Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of the beta-blocker propranolol and of bensonal, a barbituric acid derivative stimulating microsomal oxidation of the liver monooxygenase, was evaluated using the model of experimental myocardial infarction (EMI) in the presence of 3-month cholesterol atherosclerosis. Using light and electron microscopy, polarography and weight planimetry atherosclerosis was shown to complicate considerably the course of EMI analyzed 1, 3, 7, 15 and 30 days after the coronary artery ligation. The drugs given at the same intervals improved the structure and metabolism of different myocardial zones while limiting necrotic areas for 7 days of EMI.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1985
PMID:[Experimental myocardial infarction in atherosclerosis--various methods of pharmacological correction]. 400 54

Development of atherosclerotic lesions in the human aortic intima has been studied using morphological and biochemical methods. It is shown that the sublayers of the human aortic intima are involved in the atherosclerotic processes in different degree. Such manifestation of atherosclerosis as lipid and collagen take up and intimal thickness are especially connected with juxtluminal layer of the intima. Stellate cells (one of the 4 morphological types in the intima) are most closely correlated with these processes. The problems of the origin and possible role of the intima cells in the atherosclerosis are discussed.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1985
PMID:[Cellular composition and biochemical characteristics of the human aorta]. 406 84

Comparisons were made between the clinical picture, results of bicycle ergometry and selective coronaroangiography, and the data of transesophageal electrical stimulation of the left atrium in 52 patients, including 31 with stenosing coronary atherosclerosis. The feasibility of applying the transesophageal stimulation for the diagnosis of coronary heart disease is shown. The sensitivity of transesophageal electrical stimulation of the left atrium in detecting stenosing coronary atherosclerosis was 81%, its specificity being 79%.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1984
PMID:[Comparative evaluation of the importance of transesophageal electrical stimulation of the left atrium and bicycle ergometry in diagnosing ischemic heart disease]. 650 21

Malonic dialdehyde (MDA) content was studied in 23 patients with CHD due to coronary atherosclerosis, and in 6 with neurocirculatory dystonia without clinical and angiographic signs of CHD. MDA content as an indirect equivalent of cyclic endoperoxides was higher in the platelets, LDL and VLDL in patients with CHD. It may be a cause of TxA2 and PGI2 unbalance in the blood circulation and leads to the activation of thrombus formation, the decrease in the synthesis of "antiatherogenic" biologically active substances, in particular PGI2, thus promoting the development of CHD due to coronary atherosclerosis.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1984
PMID:[Malondialdehyde content of plasma lipoproteins and thrombocytes in patients with ischemic heart disease]. 650 34

Myocardial microcirculatory bed was studied using ultrastructural analysis in 28 males, aged 30 to 55, who suffered from coronary atherosclerosis and died suddenly. The authors found a lowered capillaries/myocytes ratio. A part of myocardial capillaries were excluded from hemocirculation due to obturation of their lumen with endothelial microvilli and blood cells. Open capillaries showed signs of activation of adaptational mechanisms of compensation of myocardial microvascular bed insufficiency.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1981
PMID:[Ultrastructural characteristics of the myocardial microcirculatory bed in coronary arteriosclerosis]. 725 63

The article deals with the results of a prospective (3.8 year long) study of a nonorganized male population (40-59 years of age) in one of Moscow districts. Total blood plasma cholesterol, triglycerides, and HDL cholesterol were determined in 3663 men. The results of the study show that to assess the risk of death from atherosclerosis, coefficient of total cholesterol fractions ratio should be taken into account.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1981
PMID:[Mortality in men 40 to 59 years old from coronary and cerebral arteriosclerosis with varying cholesterol and triglyceride levels in the blood]. 725 71

Diagnosis depends on the clinical manifestations, blood or cerebrospinal fluid study and MRI findings. Acute and subacute intraparenchymal spinal cord disorders are due to vascular disorders or myelitis. Spinal cord infarction is associated with dissecting aortic aneurysm, surgical clipping of aortic aneurysms, aortic atherosclerosis or hypotension from any cause. Hematomyelia results from trauma, vascular malformations, vasculitis, or a coagulation disorder. Acute infectious myelopathies result from direct invasion of the spinal cord by bacteria, parasite, or virus. The cause of acute or subacute inflammatory disease include multiple sclerosis, Devic disease, acute disseminated encephalomyelitis, SLE, or sarciodosis. Sarcoidosis sometimes requires differential diagnosis with cord tumor. Chronic intraparenchymal spinal cord disorders are due to syringomyelia, familial spastic paraplegia, HTLV-1 associated myelopathy, adrenomyeloneuropathy, and vascular malformations. HTLV-1 associated myelopathy present with progressive spastic paraplegia with bladder disturbance and has antibodies to HTLV-1 in the cerebrospinal fluid and serum. Diagnosis of adrenomyeloneuropathy is made by demonstration of elevated levels of very long chain fatty acids in plasma. Vascular malformations are important lesions because they present a treatable cause of progressive myelopathy.
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PMID:[Medical approach to intraparenchymal spinal cord disorders]. 1278 77

Hexacosanoic acid (C26:0) (1), a very long-chain fatty acid, is related to various diseases such as adrenoleukodystrophy (ALD), adrenomyeloneuropathy (AMN) and atherosclerosis. As the level of 1 higher than the normal is related to diseases above, hexacosanoic acid (1) and the ceramide 2, which contains 1, are thought to play an important role in various tissues. Hexacosanoic acid (1) is known to be a waxy solid and to be hard to dissolve in water as well as organic solvents. Due to this physical property, it is not easy to handle hexacosanoic acid (1) in a laboratory. Therefore, efficient chemical synthesis of the compounds 1 and 2 has not been reported. Here, we report a versatile synthetic method for hexacosanoic acid (1) and the ceramide 2 containing the fatty acid 1. Synthesis of hexacosanoic acid (1) was achieved by applying the coupling of two alkyl units as a key step. Ceramide 2 was efficiently synthesized by applying the reported procedure together with hexacosanoic acid (1) synthesized here. This synthetic strategy has an advantage of getting various carbon chain length fatty acids and their ceramides by using a variety of carbon chain units. This method is also applicable for large-scale synthesis. In addition, these compounds 1 and 2 are useful for investigation of details of these compounds related to diseases such as ALD and AMN.
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PMID:Chemical Synthesis of a Very Long-Chain Fatty Acid, Hexacosanoic Acid (C26:0), and the Ceramide Containing Hexacosanoic Acid. 2622 58


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