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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors study the alterations of the senile brain: cerebral atrophy due to neuronal loss, degenerative alterations of neurons, and vascular and ischemic alterations, including atherosclerosis, amyloid angiopathy, and lacunae.
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PMID:[Lesions in senile brain: an anatomic study (author's transl)]. 74 Jan 70

Computerized tomography of the head was done in 5021 patients aged 21 to 81 years from various neurological, neurosurgical and neurotraumatological indications. Brain atrophy as an only finding (primary) was noted in 11.5%- and in 5.4% of cases it was associated with other changes. The neurological-radiological correlations were established in 200 cases of primary strophy. History data included: headaches in 54.5%, dizziness in 15.0%, epilepsy in 24.5%. Objective examination showed: slight hemiparesis in 37.5%, spastic-atactic gait disturbances in 31.5%, isolated damage to the corticospinal tracts with signs limited to one side of the body was more frequent in cortical atrophy, and these signs associated with ataxia were more frequent in subcortional atrophy. The authors explain this as a loss of cortical cells or damage to the paraventricularly coursing nerve fibres. A probable aetiology of "primary" atrophy was established in 405% of cases (hypertension, atherosclerosis, minor craniocerebral trauma). No signs or neurological syndromes were observed which could be regarded as more or less characteristic of brain atrophy.
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PMID:[Brain atrophy: radiological-neurological correlations]. 213 53

We examined the chronic effect of smoking on brain atrophy quantitatively with computed tomography (CT). Study was performed on 159 smokers and 194 non-smokers from 40 to 69 years old with neither neurological nor focal abnormality in brain CT. Brain atrophy index (BAI) which was a quantitative marker of brain atrophy reported previously, was calculated from each pixel of brain CT. There was a significant age dependent increase of BAI in both non-smokers and smokers. Smokers showed a significant increase in BAI (atrophic) compared to non-smokers in three age groups, 50-54, 55-59 (p less than 0.01, both) and 65-69 (p less than 0.05). In the male, the mean BAI became high when the smoking index increased (p less than 0.01). The systolic blood pressure and serum triglycerides of smokers were significantly higher than the non-smokers (p less than 0.05 and p less than 0.01). It was suggested that age-related brain atrophy was increased by chronic smoking through advanced atherosclerosis.
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PMID:Age-related brain atrophy enhanced by smoking: a quantitative study with computed tomography. 344 22

A 29-year-old man with Cockayne's syndrome (CS), presenting reversible ischemic neurological deficit is reported. In his past history, hearing disturbance developed at 6 years old and visual disturbance at 12 years old. His parents have consanguinious marriage. He came to our hospital complaining of right-sided hemiparesis and speech disturbance. He was 115.8 cm tall and his weight 20 kg. The characteristic manifestation of CS, i. e., dwarfism, mental retardadation, cachectic feature, retinal atrophy, neural deafness and calcification of bilateral basal ganglia were all noticed. A CT scan on admission revealed marked brain atrophy as well as the intracranial calcifications, while no lesions compatible with his neurological findings were detected. Cerebral ischemic state was mostly suspected. Following up with conservative therapy by the use of fibrinolytic agent, his neurological deteriorations disappeared on the 4th hospital day. Cerebral angiograms showed stenotic lesions of both C1-C2 portion of the left internal carotid artery and the right middle cerebral artery, and the aneurysm in the right internal carotid artery. Such atherosclerotic vascular change as observed in the cerebral angiograms in this case have progressed rapidly for his age. In this case, diabetes mellitus and hyperlipoproteinemia such as increased total cholesterol, increased triglyceride, decreased HDL and increased apoprotein B and C II were complicated for the risk factor of the atherosclerosis. It's controversial that early progress of atherosclerosis is due to ideopathic original feature of CS or to the secondary change from these complications.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Cockayne's syndrome presenting cerebral ischemic attack: case report]. 379 Mar 68

The association of atherosclerosis with brain atrophy was studied in 101 subjects (75 men and 26 women) using computed tomography (CT). A calcification index (CI) was calculated as an indicator of atherosclerosis in the abdominal aorta: the calcified portion along the entire circumference of the abdominal aorta X 80. Both the cerebrospinal fluid (CSF) space volume and the volume percentage of the CSF space to the cranial cavity [brain atrophy index (BAI)] were calculated as indicators of brain atrophy. The CSF space volume increased with increasing age after the 70s. The BAI increased with increasing age after the 60s. Both the CSF space volume and the BAI in the 70s were 1.8 times those in the 40s. The CI increased with increasing age after the 50s very rapidly, and the CI in the 70s was 54 times that in the 40s. Both the CSF space volume and the BAI were greater in atherosclerotic (CI greater than or equal to 3.0) than in nonatherosclerotic (CI less than 3.0) subjects in the 60s and the 70s.
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PMID:Association of atherosclerosis with increased atrophy of brain matter in the elderly. 395 Feb 98

Results of clinico-morphological and biochemical examinations of 66 autopsy cases are presented. At lifetime the deceased were suffering from atherosclerosis: 16 of them showed no psychotic disturbances; 14 had a pseudoparalytic, 20 a lacunar, and 14 a senile-like form of dementia. With the use of histological staining 22 brain specimens were examined. The biochemical examinations included determinations of total cholesterol, cholesterol fractions, total lipid phosphorus, lecithine, sphingomyelin, phosphatidyl-ethanolamine and diphosphoinositide. It has been found that the process of brain atrophy has a certain relation to the psychotic symptoms and shows a progress from the first to the last group. Qualitative and quantitative changes of lipids are manifest. The content of phospholipids, and, first of all, lecithine, drops, the content of total cholesterol rises, and bound cholesterol appears. Atherosclerosis is a disease at the basis of which there are persistent disturbances of lipid metabolism and biosynthesis of brain lipids.
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PMID:[Pathohistologic and biochemical changes in the brain in atherosclerosis and atherosclerotic dementia]. 741 33

