Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A neurolinguistical analysis of speech by the articulation method of E. N. Vinarskaya in patients with senile dementia (4 cases) and its combination with cerebral atherosclerosis (4 cases) permitted to detect a primary "level" defect in the speech functional system. The study demonstrated a prevalent lesion of the lower, gnostico-praxis level in combination of 2 processes and prevalence of disorders of a higher, phenological (lingual)--in cases of "pure" senile dementia. A comparison of the clinical stage of the disease and the level of lesion in the speech functional system showed a possibility of an unusual (from lower to higher) destruction in patients with senile dementia with preservation of the "ordinary" regularity from the higher to lower) in memory and intellectual impairment. The detected characters of a primary speech defect in senile atrophy permitted to allocate speech disorders in such cases to genuine aphatical (focal)--the syndrome of superior-temporal area of the left hemisphere of the temporal-acoustical aphasia according to A.R. Luria. It is demonstrated that in this defect there is an involvement and disturbance of the subcortical structures as an expression of a diffusion of the destructive process.
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PMID:[Speech disorders in senile dementia]. 69 16

A 77-year-old woman was admitted because of progressive vertigo, nausea and a dysarthric speech disorder. The patient's history of diabetes mellitus, hypertension and hypercholesterolaemia, and the finding of murmurs over peripheral arteries at physical examination led to a presumptive diagnosis of cerebellar ischaemia in the context of generalized atherosclerosis. However, the diagnosis was revised when bilateral cerebellar infarction was demonstrated radiologically, and a biopsy of a temporal artery revealed giant cell arteritis. Despite treatment with prednisone (60 mg daily) the patient's neurological condition deteriorated, and she succumbed several months later to pneumonia. The case illustrates the pitfalls in the diagnostic approach of elderly patients with multiple pathology and it also emphasizes that in an elderly person with high erythrocyte sedimentation rate (> 100 mm in the first hour) temporal arteritis should be ruled out as soon as possible to prevent further neurological damage.
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PMID:[Clinical thinking and decision making in practice. An elderly patient with vertigo and high sedimentation rate]. 1066 48