Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An alternative means of investigating atherosclerosis is suggested in the hope that this will lead to preventative and therapeutic measures more successful than current approaches. A putative link between arterial atherosclerotic lesions and neoplasia, suggesting that arterial plaques are monoclonal in origin, is discussed. If plaques do minic a neoplastic process, it is possible to look at many conventially accepted aspects of arterial disease in a new light. This is particularly the case with the role of diet, smoking and how the disease might be prevented or treated at an early stage or how the process might be reversed.
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PMID:Neoplasia of the arterial wall: role in atherosclerosis. 740 37

The results of X-ray examination of 25 (2.8%) out of 899 patients were analyzed. The changes of their neck mass were due to the conditions of non-tumoral and non-inflammatory nature. These states were not always clinically clear and were not infrequently considered as a neoplastic process. The causes of them can include developmental anomaly of neck organs, post-radiation and postoperative alterations, atherosclerosis, degenerative-dystrophic alterations in the cervical portion of the vertebral column etc. To establish the character of the neck mass changes it is necessary to perform a complex radiation examination, its first and sometimes the only stage being USI. Choice of the following methods (CT, MRT and so on) depends on the results of USI and the clinical picture.
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PMID:[Neck mass changes of the nontumorous and noninflammatory nature: the value of radiodiagnosis]. 1294 3

Atherosclerosis and cancer are chronic diseases considered two of the main causes of death all over the world. Taking into account that both diseases are multifactorial, they share not only several important molecular pathways but also many ethiological and mechanistical processes from the very early stages of development up to the advanced forms in both pathologies. Factors involved in their progression comprise genetic alterations, inflammatory processes, uncontrolled cell proliferation and oxidative stress, as the most important ones. The fact that external effectors such as an infective process or a chemical insult have been proposed to initiate the transformation of cells in the artery wall and the process of atherogenesis, emphasizes many similarities with the progression of the neoplastic process in cancer. Deregulation of cell proliferation and therefore cell cycle progression, changes in the synthesis of important transcription factors as well as adhesion molecules, an alteration in the control of angiogenesis and the molecular similarities that follow chronic inflammation, are just a few of the processes that become part of the phenomena that closely correlates atherosclerosis and cancer. The aim of the present study is therefore, to provide new evidence as well as to discuss new approaches that might promote the identification of closer molecular ties between these two pathologies that would permit the recognition of atherosclerosis as a pathological process with a very close resemblance to the way a neoplastic process develops, that might eventually lead to novel ways of treatment.
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PMID:Atherosclerosis and Cancer; A Resemblance with Far-reaching Implications. 2857 65

The present review aimed to present the research highlights on C1q/TNF-related protein 1 (CTRP1), a member of the recently discovered family of highly conserved adiponectin paralog proteins, C1q tumor necrosis factor-related proteins. CTRP1 plays an important role in regulating body energy homeostasis and sensitivity to insulin. Studies on animal models have shown that it lowers the concentration of glucose. Elevated concentrations of CTRP1 reduce weight gain and diet-induced insulin resistance. CTRP1 limits the extent of ischemia-reperfusion injury in acute myocardial infarction. It inhibits platelet aggregation by blocking von Willebrand factor binding to collagen. In patients with chronic kidney disease, an increase in CTRP1 levels is associated with a lesser degree of disease progression. CTRP1 stimulates aldosterone synthesis in the adrenal cortex by affecting aldosterone synthase expression. In dehydration, an increase in CTRP1 concentration helps to maintain normotension. It participates in processes related to the proliferation and maturation of chondrocytes. It also promotes atherosclerosis, and a surge in its concentration is correlated with a higher cardiovascular risk in patients with coronary atherosclerosis. In vascular smooth muscle cells, it induces the expression of proinflammatory cytokines. An increase in CTRP1 levels is correlated with the progression of the neoplastic process in patients with glioblastoma.
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PMID:C1q/TNF-related Protein 1, a Multifunctional Adipokine: An Overview of Current Data. 3259 Oct 91