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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Morphogenesis of the chronic disturbance of lymph effluence from the heart was studied in the course of experimental alimentary atherosclerosis and in combination of atherosclerotic dyslipoproteinemia with recurrent coronary failure. Stereoangioscopic analysis, semithin sections and electron microscopy of different areas of the heart lymphatic network injected with fine corpuscular substances were used. Type and dynamics of the development of main pathologic and adaptive changes in the heart lymphatic bed are established. Systemically repeating coronary crises aggravate the pathologic restructuring of the lymphatic bed limiting the efficiency of the compensatory adaptive processes. The results indicate that the chronic lymphostasis and lymphogenic cardiosclerosis stimulated by atherogenic dyslipoproteinemia and coronary failure represent an essential factor in the progression of a chronic ischemic heart disease.
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PMID:[The morphogenesis of chronic failure of the lymph outflow from the heart in dyslipoproteinemia and recurrent myocardial ischemia]. 239 12

In order to study the long-term effect of impaired lymphatic drainage on the mechanical properties of the arterial wall, cylindrical femoral artery segments from 10 mongrel dogs after 2 weeks of hindlimb lymphatic occlusion were subjected to in vitro mechanical test and compared with the contralateral, sham-operated segments. Smooth muscle contraction was induced by norepinephrine (7.4 X 10(-6) M) and smooth muscle relaxation by papaverine (1.6 X 10(-4) M). As a result of 2 weeks of lymphatic occlusion, wall thickness increased from 243 +/- 18 to 343 +/- 35 microns (P less than 0.02), inner radius decreased from 1.69 +/- 0.11 to 1.42 +/- 0.12 mm (P less than 0.01) and elastic modulus decreased from 1.23 X 10(6) to 0.55 X 10(6) N/m2 (P less than 0.01), when determined at 100 mm Hg (13.3 kPa) intraluminal pressure and with relaxed smooth muscle. The contractile apparatus was able to produce active strain in the vessels with lymphostasis and at physiological pressures not significantly different from the controls (0.89 +/- 0.02 vs. 0.91 +/- 0.02), but at significantly lower levels of tangential stress. Active stress decreased significantly. This study shows that a reorganization of the vessel wall mechanical force-bearing elements occurs in lymphostasis, which, in some respects, resembles the mechanical alterations found in different forms of atherosclerosis.
Atherosclerosis 1989 Aug
PMID:Effect of two week lymphatic occlusion on the mechanical properties of dog femoral arteries. 278 7