Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

On the basis of a pathomorphological and biochemical study of 22 cases with focal hemorrhages in atherosclerosis the author detected a contraction of nerve cells, adipose infiltration, "shadow-cells", a deposit of ferrum in the cytoplasma. The swelling of myelinic fibres was detected more often than hypermyelinization, fragmentation and demyelinization. Glia changes consisted in ameboid transformation and clasmatodendrosis. The maximum increase of the cholesterin amount was observed in pons varoli. Medulla oblongata and dentate nucleus and the minimum--in the cerebellar cortex and cerebrum hemispheres. The subcortical modes according to cholesterin growth and amount occupy the middle place. The connected cholesterin makes up 2/3 of the general amount.
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PMID:[Pathohistologic and biochemical changes in the brain in atherosclerosis with hemorrhagic foci]. 89 18

We examined the effect of chronic social stress, similar to that endured by humans, on lipid metabolism of mice. The activity of the lipoprotein lipase (LPL) enzyme increased in adrenals, while in plasma it diminished significantly. Hepatic lipase (HL) was strongly affected in liver and adrenal glands, increasing four-fold and three-fold, respectively. At the same time, scavenger receptor class-B type-I (SR-BI), which are considered the high-density lipoprotein (HDL) receptor in the liver, increased significantly. Although the adrenals do not synthesise HL, the increase in HL may facilitate the uptake of HDL cholesterol for the synthesis of corticoids, which increase significantly following chronic stress. The volume of adrenal glands in control animals was significantly higher than in stressed animals (1.23+/-0.12 mm3 versus 0.29+/-0.06 mm3, p<0.001), corresponding with the weight difference of these organs. Medulla volume was also different in the two groups (0.27+/-0.10 mm3 versus 0.04+/-0.02 mm3, p<0.05). Despite this, corticosterone in plasma was significantly higher in stressed animals. Our results shows, for the first time, the effect of chronic social stress on lipid metabolism in general, and in particular on the SR-BI receptor and HL, which is directly involved in cholesterol reverse transport.
Atherosclerosis 2007 Nov
PMID:Social stress profoundly affects lipid metabolism: over-expression of SR-BI in liver and changes in lipids and lipases in plasma and tissues of stressed mice. 1722 14