Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004134 (ataxia)
 15,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

L-asparaginase was used to treat a 4-year-old Holstein cow with lymphosarcoma that involved the spinal cord, subiliac lymph nodes, and retrobulbar space. The cow received 60,000 IU of L-asparaginase IV for a total of 4 treatments. After each treatment, the cow's condition improved, characterized by decreased weakness, decreased ataxia, a reduction in size of the left subiliac lymph node, and decreased exophthalmos. Side effects were not observed. The cow was kept alive for 57 days. This treatment offers a way of salvaging the genetic potential of valuable cows and bulls.
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PMID:Treatment of bovine lymphosarcoma with L-asparaginase. 339 57

Described here are the clinical features and results of treatment in a 10-year-old Saudi Arabian girl with primary T-cell lymphoma of the central nervous system. At presentation the patient had nystagmus and ataxia. The diagnosis was established by tissue biopsy obtained from the cerebellum. Therapy included cranio-spinal irradiation and combination chemotherapy of a systemic high dose of methotrexate, cytosine, arabinoside, and L-asparaginase. Remission was obtained easily but was interrupted by a local intracranial relapse 57 months after diagnosis (37 months after cessation of therapy; at present the patient is still alive and receiving palliative treatment). This report is warranted because of the rarity of this condition in children.
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PMID:Primary T-cell lymphoma of the brain in children: a case report and literature review. 1084 34