Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0004135 (ATM)
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Human Gene/Protein
QSCN6 11.3
TNFRSF6 protein 11.3
p13MTCP1 protein 11.3
phosphoinositide-3-kinase adaptor protein 1 11.3
AT1 11.3
KIAA0930 11.3
UCC1 11.3
KIAA0406 11.3
ring finger protein 123 11.3
C5orf45 11.3
peroxisomal biogenesis factor 3 11.3
E14/NPAT 11.3
zinc finger protein 644 11.3
ZBTB22 11.3
CABIN1 protein 11.3
hypothetical protein FLJ11151 11.3
C12orf60 11.3
X-ray radiation resistance associated 1 11.3
ATM 11.3
KIAA1467 11.3
ATM protein 11.0
AT2 10.8
C11orf65 10.7
ATLD 10.5
TRRAP protein 10.5
ATMIN 10.5
Schlafen family member 11 10.3
GUCY1B2 10.3
breast and ovarian cancer susceptibility protein 1 10.3
ATP synthase subunit a 10.3
WDR17 10.3
Mediator of DNA damage checkpoint 1 10.3
CCDC36 10.3
ubiquitin specific peptidase 10 10.3
FBW6 10.3
WNK lysine deficient protein kinase 2 10.3
NYD-SP28 10.3
downstream neighbor of SON 10.3
PLEKHO1 10.3
ZNF506 10.3
FBXO46 10.3
SMUG1 protein 10.3
CCDC15 10.3
minichromosome maintenance 9 10.3
transmembrane protein 66 10.3
HIST1H2AA 10.3
myosin-IXa 10.3
c6.1A 10.3
H2AV 10.3
WD repeat and FYVE domain containing 3 10.3
MAD2L1BP 10.3
Zinc finger protein 668 10.3
PLAC9 10.3
SACM1L 10.3
ATR-interacting protein 10.2
AT1B 10.2
CHK2 10.1
ATR interacting protein 10.0
KIAA0170 10.0
TEL1 10.0
CCDC6 protein 9.9
Chk2 9.9
MRE11A 9.9
A-T 9.9
NBS1 9.8
MDC1 9.8
BRIP1 9.8
CHEK2 9.7
Tumor suppressor p53-binding protein 1 9.7
Rap1 interacting factor 1 9.7
sentan 9.7
POTEA 9.7
hRad50 9.7
Ribosomal protein S27 9.7
VSTM2B 9.7
SLC16A4 9.7
FLJ23560 9.7
mitogen-activated protein kinase kinase kinase 9 9.7
p8MTCP1 9.7
MTCP-1 9.7
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Disease
ATM 11.3
ATLD 10.8
AOA2 9.4
Progressive cerebellar ataxia 9.3
Environmental Cancer 9.3
Iminoglycinuria 9.3
SCAE 9.3
pediatric anaplastic astrocytoma 8.9
Seckel syndrome 8.7
Polymorphic PTLD 8.7
SCAN1 8.5
T Cell Leukemia 8.5
C cell tumor 8.5
Bladder hypertrophy 8.5
IOSCA 8.5
Hereditary Breast Cancer 8.4
IgG3 deficiency 8.2
Nezelof 8.1
FANCN 8.1
T-cell prolymphocytic leukemia 8.1
Specific antibody deficiency 8.1
FBH1 8.0
FANCI 8.0
NBS 7.9
SANDO 7.9
AT3 7.9
AT3 7.9
AT3 7.9
AT3 7.9
AT3 7.9
AT3 7.9
AT3 7.9
AT3 7.9
AT3 7.9
Acute left ventricular failure 7.8
Hereditary Breast and Ovarian Cancer 7.6
BRCAX 7.5
IgG4 deficiency 7.5
trisomy 8q 7.5
Mucocutaneous candidiasis 7.5
RS-SCID 7.5
congenital aplastic anemia 7.5
HND 7.4
TALS 7.4
IgG2 deficiency 7.4
Primordial dwarfism 7.4
temper tantrum 7.4
AGS2 7.4
trisomy 12q 7.4
Embryopathy 7.3
Combined immunodeficiency 7.2
MILS 7.2
AIMAH 7.2
MCPH1 7.2
BLM 7.1
FANCJ 7.1
telangiectasia 7.1
DKC 7.1
Pulmonary failure 7.1
IDDM4 7.1
DKC 7.1
FANCD1 7.1
hereditary ataxia 7.1
xeroderma pigmentosum 7.0
Primary immunodeficiency 7.0
Cockayne syndrome 6.9
FHA 6.9
Cerebellar degeneration 6.9
IgG1 deficiency 6.9
Fanconi syndrome 6.8
IgA deficiency 6.8
renin-dependent hypertension 6.8
mucinous adenocarcinoma of the colon 6.8
Multiple cancer 6.8
Xeroderma 6.7
ARP1 6.7
Xeroderma pigmentosum group C 6.6
WRN 6.6
XPV 6.6
13q deletion syndrome 6.6
more...