Because cerebral atrophy and white substance of the cerebral hemispheres became typical findings at NMR-tomography of the brain in Parkinson's disease, the authors initiated a study to quantify the observed defects. A combination of neurological, neuropsychological and NMR-tomography methods with addition of formalized scales has been utilized. The severity of cerebral atrophy and that of neurological and psychic disorders were related. Internal atrophy was more frequently observed in older patients, the external one was more characteristic for patients with systemic atherosclerosis. Multiple focal lesions of the white substance were encountered in associated arterial hypertension and was present in all the patients with distinct cerebral atrophy. Diffuse lesions of the white substance (leukareosis) showed no relationship to any of the factors studied.
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PMID:[Magnetic resonance tomography of the brain in Parkinson's disease]. 816 Apr 96

CT images of leuko-araiosis in brain slices were quantified according to volumes of reduced Hounsfield units in frontal periventricular white matter in groups of elderly patients with multi-infarct dementia (MID, n = 23) and dementia of the Alzheimer type (DAT, n = 16). Volumes of leuko-araiosis, estimates of atrophic cerebral tissue, and local cerebral perfusion utilising inhalation of xenon gas as the indicator were correlated on the same CT slices. Ratios of frontal leuko-araiosis to total brain tissue volume were similar for patients with MID and DAT (mean 5.7 (SD 2.1)% v 6.5 (3.2%)), and both were significantly greater than ratios in elderly normal volunteers (3.1(1.3)%, 0 < 0.001). Cerebral atrophy (measured as the ratio of volumes of cerebrospinal fluid to total brain area) for DAT patients was 17.0 (6.7)%, which was greater than for MID patients (12.5 (5.4)%; p < 0.05) and both types of patients showed more cerebral atrophy than did age matched, elderly normal subjects. Cerebral perfusion was decreased in all regions measured in patients with MID and DAT compared with elderly normal subjects. Multi variate regression analyses correlated frontal leuko-araiosis with reductions of local cerebral blood flow in subcortical grey matter (p < 0.025) in patients with vascular dementia but not in those with DAT. These quantitative measures implicate decreased perfusion due to atherosclerosis in territories supplied by the deep penetrating cerebral arteries in the pathogenesis of leuko-araiosis in patients with vascular dementia, but suggest a different pathogenesis for leuko-araiosis in Alzheimer's disease.
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PMID:Correlations of leuko-araiosis with cerebral atrophy and perfusion in elderly normal subjects and demented patients. 843 7

Pure cortical arterial injury is defined as an acute subdural hematoma (ASDH) due to micro laceration of the cortical artery without cerebral contusion. We analyzed this peculiar ASDH in 14 cases. This ASDH has the following characteristics. 1) This disease develops in elderly persons after minor head trauma. 2) After a relatively long lucid interval, the consciousness level of these patients decreases rapidly to semicoma or deep coma. 3) Brain atrophy, atherosclerosis and a tendency to bleed (drugs, hemodialysis, thrombocytopenia, etc.) are involved in this hematoma. 4) The clinical outcome is generally poor because of systemic complications. The authors infer the mechanism of pure cortical arterial injury to be as follows. Minor hemorrhage occurs due to direct impact damage after trivial head trauma, but physiological hemostatic actions are set in motion. After a lucid interval, rebleeding from the injured cortical artery causes massive subdural hemorrhage.
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PMID:[Acute subdural hematoma due to pure cortical arterial injury: analysis of 14 cases]. 933 Mar 92

Cerebral magnetic resonance imaging (MRI) has demonstrated a high prevalence of infarct-like lesions, white matter hyperintensities, and evidence of cerebral atrophy in older adults. While these findings are generally believed to be related to ischemia and atherosclerosis, their relationship to atherosclerosis in the carotid arteries remains to be explored. Study subjects were part of the multicenter Cardiovascular Health Study, a cross-sectional study of 3502 women and men >/=65 years of age undergoing cranial MRI and carotid ultrasonography. MRI infarcts were detected in 1068 participants (29.3%) and measurable carotid plaque in 2745 (75.3%). MRI infarcts, ventricular and sulcal widening, and white matter score were strongly associated with carotid intimal-medial thickness (IMT) and stenosis degree after adjustment for age and sex (all P<0. 01). Associations with plaque characteristics were less strong and less consistent; MRI infarcts were weakly associated only with surface irregularity, and ventricular size was weakly associated only with lesion density (both P<0.04). In contrast, sulcal widening was strongly related to plaque characteristics, with scores being higher in those with heterogeneous and irregular plaque (both P<0. 009). Adjustment for other risk factors, and for carotid IMT/stenosis, removed associations of MRI findings with plaque characteristics except for weak relationships remaining between MRI infarcts and surface irregularity and between sulcal score and heterogeneous plaque (both P<0.03). MRI abnormalities show strong and consistent relationships with increasing carotid IMT and stenosis degree but less strong associations with plaque characteristics, especially after adjusting for IMT and stenosis.
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PMID:Relationships of cerebral MRI findings to ultrasonographic carotid atherosclerosis in older adults : the Cardiovascular Health Study. CHS Collaborative Research Group. 997 19


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