Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sudden, transient loss of vision in one eye (amaurosis fugax) is associated frequently with atherosclerosis of the internal carotid artery in adults and may herald a stroke. Thus, cerebral angiography is often performed. Amaurosis fugax in children is uncommon and an underlying cause is rarely demonstrated. Recurrent episodes of amaurosis fugax occurred in five adolescents. A characteristic evolution and pattern of visual loss, consistent with choroidal ischemia as the underlying mechanism, was described by four of them. Although none of the episodes were accompanied by headache, four patients had a history of common migraine at other times or a family history of migraine. These episodes of visual loss may represent a migraine variant, and cerebral angiography is not indicated in adolescents with such a history.
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PMID:Amaurosis fugax in teenagers. A migraine variant. 334 21

Amaurosis fugax is a term used to describe transient monocular visual loss due to atherosclerosis of the ipsilateral internal carotid artery. It is differentiated from other causes of transient monocular blindness, especially retinal migraine. It is said that amaurosis fugax episodes are short in duration and only occasionally include "positive" visual phenomena such as scintillations. Monocular migraine is more prolonged and often accompanied by scintillations. We studied 37 patients with amaurosis fugax and angiographic evidence of carotid atherosclerosis ipsilateral to the symptomatic eye. Nearly one-third of the patients had long attacks or positive visual phenomena. In many patients, transient monocular visual loss due to carotid atherosclerosis cannot be differentiated from retinal migraine based on clinical symptoms alone.
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PMID:Symptoms of amaurosis fugax in atherosclerotic carotid artery disease. 357 86

Carotid artery disease is often implicated in primary ischemic stroke secondary to thrombosis or embolism and may indicate concurrent cardiovascular disease. Atherosclerosis is the underlying cause of the majority of strokes. It is highly correlated with carotid artery disease because it occurs most often at the bifurcation of the common carotids. Transient ischemic attacks are an important clinical syndrome in the diagnostic evaluation of patients with carotid insufficiency. Amaurosis fugax is typically the most common ocular symptom. In addition to a careful history and physical examination, definitive diagnosis and appropriate management of carotid disease mandates defining the location and extent of stenosis. Noninvasive duplex scanning is an ideal technique for determining which patients should proceed with invasive arteriography and carotid endarterectomy. Clinical trials have now officially established the value of endarterectomy in patients with carotid artery disease.
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PMID:Carotid artery disease. 791 91