Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0004135 (ATM)
 13,001 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ATM 5714
AT1 4545
angiotensin II 2486
p53 2085
Ang II 1578
ATR 1456
AT2 1404
A-T 1328
renin 1157
Mol 1106
Sep 864
H2AX 706
Chk1 687
BRCA1 678
DNA-dependent protein kinase 593
Chk2 551
histone 377
BRCA2 377
p21 376
ANG 349
ataxia telangiectasia mutated 312
ATM protein 302
ACE 301
angiotensin II receptor 298
53BP1 292
NBS1 267
angiotensin receptor 242
PARP 235
bradykinin 210
AT1R 210
CHK2 198
Rad50 196
angiotensinogen 190
caspase-3 189
telomeric 185
insulin 174
collagen 173
MRE11 170
CHEK2 169
CHK1 168
RAD51 164
MAPK 163
lymphoid 161
p38 159
PTEN 153
PALB2 145
mTOR 143
ERK1 141
phosphatase 137
ATP 130
PI3K 128
RAD50 128
ROS 116
cytokine 116
threonine 114
like kinase 112
MDC1 112
ubiquitin 111
AKT 111
Renin 110
ERK 110
Rad51 108
vasopressin 108
tyrosine kinase 108
cancer susceptibility 100
MDM2 97
cyclin 94
ATPase 92
JNK 91
phosphatidylinositol 3-kinase 91
nitric oxide synthase 90
CDKN2A 88
endonuclease 87
Bcl-2 87
AT1B 86
phosphorylating 84
RPA 83
proteasome 83
tumour suppressor 83
endothelin-1 82
APC 81
ACE2 80
TRF2 76
MLH1 76
BRIP1 75
Ku70 74
IgA 73
proximal tubule 72
PARP1 71
p16 70
MSH2 69
E2F1 69
TNF 68
calcium channel 67
Mdm2 67
Angiotensin-converting enzyme 66
XRCC1 65
proliferating cell nuclear antigen 65
EGFR 64
FANCD2 64
cyclin D1 63
helicase 63
RB1 62
KRAS 62
CtIP 61
BLM 61
PIK3CA 60
ADP 59
poly(ADP-ribose) polymerase 59
Bloom syndrome 58
MSH6 57
catalase 57
WAF1 57
CDK2 56
IL-6 56
Ku80 56
cyclin B1 55
c-fos 55
vascular endothelial growth factor 55
histone H3 55
superoxide dismutase 54
STK11 54
BAX 54
PKC 54
CD4 54
AMPK 53
fibronectin 53
nuclear protein 53
NOTCH1 53
histone deacetylase 53
CDH1 52
serine/threonine kinase 52
PARP-1 51
NBN 51
BRAF 50
BARD1 49
thymus 48
E3 ubiquitin ligase 48
STAT 47
MAP 47
GTP 47
caspase-9 47
cyclin E 46
ubiquitin ligase 46
MEK 46
AII 46
atrial natriuretic peptide 45
LIP 45
RNF8 45
alpha-fetoprotein 45
serine/threonine protein kinase 45
interferon 44
TopBP1 44
CDKN1A 44
c-Jun 44
mitogen-activated protein 44
RAD51C 43
CDK4 43
TGF-beta 43
XRCC4 43
more...
Disease
ATM 13001
cancer 2888
tumor 1374
hypertension 973
breast cancer 581
immunodeficiency 412
tumorigenesis 289
leukemia 264
heart failure 235
carcinogenesis 225
diabetes 212
NBS 191
BLM 175
chronic lymphocytic leukemia 174
lymphoma 169
ovarian cancer 167
genetic disorder 163
carcinoma 158
xeroderma pigmentosum 152
telangiectasia 148
anemia 138
prostate cancer 138
myocardial infarction 136
chronic lymphocytic leukemia 132
stroke 129
atherosclerosis 129
Fanconi 127
adenocarcinoma 117
ischemia 113
tumor growth 109
lung cancer 108
melanoma 103
Epstein 102
renal disease 98
proteinuria 95
tumor progression 90
cardiovascular disease 88
ventricular hypertrophy 88
colorectal cancer 87
WRN 86
preeclampsia 84
obesity 83
APC 83
essential hypertension 83
NAME 81
hepatocellular carcinoma 79
Fanconi syndrome 77
Alzheimer's disease 76
congestive heart failure 75
neuroblastoma 72
glioma 72
diabetic nephropathy 72
apraxia 72
MCF 72
squamous cell carcinoma 70
pancreatic cancer 69
Hodgkin's disease 66
mantle cell lymphoma 66
glioblastoma 65
