group (0.17g/l, SD = 0.19), but the difference was not statistically significant. However, the frequency distribution of Lp(a) in both groups was different: the proportion of Lp(a) levels above 0.60g/l was significantly greater in patients with FH than in the controls (p < 0.05). These results indicate that even pediatric patients with FH have increased Lp(a) levels. Since Lp(a) elevation above 0.25 to 0.30g/l--in particular in combination with increased LDL concentrations--is is associated with a markedly increased risk of coronary heart disease, cervical atherosclerosis and cerebral infarction, it seems very important to detect these high-risk individuals as early as possible and to treat them appropriately.
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PMID:Elevated levels of lipoprotein (a) in children with familial hypercholesterolemia. 819 53

In families of subjects with premature ischaemic cerebrovascular attacks (a total of 45 families with 190 members) the authors detected a high incidence of dyslipidaemia, arterial hypertension, impaired glucose tolerance and non-insulin dependent diabetes mellitus, frequently with striking cumulation. The authors investigated therefore the relationship of the insulin level as an indirect reflection of insulin resistance with these risk factors. The fasting insulin levels correlated significantly positively with triglyceride levels, apolipoprotein B, atherogenic indices and negatively with HDL-cholesterol. The probands and siblings with arterial hypertension had significantly higher fasting insulin levels, as compared with subjects without hypertension which was due to a more frequent incidence of overweight. Patients with an impaired glucose tolerance and NIDDM had significantly higher fasting insulin levels and insulin levels after two hours (the latter value was not assessed in diabetes) and unfavourable "atherogenic" lipid and lipoprotein values, as compared with subjects without glucose intolerance and the control group. Overweight (BMI > 26) had an adverse impact on all investigated indicators of lipid and carbohydrate metabolism whereby a W/H ratio > 0.85 as a manifestation of central obesity further accentuated this adverse effect. The authors draw from these results therapeutic conclusions as regards the mentioned risk factors in these families. They emphasize the importance of non-pharmacological intervention of the metabolic X syndrome by weight reduction and more physical activity not only in families of subjects with early atherosclerosis but in the entire population which has a high prevalence of cardiovascular diseases.
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PMID:[Reaven's metabolic syndrome X in the families of individuals with premature cerebrovascular attacks]. 821 22

During the first year the Austrian Stroke Prevention Study enrolled 599 volunteers without clinical signs or symptoms of cerebrovascular disease aged 50 to 70 years. Study participants were randomly selected from the official register of the city of Graz. The rate of positive response was 26.9 percent. All subjects underwent an extensive risk factor screening with Duplex scanning of the carotid arteries obtained from a subset of 176 individuals. The prevalence of well-documented cerebrovascular risk factors was 40.6% for arterial hypertension, 35.4% for cardiac disease, 8.5% for diabetes mellitus und 3% for elevated haematocrit. The less well-documented cerebrovascular risk factors dyslipidemia, overweight, physical inactivity, hyperfibrinogenemia and smoking were noted in 75%, 33.7%, 27.2%, 14.9% and 12.2% of subjects, respectively. Multiple well-documented risk factors were noted in 23.7% of the examined volunteers. Multiple linear regression analysis revealed body mass index (p < 0.0001) and age (p < 0.0001) as independent predictors of the frequency of well-documented risk factors observed in any individual. Atherosclerotic carotid disease occurred in 61.9% of study participants investigated by Doppler sonography and was significantly associated with age (p < 0.00001), life-time tobacco consumption (p < 0.0001) and the concentration of apolipoprotein B (p < 0.05). This study demonstrates high prevalence rates of vascular risk factors in an elderly Austrian community. Implications for stroke prevention result from the conjunction of overweight and frequency of risk factors noted in any study participant, as well as from the relationship of carotid atherosclerosis to smoking and dyslipidemia.
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PMID:Cerebrovascular risk factors in an elderly Austrian population: first year results of the Austrian Stroke Prevention Study (ASPS). 836 75

