Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0004135 (
ATM
)
13,001
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Programmed cell death 2
(
PDCD2
) is a highly conserved nuclear protein, and aberrant
PDCD2
expression alters cell apoptosis. The present study aimed to investigate
PDCD2
expression in gastric cancer. Tissue specimens from 34 gastric cancer patients were collected for analysis of
PDCD2
expression using immunohistochemistry, western blotting and qRT-PCR. Gastric cancer cell lines (a p53-mutated MKN28 line and a wild-type p53 MKN45 line) were used to assess the effects of
PDCD2
overexpression. p53-/- nude mice were used to investigate the effect of
PDCD2
on ultraviolet B (UVB)-induced skin carcinogenesis. The data showed that
PDCD2
expression was reduced in gastric cancer tissue specimens, and loss of
PDCD2
expression was associated with the poor survival of patients.
PDCD2
expression induced gastric cancer cell growth arrest at the early S phase of the cell cycle and apoptosis. The antitumor effects of
PDCD2
expression were dependent on p53 expression in gastric cancer cells. Moreover,
PDCD2
expression inhibited activity of the
ATM
/Chk1/2/p53 signaling pathway. In addition,
PDCD2
expression suppressed UVB-induced skin carcinogenesis in p53+/+ nude mice, but not in p53-/- mice. The data from the present study demonstrated that loss of
PDCD2
expression could contribute to gastric cancer development and progression and that
PDCD2
-induced gastric cancer cell growth arrest at the early S phase of the cell cycle and apoptosis are p53-dependent.
...
PMID:Programmed cell death 2 protein induces gastric cancer cell growth arrest at the early S phase of the cell cycle and apoptosis in a p53-dependent manner. 2533 10