Symptom
Cri du chat 8.5
cerebellar ataxia 6.7
Pyramidal signs 6.7
Rest tremor 6.5
ataxia 5.2
staggering gait 5.1
impaired motor coordination 4.7
ataxic gait 4.5
Macula 4.4
Extrapyramidal symptoms 3.7
Cushingoid 3.5
Cushingoid 3.4
chorea 3.2
athetosis 3.2
clumsiness 3.2
incoordination 3.1
dystonia 3.0
myoclonus 2.9
CSR 2.8
abnormal gait 2.7
Involuntary Movement 2.6
dysarthria 2.5
blackout 2.4
neurological disability 2.4
Decreased activity 2.2
Anoxia 2.2
acute stress 2.1
cough 2.1
persistent cough 2.0
oliguria 2.0
hypertonia 2.0
hepatosplenomegaly 2.0
drooling 1.9
collapse 1.8
polydipsia 1.7
livedo 1.5
muscle cramps 1.4
functional recovery 1.4
Stiffness 1.3
polyuria 1.3
hyperoxia 1.2
Hudson 1.2
catatonia 1.1
hypoproteinemia 1.1
starvation 1.1
exhaustion 1.1
tremor 1.1
muscle stiffness 1.0
pallor 1.0
Mills 0.9
chronic constipation 0.9
fasciculation 0.9
Neuropathic pain 0.8
skin damage 0.7
dizziness 0.6
torticollis 0.6
memory loss 0.4
hepatomegaly 0.3
hypotonia 0.3
chronic cough 0.3
spasticity 0.2
thinning 0.1
bradykinesia 0.1
splenomegaly -0.0
masculinization -0.1
shortness of breath -0.1
erythema -0.1
asthenia -0.1
paraparesis -0.2
respiratory distress -0.2
cachexia -0.2
angina -0.3
bone pain -0.3
ophthalmoplegia -0.4
seizures -0.4
spasm -0.6
weakness -0.6
nausea -0.7
apathy -0.7
anesthesia -0.9
more...
Drug
Pyrroloquinoline Quinone 10.3
Atacand 9.9
Atacand 9.5
Angiotensin II 8.4
Micardis 8.4
7-Hydroxystaurosporine 8.1
Pemirolast 7.9
Irofulven 7.9
Losartan potassium 7.7
Valsartan 7.6
Fosinopril sodium 7.6
Olmesartan Medoxomil 7.4
Neocarzinostatin 7.3
Aliskiren 7.1
Idoxifene 7.1
Olmesartan 6.9
Olmesartan medoxomil 6.8
BLM 6.8
Bindarit 6.7
Forodesine 6.7
Aliskiren fumarate 6.7
Norleucine 6.4
Potassium canrenoate 6.4
Pixantrone 6.2
Aescin 6.2
CAZ 5.8
Cilazapril 5.7
Trabectedin 5.7
PBZ 5.5
Compound 18 5.4
Digibind 5.3
Lacidipine 5.3
ETA 5.2
Captopril 5.2
Clofarabine 5.1
Abamectin 5.0
Enalaprilat 5.0
Enalaprilat 5.0
Valproic Acid 4.7
AMK 4.7
caffeine 4.6
Compound 16 4.6
Bosentan 4.5
Bosentan 4.5
Ethyol 4.5
Etoposide 4.4
Trandolapril 4.4
Idebenone 4.3
Protamine sulfate 4.3
NAH 4.3
Axitinib 4.2
Febuxostat 4.1
Ramipril 4.1
Vinpocetine 4.1
Levosimendan 4.0
TEL 4.0
Lead acetate 4.0
NVP 3.9
Panitumumab 3.9
Irinotecan 3.9
Perindopril 3.9
Podophyllum 3.9
ROS 3.9
Tenofovir disoproxil fumarate 3.9
Atenolol 3.8
Ritanserin 3.8
Oxaliplatin 3.7
Mutagen 3.7
Indapamide 3.7
G418 3.7
Casodex 3.7
Abatacept 3.6
Pemetrexed 3.6
Tranilast 3.6
Flavopiridol 3.6
Photofrin 3.4
Cytidine 3.4
Fludarabine 3.4
RAL 3.3
Photofrin II 3.2
more...
