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 77,401 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Diabetes is a chronic disease secondary to the interaction of the hereditary and environmental factors and is characterized by an abnormal secretion of insulin or by an ineffective use of this hormone. The result is the elevation of glycemia rate (N < 126 mg/dl). Untreated hyperglycemia can lead to serious complications like retinopathy, nephropathy, neuropathy, atherosclerosis, foot lesions (ulcer, infections, Charcot's arthropathy), even to amputations. The diabetes is a worldwide pandemic: 150 million people in the world, which will double in the next twenty-five years. The diabetes foots have a tremendous social and economic impact. The mechanisms which are implicated in development of the diabetic foot are the neuropathy and the arteriopathy. Lesions appear in the presence of the triggering factors. Diabetes is a disease in which several specialities are implicated. They should work together when treating these patients. Prevention is essential. The patient must be educated, then the complications of diabetes can be avoided.
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PMID:[Diabetic foot]. 1709 96

This article reviews the published data on the utilization of [(18)F]Fluorodeoxyglucose (FDG) positron emission tomography (PET) and PET/CT imaging in patients with complicated diabetic foot. Three areas have been identified where FDG-PET/CT can have an important role in the clinical decision making process of this disease and could be helpful to the podiatricians if found accurate: (a) Diagnosis of deep soft tissue infection and osteomyelitis (OM), (b) differentiating Charcot arthropathy from OM and (c) evaluating the ischemia/atherogenesis component in a particular case. The main focus of the research initiatives involving PET in the setting of diabetic foot syndrome has been its possible role in the reliable diagnosis or exclusion of OM. The literature on the efficacy of FDG PET in reliably diagnosing or excluding OM in diabetic foot is divided with two groups of results; four studies emphasizing the potential usefulness and two depicting relatively low sensitivity of this modality. The combined PET/CT fusion approach appears better than FDG PET imaging alone owing to superior anatomical localization and thereby better differentiation of soft tissue infection and bone. With the establishment of clinically functioning PET/MRI units, it is essential to conduct further research studies designed to investigate the ability of this modality as the most optimal one-stop shop diagnostic imaging technique for the management of patients with diabetic foot. A relatively less explored area is the role of FDG PET in assessing atherosclerosis in the large vessels of the lower limb that could help in studying the ischemia component and its contribution in the development of diabetic foot. Further research is required in this direction.
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PMID:FDG PET and PET/CT Imaging in Complicated Diabetic Foot. 2715 33