Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004134 (ataxia)
 15,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We examined the effects of chinoform (CF) on the spinal reflexes and the descending influences on the spinal reflexes from the locus coeruleus (LC) and the nucleus raphe magnus (NRM) in rats. The spinal reflex potential was recorded from the L5 ventral root following stimulation of the L5 dorsal root, and the effects of electrical stimulation of the LC and the NRM were tested in anesthetized rats. CF was suspended in Tween 80 and administered for two days (400 mg/kg, i. p./day) before the measurement of the spinal reflexes. In all rats treated with CF, death or motor incoordinations such as abnormal gait and hindlimb ataxia were observed. However, the control and CF-treated groups are not different in the amplitude and shape of the reflexes and in the influences of the LC and the NRM on the reflexes from the LC and the NRM. These results suggest that segmental spinal reflexes and descending influences from the LC and the NRM are not affected in rats suffered from motor incoordination by acute CF.
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PMID:Spinal reflexes in chinoform-administered rats. 294 92

Polyoxyethylene (20) sorbitan monooleate (polysorbate 80, Tween 80), a surfactant, has been widely used as a solvent for pharmacological experiments. In the present study, polysorbate 80 was found to have toxicity of a low order in both the mice and rats when given by i.p. and p.o. routes. It produced mild to moderate depression of the central nervous system with a marked reduction in locomotor activity and rectal temperature, exhibited ataxia and paralytic activity and potentiated the pentobarbital sleeping time. On intravenous administration in dogs, it had a dose-dependent hypotensive effect. Polysorbate 80 did not have a direct stimulant or relaxant effect on either guinea pig ileum or rat uterus, however, it antagonised the contractions induced by acetylcholine, histamine, barium, 5-hydroxytryptamine and carbachol in a dose-dependent manner. A direct relaxant effect was observed on rabbit jejunum. A dose-dependent myocardial depressant effect was observed on guinea pig and rabbit paired atrial preparations. On the electrically-driven guinea pig left atrial preparation, polysorbate 80 exhibited a dose-dependent negative inotropic action. Polysorbate 80 did not induce diuresis in rats upto a dose of 2.5 ml/kg. The results of the present study indicate that polysorbate 80 can neither be used as a solvent for isolated tissue experiments nor when considered for intravenous administration. However, polysorbate 80 can be employed safely as a vehicle for neuropsychopharmacological experiments in doses not exceeding 1 ml/kg.
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PMID:Polysorbate 80: a pharmacological study. 402 3