Dietary treatments for hyperlipidemia, hypertension, diabetes mellitus and obesity are essential for the prevention or management of atherosclerosis. To correct overweight or obesity, restriction of energy intake should be considered. The consumption of fat should be decreased less than 25 percent of total energy. The ratio of saturated fatty acid, monounsaturaled fatty acid and polyunsaturated fatty acid is recommended as 1:1:1. Intake of oily fish should be included in daily meal. The ratio of n-6/n-3 polyunsaturated fatty acid is considered to be beneficial around three or four. Excess intake of simple sugars must be avoided and increase the intake of complex carbohydrate and dietary fibre are recommended.
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PMID:[Dietary treatment of atherosclerosis]. 841 76

The action of female sex steroids on carbohydrate metabolism has clearly been demonstrated by numerous clinical and experimental studies. A beneficial effect of 17 beta oestradiol has been reported on insulin secretion and insulin sensitivity, inducing an improvement of glucose tolerance through an increase of glucose clearance by liver, muscle and adipose tissues. Progesterone has, to a lesser degree, the same stimulant effect on insulin secretion and improves glucose assimilation by the liver, although a relative insulin resistance is observed in the other two tissues. Menopausal hormonal privation does not significantly alter glucose tolerance in the absence of such predisposition factors as overweight or history of gestational or familial diabetes mellitus. The first trials of menopausal substitution with oral synthetic oestrogens, especially in doses of more than 50 micrograms per day, were responsible for the bad reputation of oestroprogestins due to their effects on metabolic parameters. As shown by prescription for contraceptive use, replacement therapy with oral synthetic oestrogens induces a diabetogenic tendency as well as hypertensive, dyslipidaemic and thrombogenic risks, especially when associated with progestins issued from nortestosterone. Reducing the oestrogen doses, using equine sulfoconjugates and selecting non-androgenic progestins has already minimized these deleterious effects. The present availability of oral or percutaneous natural 17 beta oestradiol and of norpregnanes calls for reconsideration of the glucidic risk due to oestroprogestin prescription. A few studies have already shown that in fact they can improve glucose tolerance. The recommended substitution of menopause to prevent atherosclerosis must lead to a better characterization of its glycaemic and insulinaemic effects.
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PMID:[Sex steroids. Effects on the carbohydrate metabolism before and after menopause]. 850 47

The moderation control of blood pressure is one key strategy to control the progression of coronary artery disease. In the pathogenesis of coronary artery disease, hypertension should not be viewed on its own; however, other risk factors, which may influence hypertension and atherogenesis at the same time, should be evaluated carefully. In primary and also secondary prevention of coronary artery disease, overweight and obesity play an important modulating role. Especially the abdominal (visceral) form of obesity should be controlled. The reduction of dietary fat intake seems to be the major strategy to control body fat accumulation and weight gain, since the intake of excess fat does not lead to an increased oxidation of fat. The reduction of fat intake is also the major nonpharmacological strategy to promote regression of atherosclerosis and to control body weight.
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PMID:[Hypertension and coronary heart disease. Global risk moderation through control of body weight]. 864 4

Stroke (cerebrovascular accident, CVA) is the third leading cause of death and an important cause of hospital admission and long-term disability in England and Wales. Atherosclerotic lesions at the bifurcation of the common carotid artery are the most common cause of stroke. On occasion, these lesions are partially calcified and visible on a conventional panoramic dental radiograph. The atheroma may appear either as a nodular radiopaque mass or as two radiopaque vertical lines within the soft tissues of the neck at the level of the lower margin of the third cervical vertebra (C3). These opacities are separate and distinct from the hyoid bone and variably appear above or below it. Dentists should scrupulously review the panoramic radiographs of all individuals over the age 55 with medical histories (hypertension, diabetes mellitus, hypercholesterolaemia, coronary artery disease) and behaviours (smoking, alcohol abuse, dietary indiscretion, overweight, sedentary life-style) known to be associated with atherosclerosis and stroke.
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PMID:Panoramic dental radiography: an aid in detecting individuals prone to stroke. 875 17


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