Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Labelled microspheres in combination with reactive myocardial hyperemia were used to assess the state of the expansion reserves of the myocardial microcirculation in patients with coronary heart disease (CHD). It was found that in the majority of CHD patients the expansion reserves were reduced whereas in patients with marked atherosclerosis of the coronary arteries and post-infarction cardiosclerosis they were absent altogether.
 ...
PMID:[Dilatation reserves of the myocardial microcirculation in ischemic heart disease patients based on scanning data using labelled microspheres]. 674 89

Total cholesterol and triglycerides as well as their distribution among the different hyperlipoproteinemia types were studied in three patients groups: 47 normotensive patients with myocardial infarction, 35 normotensive patients with cardiosclerosis (chronic ischemic heart disease), 29 hypertensive patients without symptoms or signs of clinical atherosclerosis. Their results were compared to those of 45 normal controls. There was no decrease in HDL cholesterol nor increase in LDL cholesterol in patients with chronic or acute ischemic heart disease. A large percentage of patients from these groups had normolipoproteinemia. The most prominent lipidic changes were observed in hypertensive patients: no patient had a HDL cholesterol level above normal values, thirty three per cent had a HDL cholesterol level below 35 mg/dl. A high percentage of patients with acute myocardial infarction or hypertension exhibited atypical lipoproteinemia anomalies (hyper HDL triglyceridemia, hyper LDL triglyceridemia, hyper VLDL cholesterolemia) when they could have normolipoproteinemia. This suggested lipoproteinic metabolism disturbances in such cases.
 ...
PMID:[Changes in serum lipid levels, lipid composition and lipoprotein fractions in patients with ischemic cardiopathies or arterial hypertension]. 733 37

Hearts of 38 men dying suddenly of acute coronary insufficiency and autopsied within 3 hours after death were examined. Foci of acute ischemic injuries in different parts of the myocardium were studied by histochemical methods for which the activity of succinate dehydrogenase and phosphorylase were determined. Early ischemic lesions in the myocardium were found in 22 fatalities, of them 5 had acute myocardial infarction, in 9 foci of ischemia were combined with the presence of postinfarction scars and fine focal cardiosclerosis, in 8 cases foci of early ischemia were the only changes in the myocardium. The majority of the decreased had stenosing atherosclerosis of the coronary arteries. Localization of ischemia foci in the myocardium did not always correspond to the severity of stenosing or the presence of thrombosis of the artery supplying the corresponding parts of the heart muscle. No foci of ischemia in the myocardium were found in 16 decreased who also had quite marked coronary atherosclerosis.
 ...
PMID:[Early ischemic injuries of the myocardium in sudden cardiac death]. 742 69

While studying the functional activity of poly- and mononuclear leucocytes in 75 patients with various clinical types of ischemic heart disease (angina of effort, angina decubitus, arrhythmias, cardiac insufficiency at the background of atherosclerotic cardiosclerosis and atherosclerotic hypertension), decline in the functional activity of the phagocytizing cells has been revealed, this being considered to be a pathogenetic prerequisite for atherosclerosis progression.
 ...
PMID:[The functional activity of the poly- and mononuclear leukocytes in patients with different clinical forms of ischemic heart disease]. 783 69

Visualization of the myocardium with the use of various high technologies gains more and more important significance in diseases of cardiovascular system. Large value for investigations of the heart and blood vessels have acquired methods of echocardiography, magnetic resonance tomography, spiral computed tomography, as well as large spectrum of methods of nuclear cardiology. Contemporary value of instrumental methods of investigation for diagnostics of atherosclerosis is discussed in this paper and diagnostic possibilities of various techniques for assessment of the state of myocardium, pathological changes of vascular wall and for visualization of atherosclerotic plaques (AP) are presented. Advantages and drawbacks of methods, their complex application for objective analysis of changes in AP and their clinical significance are considered. Special accent is made on early diagnosis of pathological derangements, because full value information allows making adequate decisions about subsequent curative measures. It is shown that detection and evaluation of early signs of atherosclerosis appears to be determining factor of efficacy of treatment. In patients without obvious symptoms of ischemic heart disease or at the background of postinfarction cardiosclerosis nuclear cardiology with assessment of myocardial perfusion by single photon emission computed tomography and positron emission tomography (PET) appears rather valuable for assessment of viability even when coronary arteries are unchanged. Important significance for detection of cardiosclerosis has also acquired spiral computed tomography, which allows to reveal calcium in blood vessels. The use of multislice computed tomography in perspective might partially replace coronary angiography especially for assessment of degree of stenoses and patency of grafts. On initial stages of atherosclerosis information on AP structure especially on the presence of inflammatory component is very important. Definite successes become noticeable with application of magnetic resonance tomography for detection of AP. However, probably, further perfection of equipment and methodological approaches with the use of novel contrasts is necessary. In this plane definite successes are achieved by PET and combined examinations by methods of PET/CT integrating advantages of both techniques.
 ...
PMID:[The role of noninvasive methods of investigation in diagnosis of atherosclerosis]. 1826 Sep 42

