Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004135 (ATM)
 13,001 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is currently unclear whether activation of the AT1 receptor by agonists involves conformational selection or induction. We evaluated the pharmacological properties of wild type and N111G CAM human AT1 receptors stably expressed in HEK293 cells. Although [Sar1]-Ang II and Ang IV were full agonists at both receptors, the potency of Ang IV was 280-fold lower at the wild type receptor. [Sar1, Ile8]-Ang II was only a full agonist at the N111G CAM AT1 receptor. [Sar1]-Ang II and [Sar1, Ile8]-Ang II displayed similar high affinity binding to both receptors. In contrast, Ang IV displayed low affinity binding to the wild type and high affinity binding to the N111G CAM AT1 receptor. Based on these observations we provide strong evidence that conformational induction is the key process for activation of the AT1 receptor. Only by the creation of CAMs can conformational selection be envisaged to take place.
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PMID:Conformational induction is the key process for activation of the AT1 receptor. 1634 47

Cancer of the cervix is the most important female malignancy in the developing world and is mainly treated by radiotherapy. Treatment results may improve following the application of evolving laboratory techniques. Measurement of tumour radiosensitivity already seems possible using the Courtney-Mills assay. Unfortunately this requires about 5 weeks to produce clinically useful data. More rapid techniques such as the CAM assay and tests for DNA double strand breaks as predictors of radiosensitivity are being evaluated. Radiation dosage is limited by the probability of late normal tissue damage. The identification of individuals who may suffer excessive damage such as ataxia-telangiectasia hetorozygotes may enable higher doses to be given to the 'normal' majority. Cell kinetic studies have shown that repopulation is an important source of radioresistance and some tumours may respond better to accelerated hyperfractionated radiation schedules. Repair, proliferation capacity and radioresistance are all factors under genetic control. The search for the genes responsible remains a high priority.
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PMID:How the laboratory can help the clinician improve cure rates in invasive cervical-cancer. 2158 48