premature aging 65
Cockayne syndrome 59
immune deficiency 58
pertussis 57
retinoblastoma 57
gastric cancer 56
colon cancer 56
SCID 55
acute myeloid leukemia 54
type 2 diabetes 53
metastases 52
Leukemia 50
Friedreich's ataxia 50
non-small cell lung cancer 48
renal failure 48
IgA deficiency 47
myocardial ischemia 45
glomerulosclerosis 45
ARF 45
skin cancer 44
multiple myeloma 42
trisomy 42
GSH 41
HIV 40
Down syndrome 40
acute lymphoblastic leukemia 40
Wiskott-Aldrich syndrome 40
depression 39
Parkinson's disease 39
Li-Fraumeni syndrome 38
B-cell lymphoma 38
Seckel syndrome 37
virus infection 37
Huntington's disease 33
amyotrophic lateral sclerosis 31
sarcoma 31
chronic renal failure 30
Blocking 30
B-cell chronic lymphocytic leukemia 30
SDS 29
metabolic syndrome 29
cervical cancer 28
herpes simplex 28
coronary artery disease 28
brain tumor 28
hyperglycemia 28
non-Hodgkin's lymphoma 27
glioblastoma multiforme 26
FHA 26
lung carcinoma 26
neoplastic transformation 26
mole 26
neuropathy 26
bladder cancer 25
Hippel 25
Burkitt's lymphoma 25
plaque 24
chronic myeloid leukemia 24
mental retardation 24
B-cell lymphomas 24
osteosarcoma 23
mental retardation 23
tuberous sclerosis 23
epithelial ovarian cancer 23
T-cell prolymphocytic leukemia 23
infertility 23
cold 23
Lynch syndrome 22
lymphopenia 22
PML 22
T-cell acute lymphoblastic leukemia 21
renal cell carcinoma 21
PHA 21
SARS 21
adenoma 21
mole 21
progeria 21
uterus 21
ABL 20
MAS 20
coronary heart disease 20
lung disease 20
AT3 19
microalbuminuria 19
AT3 19
AT3 19
vascular disease 19
AT3 19
AT3 19
hypogammaglobulinemia 19
AT3 19
lymphoproliferative disorders 19
AT3 19
AT3 19
FANCI 19
dementia 19
AT3 19
acute promyelocytic leukemia 18
myelodysplastic syndrome 18
Glioblastoma 18
cerebral ischemia 18
more...
Symptom
ataxia 233
cerebellar ataxia 154
cough 41
collapse 40
dystonia 28
seizures 24
anesthesia 24
starvation 22
pain 17
tremor 16
functional recovery 14
myoclonus 13
exhaustion 12
headache 11
fatigue 11
weakness 10
diarrhea 9
dysarthria 9
chorea 8
acute stress 8
angina 7
respiratory distress 7
hepatosplenomegaly 7
dizziness 6
nausea 6
incoordination 6
erythema 5
hyperoxia 5
thinning 5
vomiting 5
ataxic gait 5
overweight 4
splenomegaly 4
anorexia 3
polyuria 3
acidity 3
abnormal gait 3
hypotonia 3
hepatomegaly 3
oliguria 3
polydipsia 3
spasticity 3
CSR 2
Rest tremor 2
syncope 2
shortness of breath 2
sleepiness 2
pallor 2
dyspnea 2
memory loss 2
clumsiness 2
discomfort 2
cachexia 2
impaired motor coordination 2
hypothermia 2
discomfort 2
spasm 2
hypertonia 2
neurological disability 2
Cri du chat 1
Decreased activity 1
constipation 1
chronic cough 1
Cushingoid 1
drooling 1
Anoxia 1
tinnitus 1
Stiffness 1
torticollis 1
regurgitation 1
arthralgia 1
Ill 1
Involuntary Movement 1
bradykinesia 1
asthenia 1
fasciculation 1
staggering gait 1
blackout 1
Mills 1
analgesia 1
Hudson 1
athetosis 1
Pyramidal signs 1
Extrapyramidal symptoms 1
myalgia 1
Macula 1
hypercapnia 1
masculinization 1
persistent cough 1
livedo 1
bone pain 1
back pain 1
abdominal pain 1
lethargy 1
Cushingoid 1
muscle cramps 1
Neuropathic pain 1
skin damage 1
hypoproteinemia 1
catatonia 1
chronic constipation 1
ENT 1
paraparesis 1
muscle stiffness 1