Coronary artery disease (CAD) remains the leading cause of death in most highly developed countries. According to the WHO, more than 17 million people in the world die of cardiovascular pathology (CVP) annually; of them, more than seven million die of CAD. For the medical service of Russian Federation Armed Forces, CAD and atherosclerosis present an important problem due to their prevalence in military men leading to high levels of morbidity, mortality, labor losses, disability, dismiss rate and disqualification of highly professional officers and generals. Certain factors of military service and extreme factors have been found to increase CAD risk. Until now, the incidence and prevalence of initial forms of CAD in military men of dangerous professions have been studied insufficiently. In order to investigate the prevalence of atherosclerotic cardiosclerosis (ASCS), the effects of risk factors (RF), and prognostication of its development, 267 military men, including 14 men of dangerous professions (pilots, navigators, command post operators), and 153 engineers, technicians and supply officers were examined at Military Hospital No7, Mandryk Military Hospital No 2, and four units of a Space Forces division. The clinico-functional examination revealed ASCS in 53 or 19.8% of the servicemen; its rate increased with age. Only a few cases of ASCS were found in subjects aged less than 30 years; a significant increase in ASCS frequency was noted in 41- to 50-year-old subjects (29.8%); between 51 and 60 years old ASCS was found in 32% of the subjects, which meant only a 2.2% increase vs. the previous age group. Possibly, this could be connected with the fact that at this age initial signs of initial forms of CAD, including ASCS in military men of dangerous professions depended not only on age, conventional RF of CAD, but on occupational hazardous factors as well. Lipid exchange disorder is an important RF for the development and progress of various CVP, CAD in the first place. Timely and correct diagnostics and interpretation of an altered lipid profile as well as assessment of concomitant cardiovascular RF are necessary conditions to organize rational prophylaxis of the most important CVP.
 ...
PMID:[The prevalence of initial stages of coronary artery disease in relation to risk factors in military men of dangerous professions]. 1836 85

The correlation of incidence of hearing loss and concomitant pathologies in civil pilots with auditory analyzer sensitivity to aviation noise and length of service was investigated with the use of two-factor variance analysis w/o repetition. As a result of screening, 335 people (group-1) had only trace of audiometric noise impact; 108 people (group-2) displayed a sustained loss of hearing (chronic sensorineural hearing loss). In the aggregate, data of the investigation evidences that incidence of cardiovascular diseases (atherosclerosis of aorta and coronary arteries, atherosclerotic cardiosclerosis) and sensorineural hearing loss depend reliably on both individual sensitivity to noise and length of service. As for other pathologies, none of factorial criteria revealed itself as the categorical cause of a pathology. The significance and unit input of causative factor into health disorders vary as in type of non-auditory pathology, so length of flight service, and suggest linkage with the time of incipient loss of hearing. The flight personnel with low noise sensitivity and sustained deafness were diagnosed for a broader variety of extra-aural pathologies than the group with incipient hearing disorders. Variation analysis w/o repetition is applicable to evaluation of the risks of somatic pathologies in flight personnel.
 ...
PMID:[Analysis of the extra-aural dependence of hearing disorders in civic flight personnel]. 2012 Sep 12

The cytological technique was used to study autopsy specimens from 39 patients aged 35-85 years. Above the atherosclerotic strips and plaques there were multiple destruction microfoci (MDMs) of endothelial cells (EC), which were divided into three types. EC MDMs were detected in the aortic intima in 79.5% of the patients. A total of 107 MDM of different types were found in 63.2% of cases. A total of 53 MDMs were identified. The detection rate for EC MDMs in the aorta and coronary arteries in acute and recurrent myocardial infarction was 1.3 and 2 times greater than that in large-focal and diffuse small-focal cardiosclerosis. EC microfocal destruction is a sign of progressive atherosclerosis and may be a critical step in the transition from stable endothelized to eroded plaque and thrombosis.
 ...
PMID:[Endothelial cell changes preceding the formation of intimal erosions in coronary arteries and aorta in atherosclerosis in humans]. 2073 28

