Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004134 (ataxia)
 15,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Systemic (ip) injection of dizocilpine maleate (DM, 0.1 and 0.5 mg.kg-1) increased the levels of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid but did not bring about any noticeable change in the dopamine (DA) level in the striatum and limbic area. DM also increased the levels of norepinephrine in the limbic area and 5-hydroxyindoleacetic acid in the hippocampus. Amphetamine increased DA level and reduced DOPAC level in the striatum and limbic area. The behavioral manifestations revealed that DM predominantly evoked circling behavior and ataxia. The results indicate that the mechanism of the behavioral effect of DM may be different from that of amphetamine.
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PMID:Effect of dizocilpine maleate on monoamines and their metabolites in rat brain. 144 99

GDEE, an antagonist of the AA2 or quisqualic acid category of excitatory amino acid receptor, decreases behavioral activity and locomotor stimulation induced by cocaine and amphetamine when locally injected into the nucleus accumbens. The present experiment was intended to examine the effects of systemic GDEE and other excitatory amino acid antagonists on stimulant-induced locomotor activity. GDEE markedly attenuated the stimulant effect of amphetamine, and partially blocked the effects of phencyclidine (PCP). Apomorphine-induced cage climbing behavior was partially decreased by lower dosages of GDEE, but was almost completely blocked by the highest dosage tested. Amphetamine-induced stimulation of locomotor activity was not decreased by any of the other excitatory amino acid antagonists that were tested, including MK-801, 2-amino-7-phosphonoheptanoic acid (APH), or CNQX. APH decreased stereotypy only at a high dosage (250 mg/kg), which also produces ataxia. Several other compounds, including L-glutamic acid gamma ethyl ester (GMEE), L-glutamic acid, glycine, and L-glutamine did not block amphetamine-induced stimulation in molar dosages equivalent to the highest dosage of GDEE (8 mmol/kg). It is concluded that the AA2 excitatory amino acid receptor is important in the expression of activating effects of stimulant drugs.
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PMID:A possible role of AA2 excitatory amino acid receptors in the expression of stimulant drug effects. 197 5