Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The relative volume of myocardial fibers, connective tissue cells, capillaries, interstitial space and surface area of the myocardial fibers and capillaries per tissue volume unit of the myocardium were measured during diffuse cardiosclerosis under conditions of experimental atherosclerosis. A significant decrease in the relative volume of the myocardial fibers alone with a concomitant increase of the extracellular space of the stroma were demonstrated.
 ...
PMID:[Quantitative interrelationship between the parenchyma and the stroma of the rabbit myocardium in atherosclerotic cardiosclerosis]. 7 Nov 76

Standard and submaximal physical load tests were contrasted in studying the functional state of the cardio-respiratory system in healthy individuals and in patients with coronary atherosclerosis, post-infarction cardiosclerosis, mitral lesions and cardiac-pulmonary insufficiency. The application of physical load tests of different types is shown to be instrumental in obtaining a mutually complementary information about the function of the cardiac-respiratory system and the degree of pulmonary and cardiac decompensation. The authors attach great importance to determining the ratio of an actual oxygen uptake to its proper values and suggest using this indicator, called by them performance capacity index, in quantitative appraisal of physical capacity to perform work. In recognizing early stages of circulatory insufficiency of considerable interest is determining the ratio of the venous blood concentration of lactate, pyruvate and some other biochemical factors to the amount of work done.
 ...
PMID:[Early diagnosis of cardiac insufficiency with the spiroergometric method]. 123 18

As many as 103 men who suffered myocardial infarction were examined for the clinical and functional manifestations of cerebral circulatory disorders as well as for the coronary heart disease at rest and during bicycle ergometry. The majority of the patients with postinfarction cardiosclerosis were found to have changes in the rheoencephalograms, augmenting with physical exercise. Those changes were most pronounced in patients with the clinical manifestations of atherosclerosis of cerebral vessels and in the presence of angina pectoris. The simultaneous recording of the rheoencephalogram and electrocardiogram during bicycle ergometry can be used for an all-round estimation of the reserves of cerebral and coronary circulation in patients suffering from coronary heart disease and elaboration of rehabilitation measures.
 ...
PMID:[Rheoencephalography as an indicator of disorders of cerebral circulation in patients after myocardial infarction]. 132 77

The lipid spectrum was examined in 77 Moscow male residents aged 30-60 years in winter and in summer. The examinees were divided into 4 groups: (1) healthy subjects; (2) patients with arterial hypertension; (3) those with post-infarction cardiosclerosis; (4) those with the two abnormalities. The levels of total cholesterol, triglycerides, high density lipoprotein cholesterol, low and very low density lipoprotein cholesterol, and circulating immune complex cholesterol were measured. All the groups were demonstrated to have lower cholesterol and low density lipoprotein levels in summer than in winter, which should be taken into account in the diagnosis and treatment of atherosclerosis-associated diseases.
 ...
PMID:[Seasonal variations of the lipid spectrum in patients with post-infarction cardiosclerosis and arterial hypertension]. 175 81

To elucidate the nature of lipid defects in patients with diabetes mellitus (DM) concurrent with acute myocardial infarction (MI), the study was undertaken to examine the serum concentrations of total cholesterol, triglycerides, alpha- and beta-lipoproteins with DM in the presence of acute MI. 40 non-diabetic patients with acute MI, 23 diabetics with postinfarct cardiosclerosis, and 17 non-insulin-dependent diabetics without signs of coronary atherosclerosis. Urinary epinephrine and norepinephrine excretion was additionally determined in the acute period and 3-4 weeks after therapy. Homogeneous lipid metabolic parameters were found in CHD patients with and without DM and when transient hyperglycemia developed. The patients with acute MI exhibited some increase in lipid consumption to satisfy the energy need for the cardiovascular system, this being true for triglycerides in DM patients. The DM patients who showed low triglyceride levels had more frequently transmural MI and MI complicated with heart failure. Obesity and familial histories of DM and CHD in DM patients with acute MI were ascertained to be accompanied by reduced serum alpha-lipoprotein concentrations.
 ...
PMID:[The nature of changes in lipid metabolism in patients with diabetes mellitus associated with ischemic heart disease]. 227 41

Combined estimation of signs of cerebral circulatory disorders, the state of microcirculation and a degree of CHD was done in 111 male patients after myocardial infarction. Disorders in the system of the terminal bed which corresponded to the severity of clinical manifestations of disorders of coronary and cerebral circulation, were revealed in the overwhelming majority of the patients. The most noticeable changes in the terminal blood flow were observed in patients with marked clinical signs of atherosclerosis of the cerebral vessels. They also had a more severe course of postinfarction cardiosclerosis. Since noticeable microcirculatory disorders were detected in all these patients, it could be assumed that they were suggestive of the presence and severity of atherosclerosis. Symptoms of CNS lesion developed against this background and depended on the features of cerebral circulation and some other factors.
 ...
PMID:[Correlations of clinico-functional manifestations of cerebral arteriosclerosis and microcirculatory indicators in patients with a history of myocardial infarction]. 229 Mar 27