Enzyme
STK11 8.1
neurolysin 7.0
renin 6.3
ACE 6.1
inositol polyphosphate 4-phosphatase 6.1
MT 1 6.0
thimet oligopeptidase 5.9
STK4 5.8
FabA 5.7
angiotensin-converting enzyme 2 5.6
PARP 5.6
aminopeptidase A 5.5
D-dopachrome tautomerase 5.2
chymase 5.2
polo-like kinase 1 5.1
AGT 5.1
topoisomerase 5.1
topoisomerase 5.1
choline dehydrogenase 5.0
protein L-isoaspartyl methyltransferase 5.0
benzoylformate decarboxylase 4.9
caspase-2 4.8
STK3 4.8
cdc2 4.8
caspase-2 4.8
CEP 4.7
polynucleotide kinase 4.7
NADPH oxidase 4.7
Lod 4.6
poly(ADP-ribose) glycohydrolase 4.6
endonuclease VII 4.6
NADPH oxidase 4.5
PTPase 4.4
separase 4.4
histone acetyltransferase 4.4
PI-PLC 4.4
inositol 3-kinase 4.4
oxytocinase 4.4
aryl-alcohol oxidase 4.4
AMPK 4.4
DSR 4.4
CTP synthase 4.3
phosphatidylinositol 3-kinase 4.3
GAR 4.3
ribonucleotide reductase 4.3
ribonucleotide reductase 4.2
threonine dehydrogenase 4.2
SRR 4.2
CEP 4.1
phosphoinositide 3-kinase 4.1
FADS 4.0
protein phosphatase 2A 4.0
dimethylarginine dimethylaminohydrolase 4.0
MAP 4.0
protein kinase 3.9
pseudouridine synthase 3.9
TOR 3.9
phospholipase C 3.9
phosphatidylinositol 4-kinase 3.9
3'-phosphatase 3.8
CYP46A1 3.8
tissue kallikrein 3.8
azoreductase 3.8
ACAT 3.8
sepiapterin reductase 3.7
glutamyl-tRNA synthetase 3.7
CLK1 3.7
HK2 3.7
GRK5 3.7
AMP-activated protein kinase 3.7
methionyl-tRNA synthetase 3.7
DNA ligase 3.6
DNA ligase 3.6
APC 3.6
HDR 3.6
acyl carrier protein synthase 3.6
mitogen-activated protein kinase 3.5
aminopeptidase P 3.5
endonuclease 3.5
phosphocholine cytidylyltransferase 3.5
more...
Compound
PD 123177 10.8
PD 123319 10.3
EXP 3174 10.2
2,3,3-trichloroacrylamide 9.7
4-chloro-1H-imidazole 9.7
Angiotensin IV 9.4
Losartan 9.3
7,7,7-triphenylheptanoic acid 8.9
BQ 485 8.9
C7H6N2O3 8.9
7,7,7-triphenylheptanoic acid 8.9
Candesartan 8.7
3H-imidazo[4,5-b]pyridine 8.7
3H-imidazo[4,5-b]pyridine 8.7
Hellebrigenin 8.7
Phosphoramide mustard 8.7
3H-imidazo[4,5-b]pyridine 8.7
7,7,7-triphenylheptanoic acid 8.7
Candesartan cilexetil 8.6
3H-imidazo[4,5-b]pyridine 8.6
Ang II 8.5
Mersalyl acid 8.5
Irbesartan 8.1
Angiotensin II 8.0
Coronafacic acid 7.9
Bufotalin 7.9
Eprosartan 7.9
Microcephalin 7.8
8-(diethylamino)octyl 3,4,5-trimethoxybenzoate 7.7
Ro 42-5892 7.6
Tricetin 7.6
Ronnel 7.6
[1,1'-biphenyl]-2-carboxylic acid 7.4
2,6-piperazinedione 7.4
Ovatodiolide 7.4
Neocarzinostatin 7.3
Telmisartan 7.3
Ailanthone 7.2
3-Acetylpyridine 7.1
Cryptolepine 7.0
Angiotensin III 7.0
Ailanthone 6.9
1,4-diamino-2-butanone 6.8
Camphorquinone 6.8
Amastatin 6.8
MnSe 6.7
TGR 6.7
Cucurbitacin B 6.6
Myristicin 6.6
Dithio 6.6
Rocaglamide 6.6
DTMA 6.5
dibenzo[def,p]chrysene 6.4
1H-benzo[de]isoquinoline-1,3(2H)-dione 6.4
Enalapril 6.3
C6F6 6.2
Trimethaphan 6.2
4-methoxybenzamide 6.2
XPA 6.2
XPA 6.2
Kaurenoic acid 6.2
HNa 6.2
Wortmannin 6.1
GW 9662 6.1
Bisdemethoxycurcumin 6.1
Escin 6.0
BLM 6.0
Tributyltin chloride 6.0
Escin 6.0
Methylxanthine 5.9
NS 1619 5.9
Mafosfamide 5.9
Nitroxoline 5.8
Angiotensin I 5.8
Sterigmatocystin 5.8
Theaflavin 5.8
Tempol 5.8
Hoe 5.7
Diepoxybutane 5.6
G 1 5.6
more...