Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Using a novel method of electrophoresis, patients with atherosclerotic and hypertonic dyscirculatory encephalopathy were examined for protein fractions of their blood serum. Various kinds of dysproteinemia and dyslipoproteinemia were recorded, with their manifestations being particularly pronounced in cerebral atherosclerosis with the syndrome of arterial hypertension. Clinical improvement following the therapy was usually accompanied by the normalization of the protein spectrum of blood serum. The results obtained may be utilized in the differential diagnosis and the evaluation of the therapy efficacy.
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PMID:[Serum protein fractions in patients with dyscirculatory encephalopathy in atherosclerosis and hypertension]. 670 69

Lipid-protein relationships were studied in 155 men and women (mean age 48/9 +/ -0.6 years) with CHD (stable angina of effort) and MS. The frequency of concomitant arterial hypertension in men/women was 100%, aortic atherosclerosis 49.7/24.5%, athersclerosis of lower leg arteries 14.8/0%, chronic obstructive pulmonary disease 27.7/5.2%, locomotor disorders 25.8/14.8%, hepato-biliary diseases 24.5/17.4%, gastro-duodenal disorders 16.8/3.2%, hepatic problems 10.5/26.7%. Heterogeneity of lipid-protein homeostasis was documented. Evaluation of dysproteinemia, besides dyslipidemia, is crucial for estimating activity of inflammation as acute or chronic. Patients with CHD and MS need therapy not only of these conditions but also of concomitant diseases taking into account their phases (exacerbation, remission) and results of dynamic observation. Such approach ensures prevention of progression of combined pathology and improvement of patients' quality of life.
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PMID:[The role of lipid-protein interplay in the development of atherogenesis during coronary heart disease and metabolic syndrome]. 2301 71