Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Aneurysm formation and rupture within the petrous internal carotid artery (ICA) is an extremely rare occurrence with approximately 10 such cases in the literature. Etiologies of petrous ICA aneurysms include atherosclerosis, closed head trauma, iatrogenic injury during mastoid surgery, chronic middle ear infections, and congenital causes. Therapeutic options include carotid artery ligation, aneurysm resection with or without reconstruction, and radiographically controlled vessel occlusion. The case of a patient who presented with otorrhagia, epistaxis, and transient focal neurologic signs due to a ruptured petrous ICA aneurysm is presented. The incidence, etiology, and anatomy of these aneurysms is reviewed, and the various tests for determining adequacy of collateral cerebral blood flow are described. Factors that affect the selection of surgical versus radiologic control of these lesions are also discussed.
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PMID:Ruptured petrous carotid aneurysm presenting with otorrhagia and epistaxis. 178 9

Extracranial internal carotid artery aneurysms are uncommon. The symptoms of these aneurysms vary according to their location and size. Larger aneurysms may present as cervical or parapharyngeal masses, which may or may not be pulsatile or tender; there may be an associated systolic bruit. Pharyngeal hemorrhage, epistaxis, or bleeding from the ear are rare manifestations. Ischemic symptoms are a frequent mode of presentation of these aneurysms. Arterial diseases, particularly atherosclerosis, may predispose the vessel to the formation of the aneurysm. Sometimes trauma is the cause. We report herein six cases of extracranial internal carotid artery aneurysms. The modes of presentation, the etiologic factors, the pathologic observations, and the methods of management are discussed, and the pertinent literature is reviewed.
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PMID:Extracranial internal carotid artery aneurysms. 704 7