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Query: UMLS:C0004134 (ataxia)
 15,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Experimental and theoretical research into cerebellar function has begun to converge toward understanding the cerebellum as a "controller" in the engineering sense. The purpose of a controller is to convert high-level intent commands and information describing the current state of a system into low-level control signals suitable for maintaining or changing system behavior. The cerebellar subsystem appears to play this role for parts of the body and other parts of the brain. As with engineering controllers, fundamental functions include stabilization at a fixed posture or state, adjustment of movement or transition amplitude, facilitation of movement/transition speed and crispness of launch and braking, improvement of resistance to disturbances, coordination of control across multiple degrees of freedom, and assistance with estimation and/or prediction of current and future system states. As with adaptive engineering controllers, the cerebellar subsystem also readily tunes itself over time. At a more detailed level, many of the specific actions of cerebellar circuits can be understood in terms of proportional (P), integrator-like (I), and differentiator-like (D) signal processing which are fundamental components of many engineering control systems. This chapter presents an integrated, mechanistic view of ataxia, tremor, and several cerebellar oculomotor signs in terms of PID control and the neural centers that appear to subserve these functions. It also suggests the manner in which impairments in motor learning, perception, and cognition that are associated with cerebellar dysfunction may be viewed from a similar perspective.
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PMID:Physiology of clinical dysfunction of the cerebellum. 2182 80

Human generates very slow (<1 Hz) body sway during standing, and the behavior of this sway is known to be changed characteristically depending on the neural ataxia. In order to investigate the sway mechanism and mechanism of neural ataxia through this sway behavior, the present research proposes an experimental environment of rats under bipedal standing. By the experiment, we succeeded the measurement of six intact rats standing for over 200 seconds without postural supports. Moreover, by comparing measured center of pressure (COP) and that of system model with nonlinear PID control model which is proposed as human standing model, control parameters of rats were numerically evaluated. Evaluated control parameters of rats were close to those of human, i.e., control strategy was considered to be comparable between rats and human.
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PMID:Measuring body sway of bipedally standing rat and quantitative evaluation of its postural control. 2673 90