Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004134 (ataxia)
 15,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 1988, the specific benzodiazepine antagonist, flumazenil (Anexate Roche), was introduced in clinical practice in Czechoslovakia for analgesia. A pilot study was initiated to establish whether .1 mg of flumazenil iv was capable of accelerating the psychic recovery of women after abortion. 30 healthy women aged 17-25 received a combination of .1 mg/kg-1 diazepam iv together with .88 mg/kg-1 ketamine iv. Another group of 10 women of the same age range were given .05 mg/kg-1 of midazolam iv. Flumazenil, in a dose of .1 mg iv, was administered to the women following the completion of the procedure, i.e., about 5-7 minutes after giving benzodiazepine. The effect of flumazenil became apparent 30 seconds after iv administration. The hypnotic-sedative effect of benzodiazepine set in after 30-60 seconds, and its biological half-life was 50-60 minutes. After administration of midazolam, an especially strong sedative effect was produced for operative intervention. The psychic effects of ketamine lasted only a little while and no occurrence of psychomimetic symptoms were observed as determined by an orientation test of place, time, and space. Retrograde amnesia was complete during the procedure. Partial amnesia occurred after administration of flumazenil. The lowest flumazenil doses antagonized only the hypnotic and sedative effects of benzodiazepine but did not influence the anxiolytic and amnestic effects. Systolic pressure increased by 10 torr: the pulse rate increased on the average from 74.4 - 84.8 beats/minute. Mild ataxia occurred in women who attempted to get out of bed, but 60 minutes after completion of the procedure, the patients were able to walk without ataxia. It was clearly demonstrated that the sedative-hypnotic effects of benzodiazepine can be subdued after abortion, shortening the period required for the recovery of the patient.
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PMID:[Initial experience with flumazenil (Anexate Roche) for abortion]. 250 17