ophthalmoplegia 1
chest pain 1
apathy 1
Drug
Angiotensin II 698
caffeine 210
Cardiovasc 174
ROS 116
lysine 89
BLM 61
MAP 49
Dermatol 48
ETA 43
Valsartan 37
Captopril 34
Mutagen 32
IL-2 17
ascorbate 17
Nephron 16
Aliskiren 15
NADH 14
IFN-gamma 14
Indomethacin 13
vitamin E 12
G418 12
CSF 10
Olmesartan 10
Asn 10
nitroglycerin 10
Nephron 10
Etoposide 10
Gel 10
CTX 10
ICI 10
MOF 10
MRC 8
DNase I 8
CPT-11 7
Dial 7
Neocarzinostatin 7
ETS 7
Ethanol 7
EE2 6
NVP 6
Heme 6
Alanine 5
Losartan potassium 5
Adriamycin 5
Atenolol 5
Nitric Oxide 5
TEL 5
Oxaliplatin 5
Imatinib 5
IL-1ra 5
Glutathione 5
Irinotecan 5
Monit 4
BH4 4
Olmesartan medoxomil 4
Photofrin 4
Bosentan 4
niacin 4
Bosentan 4
CTX 4
CAZ 4
CTX 4
MDS 4
ADR 4
ABC 4
Micardis 3
TTC 3
Parkin 3
Trabectedin 3
Fructose 3
Atropine 3
Rosiglitazone 3
Leaf 3
Sodium nitroprusside 3
Spectrum 3
Irofulven 3
Arsenic trioxide 3
TAT 3
Spectrum 3
Lovastatin 3
Amiloride 3
PTC 3
Cilazapril 3
EPA 3
DEX 3
Parkin 3
Ramipril 3
VCR 2
TAK 2
TiO2 2
Fludarabine 2
Levosimendan 2
Ouabain 2
Enalaprilat 2
Albumin 2
Clofarabine 2
Atacand 2
Atacand 2
Amiloride 2
Lacidipine 2
EPI 2
Methylene blue 2
Abamectin 2
CAM 2
IFN-beta 2
Compound 18 2
PTH 2
Enalaprilat 2
Paraffin 2
Growth hormone 2
Hypaque 2
Perindopril 2
Digitalis 2
TAC 2
CFS 2
NBT 2
Pemetrexed 2
GEO 2
Forskolin 2
VCR 2
Asthma 2
Growth hormone 2
Gleevec 2
ENT 2
Diphenhydramine 1
Idebenone 1
CDP 1
Olmesartan Medoxomil 1
PMPA 1
Dasatinib 1
Nebivolol 1
NH3 1
Capsicum 1
Doxycycline 1
Pixantrone 1
Trandolapril 1
Forodesine 1
Gabapentin 1
Casodex 1
Ipilimumab 1
DMAP 1
Zoledronic acid 1
Potassium canrenoate 1
Glutamic acid 1
Retinoic acid 1
Lead acetate 1
AraC 1
Axitinib 1
Diurnal 1
Dihydro 1
Sorafenib 1
Vinpocetine 1
Valproic Acid 1
Podophyllum 1
Hydrochlorothiazide 1
balanced salt solution 1
PCP 1
Ethyol 1
Indapamide 1
-deoxyadenosine 1
more...
Enzyme
renin 1157
ACE 514
protein kinase 512
mitogen-activated protein kinase 454
ERK 345
PARP 277
protein kinase C 212
focal adhesion kinase 138
topoisomerase 138
caspase-3 133
topoisomerase 129
NADPH oxidase 117
phospholipase C 111
ATPase 99
cdc2 96
NADPH oxidase 93
phosphatidylinositol 3-kinase 91
endonuclease 87
proteasome 83
APC 83
superoxide dismutase 75
MEK 73
AMP-activated protein kinase 68
RNA polymerase 68
calcineurin 64
catalase 64
luciferase 60
STK11 54
AMPK 54
AMPK 53
NO synthase 52
MAP 47
DNA polymerase 46
phosphoinositide 3-kinase 41
reverse transcriptase 38
caspase-9 34
CD10 33
collagenase 26
kallikrein 25
glutathione S-transferase 24
ribonucleotide reductase 24
histone acetyltransferase 24
tyrosine hydroxylase 23
ribonucleotide reductase 22
polo-like kinase 1 22
IKK 21
angiotensin-converting enzyme 2 21
caspase-8 20
phosphodiesterase 20
chymase 20
phospholipase A2 20
protein phosphatase 2A 20
transcriptase 19
guanylate cyclase 19
RNase 19
adenylate cyclase 19
RNase 19
peroxidase 16
DNA methyltransferase 16
glutathione peroxidase 15
beta-galactosidase 15
DNA ligase 14
DNA ligase 14
NOS 13
lactate dehydrogenase 13
thrombin 13
alkaline phosphatase 11
AGT 11
alanine aminotransferase 11
thymidine kinase 11
CPT 10
CPT 10
glucose-6-phosphate dehydrogenase 10
phospholipase D 10
GSK 10
xanthine oxidase 10
CPT 10
caspase-2 9
