Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We evaluated the ability of Lensmeter 701 (LOM) to detect changes in the transparency of the lens graded with the Lens Opacities Classification System II (LOCS II). In this prospective study 410 middle-aged Eastern Finnish men participating in the Kuopio Atherosclerosis Prevention Study were examined three times at eighteen month intervals, and lens opacities were graded with both LOM and LOCS II, the latter serving as the standard. Majority of the change in the LOM reading during the follow-up fell within the 95% tolerance interval of the apparatus (3.08 units). Only four eyes showing progression by LOCS II were detected by LOM. The association between LOM change and the change observed by LOCS II was not statistically significant, and the correspondence of the two methods was weak. It seems that the sensitivity of the LOM is not sufficient to detect small changes in the transparency of the lens over time.
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PMID:Lens opacity increase in a longitudinal study: comparison of the lens opacities classification system II and lensmeter 701. 865 9

The purpose of the present study was to evaluate the change in visual acuity and refraction taking place in eyes with progressing early lens opacities. Four hundred and ten hypercholesterolemic men in Eastern Finland who participated in the Kuopio Atherosclerosis Prevention Study were followed up for 3 years. Lens opacities were graded using the lens opacity classification system II (LOCS II). The change of visual acuity and refractive error from baseline to a 36-month examination was compared for different types of lens opacities. During the 3-year period, progression in the LOCS II was observed in 9.2% of the eyes for nuclear, in 4.8% for cortical and in 0.5% of the eyes for posterior subcapsular opacities. Increasing nuclear sclerosis reduced visual acuity statistically significantly both with and without correction. Hypermetropization was seen to continue in eyes with no lens opacity progression. Myopization was more common in eyes with lens opacity progression, although this was not statistically significant.
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PMID:The impact of early lens opacity progression on visual acuity and refraction. 921 16