The aim of the work was to study polymorphism of atherosclerosis-related genes in patients with different forms of coronary heart disease (CHD) and chronic cerebral ischemia (CCI) in comparison with long-living subjects. Analysis included the distribution of genotypes and alleles of functional polymorphisms of lipid metabolism genes, viz. HindIII--polymorphism of lipoproteinase (LPL) gene; HhaI--polymorphism of apoE gene; TaqIB--polymorphism of cholesterol ether transfer protein (CETP) gene; I/D--polymorphism of angiotensin converting enzyme (ACE) in CHD and CCI patients of different age groups including long livers and those presenting with different clinical variants of CHD and CCI (FC II-III stable angina of effort, acute myocardial infarction, post-infarction cardiosclerosis, acute coronary syndrome) and control subjects. The study revealed potential molecular-genetic markers for primary and secondary prophylaxis of CHD and CCI. It was shown that DD genotypes of ACE gene, H+/+ of LPL gene and E3E4 are associated with an enhanced probability of myocardial infarction (IM) in CHD patients and can be regarded as high risk markers. The DD genotype is associated with an increased risk of recurrent MI, life-threatening post-IM complications and severe cardiac insufficiency as well as peculiar personality and behavioural traits (animosity and type A behaviour)--psychological risk factors of CHD and predictors of delayed application for medical aid. E2 allele of the ApoE gene and H allele of the LPL gene occur much more frequently in CHD patients aged above 90 years (long livers) than in younger subjects; hence, their value as markers of stable ischemic disease. Protective effect in terms of favourable clinical course of CCI and life expectancy is especially pronounced in subjects with a combination of genotypes with E2E3 + H+H-, E2E2 + H+H-, E3E3 + H-H-genes of ApoE and LPL. B2B2 genotype of CETP gene increases the risk of stable CCI and B1B1 genotype of CETP gene enhances predisposition to cardiovascular pathology.
 ...
PMID:[The genes of atherosclerosis and cardiovascular diseases]. 2186 96

More than 12.1 million people with hypertension (32.2% of the adult population) were registered in Ukraine according to the official statistics on 1 January 2011. The etiopathogenesis of AH is not fully established. Hsp60 is the molecular chaperon/chaperonin, and it's expression significantly increases in response to different kinds of stress (emotional stress, infections, smoking etc). Elevated blood pressure is a mechanical stress to the endothelium and it can induce expression of heat-shock protein 60 (Hsp60) on the endothelial cell surface. Endothelial cells in the vessel wall can be damaged by (auto) immune reactions to Hsp60 present on the cell surface. Elevation of anti-Hsp60 in the circulation is associated with the presence and severity of coronary heart disease, atherosclerosis development, pathological changes in the small vessels of the brain etc etc. Specificity of the anti-Hsp60 antibodies and their role in the pathogenesis of AH has not been established. The aim of this work was to identify the level of anti-Hsp60 antibodies in the sera of patients with AH. 128 patients with AH were examined. To define level of anti-Hsp60 antibodies the sera 39 patients with AH, including 12 clinically healthy individuals (the family history are included the AH cases)--1 group, 19 patients with stage 2--2 group and 8 patients with stage 3--3 group were examined. The control group included 112 blood donors. Anti-Hsp60 antibodies in sera were determined by ELISA and immunobloting (Western-blotting). Recombinant piotein GroEL Escherihia coli (prokaryotic homologue of human Hsp60) and human Hsp60 were used as antigens. Average of levels of antibodies against GroEL and human Hsp60 in the serum of all groups twice exeeded the value of the control (P < 0.001). Antibodies to prokaryotic Hsp60 were prevailed in patients with AH. The seropositive serum to Hsp60 were detectived in patients, that had the risk of the AH complications by ELISA and immunoblotting. In addition, highly reactive IgG anti-Hsp60 antibodies purified by affinity chromatography from human sera of patients with AH recognized GroEL and human Hsp60 in immunoblotting. Elevated levels of anti-Hsp60 antibody in sera of patients with AH stage 3 correlated with pronounced changes in the target organs such as a massive recurrent hemorrhage into the retina, acute ischemic stroke, cardiosclerosis and angionephrosclerosis. It may indicate the involvement of anti-Hsp60 antibodies in the development of the target organ damage.
 ...
PMID:[ANTI-Hsp60 ANTIBODIES IN ARTERIAL HYPERTENTION DIFERENT DEGREE OF SEVERITY]. 2682 38


<< Previous 1 2 3 Next >>