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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The results are discussed of a complex neuro-ophthalmological investigation of 439 patients with initial cerebral atherosclerosis. Their neurological characterization and the results of elecrcto-physiological, biochemical, and psychological examination methods are indicated. The opthalmologist had performed the opthalmoscopic examination, biomicroscopy of the vessels of conjunctiva and episclera the opthalmocalibrometry and angiophotometry as well as opthalmodynamometry. The most frequent opthalmological symptoms of initial cerebral atherosclerosis are pointed out. The methods are compared for their diagnostic value.
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PMID:[Ophthalmological characteristics of early cerebral atherosclerosis]. 94 Aug 82

Microcirculation and rheological properties of blood were investigated over time on the basis of the findings of biomicroscopy of the bulbar conjunctiva in 61 patients with different stages of circulatory encephalopathy in the presence of arterial hypertension and atherosclerosis. Rheological properties of blood were changed at all stages of disease. Correlations between the ability of erythrocytes to aggregation and the degree of their intravascular aggregation by the findings of biomicroscopy of the bulbar conjunctiva were not found. The importance of investigation of the intravascular aggregation of erythrocytes and theological properties of blood for assessment of the cerebral vascular microcirculation, control of therapy, and verification of some aspects of the mechanism of action of various drugs was shown.
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PMID:[Status of microcirculation and rheological properties of blood in patients with cerebral circulatory disorders]. 229 Mar 22

Progressive cholesterol deposition frequently occurs in the corneas, tendons, and arteries of those individuals who have hypercholesterolemia. Many investigators have noted histochemical and chemical similarities in the nature of the lipid that accumulates in these tissues. Lipid-soluble dyes have been used to stain hydrophobic lipids such as cholesteryl ester and triglyceride in previous studies of corneal lipid deposits. In this report, deposits of unesterified cholesterol have been detected in the limbal cornea and conjunctiva of hypercholesterolemic rabbits using the fluorescent dye filipin. Whereas, oil red O-stained lipid accumulated both intra- and extracellularly, unesterified cholesterol accumulated extracellularly, similar to its predominant location in tendon xanthoma and atherosclerotic lesions. The source and mechanism by which unesterified cholesterol accumulates in limbal cornea and conjunctiva, tendons, and arteries remains to be determined.
Atherosclerosis 1987 Jan
PMID:Accumulation of unesterified cholesterol in limbal cornea and conjunctiva of rabbits fed a high-cholesterol diet. Detection with filipin. 243 94

The action of trental was studied in 125 patients with initial manifestations of cerebral circulation insufficiency (CCI) secondary to vasomotor dystonia or atherosclerosis. Trental was used in the form of tablets (100 mg 3 times daily) for 60 days. To assess the therapeutic effect of trental, the authors analyzed the time-course of subjective manifestations, parameters of echopulsography of cerebral vessels and biomicroscopy of the conjunctiva, and the data of the total blood count and the rheological properties of the blood. In patients with initial manifestations of CCI trental decreased the cerebral vascular resistance and improved the venous outflow, reduced platelet adhesive and aggregation properties and diminished blood viscosity. It also elevated the spontaneous fibrinolytic activity of the blood. The advisability of selective administration of the drug for treating initial manifestations of CCI was confirmed.
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PMID:[Indications for using trental in the initial manifestations of inadequate blood supply to the brain]. 395 93

We have identified a 44-year-old patient with symmetrically excessive xanthomatosis, called Erdheim-Chester disease (ECD), and simultaneously decreased levels of low-density lipoprotein (LDL) cholesterol. Clinically, this patient presents lipoidgranulomatosis of numerous long and flat bones with involvement of the liver, spleen, pericardium, pleura, thyroid, skin, conjunctiva, and gingiva. However, the patient does not have any signs of atherosclerosis. So far, the underlying defect has not been elucidated. We performed a LDL-apolipoprotein B (apoB) kinetic study in the ECD patient and a normal control to determine the etiology of the low LDL level in ECD. LDL was isolated from both subjects, radioiodinated with either 131I or 125I, and injected simultaneously into the ECD patient and the normal control. Normal and ECD LDL was catabolized at the same rate after injection into the control subject (fractional catabolic rate [FCR], 0.43/d and 0.46/d, respectively). Therefore, LDL isolated from an ECD subject is metabolically normal. In contrast, autologous LDL injected into the ECD subject showed a markedly increased catabolism (FCR, 0.69/d) compared with that in the control subject (FCR, 0.43/d). This is the first report about increased catabolism of LDL cholesterol in a patient.
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PMID:Erdheim-Chester disease: low low-density lipoprotein levels due to rapid catabolism. 932 10

Presented herein are the findings of studying the peculiarities of the systemic and regional haemodynamics in patients with obliterating atherosclerosis of the arteries of the lower limbs. We examined a total of 186 patients with stage I-IV chronic arterial ischaemia of the lower extremities using the following methods: computer-assisted TV microscopy of the vessels of the conjunctiva of the eyeball and of the skin of the lower limbs, laser Doppler flowmetry (LDF) and transcutaneous determination of oxygen tension. Revealed were: spastic, congestive, Presented herein are the findings of studying the peculiarities of the systemic and regional haemodynamics in patients with obliterating atherosclerosis of the arteries of the lower limbs. We examined a total of 186 patients with stage I-IV chronic arterial ischaemia of the lower extremities using the following methods: computer-assisted TV microscopy of the vessels of the conjunctiva of the eyeball and of the skin of the lower limbs, laser Doppler flowmetry (LDF) and transcutaneous determination of oxygen tension. Revealed were: spastic, congestive, spastic-atonic and stasic forms of microcirculatory disorders. It was determined that microcirculatory disorders in obliterating atherosclerosis of the lower limbs are systemic, to be revealed both in the extremities affected and in the conjunctiva of the eyeball. A pathophysiologically substantiated classification of microcirculatory disorders is proposed herein.
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PMID:[Pathophysiological characteristics of microcirculatory disorders in chronic arterial ischaemia of lower limbs]. 1767 71