The results of the catamnestic study of case reports and records of postmortem examination of 102 patients with bronchial asthma (BA) aged 47 to 88 years who died at a general hospital during 1976-1988 indicate that in the overwhelming majority of cases, there took place death "with asthma" rather than death "from asthma". At the same time the dominant pathology was coronary heart disease (acute coronary failure, myocardial infarction, progressive heart failure associated with atherosclerotic and postinfarction cardiosclerosis). Emphasis is laid on the fact that according to the autopsy data, the rate of the recognized stenosing atherosclerosis of the coronary arteries considerably exceeded the number of cases of coronary heart disease documented clinically (typical angina pectoris of effort, significant macrofocal myocardial infarction). The characteristic features of the group under observation included an unexpectedly frequent combination of BA and malignant neoplasms (24 cases), including lung cancer in 13 of these cases.
 ...
PMID:[An analysis of the causes of death in bronchial asthma patients (based on the data from a 13-year prospective observation)]. 236 7

Morphogenesis of the chronic disturbance of lymph effluence from the heart was studied in the course of experimental alimentary atherosclerosis and in combination of atherosclerotic dyslipoproteinemia with recurrent coronary failure. Stereoangioscopic analysis, semithin sections and electron microscopy of different areas of the heart lymphatic network injected with fine corpuscular substances were used. Type and dynamics of the development of main pathologic and adaptive changes in the heart lymphatic bed are established. Systemically repeating coronary crises aggravate the pathologic restructuring of the lymphatic bed limiting the efficiency of the compensatory adaptive processes. The results indicate that the chronic lymphostasis and lymphogenic cardiosclerosis stimulated by atherogenic dyslipoproteinemia and coronary failure represent an essential factor in the progression of a chronic ischemic heart disease.
 ...
PMID:[The morphogenesis of chronic failure of the lymph outflow from the heart in dyslipoproteinemia and recurrent myocardial ischemia]. 239 12

Initial manifestations of cerebrovascular pathology (CVP) in the presence of arterial hypertension (n-26) and atherosclerosis (n-428) were combined with various cardiovascular disorders ranging from cardialgia to coronary heart disease in 67.4% of the patients. Cardial disturbances were expressed as an atypical pain syndrome in 47% and as angina of effort and postinfarction cardiosclerosis in 23.2% of the patients. Electrocardiographic changes were elicited in 52.6-62% of the patients. Bicycle ergometry revealed a decrease in all parameters of tolerance to physical exercise. Disorders of the general and cerebral hemodynamics were more pronounced in atherosclerotic patients; at the first stages of cerebral pathology they predominantly presented the normokinetic type of the hemodynamics (40.6%) while its more marked forms were associated with the hypokinetic type of the circulation (52). The early diagnosis of cardial and hemodynamic disorders is necessary for the presention of acute disturbances of the cerebral circulation.
 ...
PMID:[Cardiac and hemodynamic disorders in the pathogenesis of the initial manifestations of cerebrovascular pathology]. 293 10

Investigation of the extracellular matrix composition of the left heart ventricle was carried out on autopsy material of subjects, aged from 60 to 70 years, in a number of cases, including: (1) tissue without cardiosclerosis; (2) granulation tissue formed 2 weeks after infarction; (3) post-infarctial fibrous scars; (4) diffuse cardiosclerosis in consequence of stenotic coronary atherosclerosis. Cryostat sections treated with highly specific antibodies to fibronectin and types I, III, IV and V collagens were examined by the indirect immunofluorescence technique. Fibronectin and the mentioned collagenous proteins were detected in the extracellular matrix of granulation tissue. In contrast, fibronectin and collagen type IV were not revealed in post-infarctial fibrous scars. Collagen types III and V were diffusely distributed in fibrous tissue, whereas collagen type I was demonstrated to accumulate preferentially in the deeper regions of post-infarctial scars. Fibronectin and collagen types I, III, V, but never type IV, were also found in the connective tissue in diffuse cardiosclerosis. The significance of type V collagen in the extracellular matrix is discussed.
 ...
PMID:Participance of fibronectin and various collagen types in the formation of fibrous extracellular matrix in cardiosclerosis. 306 29


1 2 3 Next >>