Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004134 (ataxia)
 15,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report here the characterization of an asymmetric ataxia syndrome (head tilt and circling, with death in the most severe cases) demonstrated by profoundly immunodeficient mice housed at the Institut Curie SPF facility. The immune system of the affected mice had been genetically modified so that they were deficient in both B and T cells. Extensive bacteriologic, parasitic, serologic, and histopathologic analysis of the affected animals and their healthy controls led us to identify Ralstonia pickettii as the causative agent of the ataxic syndrome. The outbreak was managed through a test-and-cull process. Even though they also carried Ralstonia pickettii, immunocompetent mice that were kept in the same facility, did not show any of the signs that were expressed by their immunodeficient counterparts. This case highlights the difficulty of maintaining immunocompetent and immunodeficient mice in the same microbiologic unit and the importance of enlarging the spectrum of health monitoring to opportunistic agents when investigating clinical cases in populations of immunocompromised rodents.
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PMID:Ralstonia pickettii-induced ataxia in immunodeficient mice. 1938 12

Recently, excessive losses from Marek's disease (MD) have been noted in adult laying flocks over the age of 40 weeks. We defined these late outbreaks in adult chickens as "late MD", and experimentally reproduced the disease in adult SPF P2 line (50-week-old) or commercial line (74-week-old) chickens inoculated with a virulent strain of Marek's disease virus (MDV). Commercial line chickens were given MDV vaccines (HVT and CVI 988) at hatch. The occurrence of MD was evaluated periodically by the evidence of neurologic signs such as paralysis, torticollis, ataxia, and/or nervous tics, as well as histopathological examination. In P2 line chickens, neurologic signs and MD lymphoma were observed from day 21 onward, and they tended to increase in a time-dependent manner. Meanwhile, in commercial line chickens, only one chicken exhibited MD lymphoma on day 70 post inoculation, but its pathogenesis was questionable. No regression of MD lymphoma was noted in either case. The lesions in the visceral organs, thymus, peripheral nerves, and feather pulps of P2 line chickens were characterized by proliferation of variably sized lymphoid cells. In the feather follicle epithelium, numerous inclusion bodies were noted on day 21 post-inoculation, which tended to decrease afterwards. The morphological findings obtained resembled late MD in field cases. In conclusion, our results demonstrate that adult SPF P2 line chickens are susceptible to virulent MDV, and would be useful for investigation of late MD.
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PMID:Late Marek's disease in adult chickens inoculated with virulent Marek's disease virus. 2065 65