Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004153 (atherosclerosis)
 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Transluminal angioplasty of brachiocephalic vessels for atherosclerotic lesions is now being performed in selected cases. We have thus far treated 17 cases of vertebral artery stenosis and one case of basilar artery stenosis by intravascular balloon dilatation techniques. Clinical presenting symptoms included vertebral basilar insufficiency, repeated transient ischemic attacks (TIAs), and multiple strokes. We performed successful transluminal angioplasty in 16 patients with marked narrowing (greater than 70%) of the dominant vertebral artery from atherosclerosis. One patient with basilar artery stenosis with tandem atherosclerotic lesions was also treated by angioplasty techniques. Repeat angiography at 3- to 12-month intervals has revealed continued patency at the angioplasty site. Complications occurred in our one patient with basilar artery angioplasty, who suffered a brainstem infarction after treatment, and in one patient who had a TIA after bilateral vertebral artery angioplasty. Two other patients had residual vertebral stenosis but remained asymptomatic after the procedure. All other patients who had successful dilatation were asymptomatic at 6 months to 2 years (mean, 15 months) of follow-up. These initial studies indicate that vertebral artery angioplasty may be effective for treating high-grade atherosclerotic lesions and for improving blood flow to the posterior circulation. Angioplasty of the basilar artery is technically more difficult and has a higher degree of risk because of the many perforating branches supplying the brainstem.
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PMID:Transluminal angioplasty of the vertebral and basilar artery. 296 Feb 22

Among 128 patients operated for atherosclerosis of the internal carotid artery, 83 (59 males, 24 females, mean age 64 years) were controlled by Doppler ultrasonography, spectral analysis and Duplex. They had been submitted to 86 endarterectomies and 5 operations for total occlusion. In 23 cases, the stenosis was asymptomatic. The delay between operation and control varied between 12 and 123 months (mean follow-up: 50.6 months). 75 patients remained asymptomatic, whereas 8 suffered TIAS. Ultrasound examinations revealed 57 normal arteries or with thickened walls (62.6 p. 100), 9 stenoses less than 50 p. 100 (10 p. 100), 14 stenoses more than 50 p. 100 (15 p. 100) among which 8 were reoperated and 11 occlusions (4 failures of desocclusion and 7 postoperative occlusions: 7.6 p. 100). Recurrent stenoses occurred more frequently in females, mean age lower than in the whole group, as has been already reported. They determined minor symptomatology (vertebro-basilar insufficiency in 2 cases, TIA in 1 case). Three postoperative occlusions were acute and gave rise to a severe neurological deficit, whereas the other ones remained generally asymptomatic. These results are compared to reported series. Ultrasonography is a technique of choice to follow endarterectomised patients. The high rate of recurrent stenoses after endarterectomy raises questions about endarterectomy.
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PMID:[Carotid endarterectomy: long-term ultrasonic evaluation]. 304 39

Transient visual loss due to cerebro-ocular vascular disease is a common symptom. The purpose of this paper is to present a unified terminology of the monocular vs. binocular or homonymous types. Lack of proper identification may lead to mis-diagnosis and improper management of these entities. Monocular blurred vision must be investigated since its origin is so commonly due to atherosclerosis of the carotid system. Binocular blurred vision due to vertebro-basilar insufficiency is managed conservatively in almost all instances.
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PMID:The terminology of transient visual loss due to vascular insufficiency. 647 46

Indications for surgery of vertebro-basilar insufficiency are: stenosis or occlusion due to atherosclerosis. The initial parts of carotid, subclavian arteries or brachiocephalic trunk one must frequent involved. From the other hand arterial compression on vertebral arteries (diskopathies or osteopathies) leads to symptoms of cerebral ischaemia. In diagnosis very important are history of disease, physical examination and neurologic assessment. Additional procedures consisted of: color Doppler-scan, transcranial Doppler, cerebral CT-scan and angiography. By-pass of stenotic or occlusive segment of artery is procedure of choice in this disease.
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PMID:[Vertebro-basilar insufficiency syndrome: preoperational diagnosis]. 1022 37