Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The thickness of the sclera has been morphologically examined in 165 cadaver eyes and the thickness of the reticular plate (RP) in 68 eyes in open-angle glaucoma, atherosclerosis, and involution. The measurements have shown that the sclera and RP are thinner in atherosclerosis than in the control, this process being more manifest in the RP. The RP supporting characteristics deteriorate even in vascular abnormalities. Open-angle glaucoma is associated with a most significant thinning of the sclera (t up to 5.33), but when this process develops far, the thinning ceases (t = 0.06). RP thinning is more marked (t = 2.2 = 7.58) and does not cease in case of a far-developed process. The values of the pressure on the posterior segment of the eye in health and in glaucoma are presented; this pressure is drastically elevated in glaucoma, which fact may explain the stretching of the entire posterior segment (of the sclera by 1.5 times and of the RP by 8.5 times). Since the mechanical properties of the RP are poor and the plate virtually disappears, the optic nerve is devoid of its support.
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PMID:[Quantitative biochemical shifts in the connective tissue of the rear section of the eyeball in glaucoma and atherosclerosis]. 272 63

The clinical message of this editorial is that age-related macular degeneration may be a vascular disorder. It may be a manifestation of the hemodynamic consequence of the process of lipoid infiltration that, when it involves other organs such as those of the cardiovascular or cerebrovascular systems, is called atherosclerosis. The hemodynamic model presented here postulates that in age-related macular degeneration, the increase in resistance to the flow of blood in the choroid is caused by an age-related and diet-related decrease in the compliance of the sclera. It proposes that the form of age-related macular degeneration produced may depend on the relative resistances of the ophthalmic and cerebral circulations. A decrease in perfusion, leading to the atrophic form of age-related macular degeneration, is the outcome if the resistance of the cerebral circulation is relatively lower than that of choroid. Conversely, a relatively greater increase in the increase in the hydrostatic pressure in the choroidal vessels, leading to the exudative form of the disorder.
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PMID:A hemodynamic model of the pathogenesis of age-related macular degeneration. 1107 46

THE GOAL OF THIS STUDY: description of morphogenesis aortic valve stenosis in the senile and vice atherosclerotic aortic valve and definition inflammatory processes in them, improving pathology-anatomic diagnostic, macro- and microscopic examination of the stage of development of atherosclerotic plaques in the operating material fragments of aortic valve on the basis of morphological (histochemical and immunohistochemical studies by using markers CD31, VEGF) and idiopathic characteristics of atherosclerotic plaques, the differential diagnosis of the degree of calcification of the aortic valve in the atherogenic and idiopathic aortic stenosis. Calcification in senile aortic stenosis is characterized by three main parameters: infiltration of inflammatory cells, while senile origin stenosis observed the potential growth of angiogenesis. In endothelial walls of the aortic valve imunnhistochemicaly revealed high expression of endothelial and panendothelial growth factors. We have investigated aortic valve leaflets which were obtained from patients undergoing aortic valve replacement. Total 65 Patients (there age were from 54-84 year), 35 male and 30 female. The results indicate that senile lesion of aortic valve leaflets have several features including: sclera-fibrosis, inflammatory cell infiltration, new vessels formation and calcification which also are present in clinically stenotic valves cased by atherosclerosis. As a result of overlap clinical factors within atherosclerosis and senile calcific disease may be determined such as factors contributing progress of obstruction and vice versa, morphological pre-conditions for occlusion of thrombosis and blood vessels that will become significant part of strategy on treatment of wall structure stability and post-operation treatment.
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PMID:HISTOLOGICAL AND IMMUNOHISTOCHEMICAL STUDIES OF ATHEROSCLEROTIC AND SENILE CALCIFIC AORTIC VALVE STENOSIS. 2617 42