isocitrate dehydrogenase 9
isocitrate dehydrogenase 9
complex I 9
trypsin 9
PTPase 9
caspase-2 9
TOR 9
ACS 8
tissue plasminogen activator 8
CEP 8
creatine kinase 8
aminopeptidase A 8
hypoxanthine-guanine phosphoribosyltransferase 8
PKG 8
DNase 8
glyceraldehyde-3-phosphate dehydrogenase 8
CEP 8
MEKK1 8
ornithine decarboxylase 7
polynucleotide kinase 7
PRA 7
tissue kallikrein 7
NQO1 7
dihydrofolate reductase 6
MMP 6
acetylcholinesterase 6
CD13 6
chloramphenicol acetyltransferase 6
GRK5 6
P-glycoprotein 6
PDK1 6
lipoprotein lipase 6
neurolysin 5
thimet oligopeptidase 5
cathepsin D 5
MAT 5
heme oxygenase 5
cathepsin B 5
CAD 5
cytochrome oxidase 5
ribonuclease 5
CaMKII 5
aspartate aminotransferase 5
CAD 5
CAD 5
ribonuclease 5
MAT 5
PI-PLC 5
thromboplastin 5
glyceraldehyde-3-phosphate dehydrogenase 5
lipase 4
STR 4
MMP-3 4
glutathione reductase 4
cholesterol acyltransferase 4
caspase-1 4
micrococcal nuclease 4
ADP-ribosyltransferase 4
ADP-ribosyltransferase 4
purine nucleoside phosphorylase 4
RNase H 4
lipoxygenase 4
pyruvate kinase 4
phosphorylase 4
peroxiredoxin 4
phosphatidylinositol 4-kinase 4
thymidylate synthase 4
matrix metalloproteinase 2 3
deoxycytidine kinase 3
PNGase F 3
HK2 3
plasmin 3
transglutaminase 3
prostate-specific antigen 3
methylenetetrahydrofolate reductase 3
cathepsin G 3
gamma-glutamyl transpeptidase 3
LPL 3
separase 3
alcohol dehydrogenase 3
fumarase 3
glyceraldehyde-3-phosphate dehydrogenase 3
more...
Compound
DNA 5698
Ang II 1006
Angiotensin II 919
Dec 914
oxygen 528
Clin 515
sodium 417
calcium 412
Losartan 386
acetate 377
serine 361
aldosterone 332
water 298
nitric oxide 246
caffeine 210
threonine 199
tyrosine 194
arginine 185
salt 184
glucose 167
PD 123319 154
ATP 131
phosphate 124
lysine 119
Cardiol 115
hydrogen 99
cAMP 97
potassium 97
alanine 96
BLM 73
TNF 68
Candesartan 68
cysteine 68
urea 64
cGMP 63
ADP 62
PD 123177 60
noradrenaline 60
ADP 59
ADP 59
leucine 56
pyridine 53
glutamate 51
creatinine 51
N-acetylcysteine 49
COS 49
GTP 47
methionine 47
MAP 47
MDA 46
GSH 45
GSH 45
H2O2 44
ADP-ribose 44
ETA 43
methyl methanesulfonate 42
nitrogen 42
MTT 41
Phe 41
MEK 39
Asp 38
pyrimidine 37
pyrimidine 37
ethanol 36
prostacyclin 36
iron 36
NADPH 35
Serine 35
AMP 35
His 34
NADPH 34
ACTH 33
Wortmannin 33
Telmisartan 32
glutamine 31
Irbesartan 31
Ile 31
XPA 30
XPA 30
EXP 3174 30
DDP 28
Enalapril 28
SDS 28
proline 27
iodine 27
Histone 26
Adriamycin 26
ADR 25
NAD 25
NH2 23
NBS 22
nitrate 21
1,1'-biphenyl 21
NAD 21
PGE2 20
zinc 20
Insulin 20
CO2 20
sulfate 20
chromium 18
TGR 18
5-HT 18
Candesartan cilexetil 18
bromide 18
8-OHdG 18
pyrene 16
Bradykinin 16
boron 16
Panam 16
GABA 16
Gly 16
Angiotensin IV 15
carbonate 15
GABA 15
Salt 15
Genistein 15
PMA 15
BCR 15
dUTP 14
Tempol 14
PAR 14
VP-16 14
silver 14
Estrogen 14
Neuronal 14
NADH 14
Phosphatidylinositol 14
ABL 13
tryptophan 13
Hoe 13
phosphoserine 13
nicotinamide 13
Pac 13
tryptophan 12
DMSO 12
ATC 12
vitamin D 12
galactose 12
Estrogen 12
tryptophan 12
tryptophan 12
manganese 12
PMA 12
Curcumin 12
ATC 12
Metformin 11
CPT 11
ACh 11
retinoic acid 11
methane 11
Adrenal 11
Metformin 11
Indomethacin 11
ATA 11
ammonium 10
superoxide radical 10
aspartic acid 10
pentose 10
Rapamycin 10
pentose 10
more...