Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004134 (ataxia)
 15,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The objectives of this trial were to determine the ability of atipamezole, 4-aminopyridine and yohimbine to reverse the anaesthetic effects of a combination of medetomidine and ketamine in cats. Forty healthy cats were anaesthetised with 80 micrograms/kg medetomidine combined with 5 mg/kg ketamine. Thirty minutes later atipamezole (200 or 500 micrograms/kg), 4-aminopyridine (500 or 1000 micrograms/kg) or yohimbine (250 or 500 micrograms/kg) were injected intramuscularly. The doses of antagonists were randomised, so that each dose was administered to five cats, and 10 cats were injected only with physiological saline. Atipamezole clearly reversed the anaesthesia and bradycardia induced by medetomidine and ketamine. The mean (+/- sd) arousal times were 28 (+/- 4.7), 5.8 (+/- 1.8) and 7 (+/- 2.1) minutes in the placebo group, and the groups receiving 200 and 500 micrograms/kg atipamezole, respectively. The heart rates of the cats receiving 200 micrograms/kg atipamezole rapidly returned to values close to the initial ones, but 15 minutes after the injection of 500 micrograms/kg atipamezole a significant tachycardia was observed. All the cats showed moderate signs of ataxia during the recovery period. A dose of 500 micrograms/kg yohimbine also clearly reversed the anaesthetic effects of medetomidine/ketamine but 250 micrograms/kg was not effective. The dose of 500 micrograms/kg allowed a smooth recovery with no particular side effects except for some signs of incomplete antagonism of the ketamine effects, ie, ataxia and muscular incoordination. With 4-aminopyridine there were no statistically significant effects on the recovery, or the heart and respiratory rates of the cats anaesthetised with medetomidine/ketamine.
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PMID:Antagonistic activities of atipamezole, 4-aminopyridine and yohimbine against medetomidine/ketamine-induced anaesthesia in cats. 200 54

Sickness occurred in 3 of 4 horses within 24 h of being sprayed with an 0.025% w/v aqueous suspension of amitraz. The latter consisted of a portion of an amitraz aqueous suspension made up some 3 weeks previously, to which some freshly prepared spray fluid had been added. It seemed likely that the amitraz in the older solution had broken down to the highly toxic N-3, 5- dimethylphenyl N-methyl formamadine derivative and that this was in fact the main cause of the untoward effects observed. The horses displayed typical clinical signs of tranquillisation, depression, ataxia, muscular incoordination and impaction colic lasting up to 6 days. Subcutaneous oedema of the face occurred in one horse. The syndrome was accompanied by mild dehydration and acidosis. All horses survived after persistent symptomatic treatment including the giving of intravenous fluids, enemas, analgesics every 3 h, multiple doses of paraffin oil per os and dexamethasone intravenously. Following the eventual relief of constipation the horses scoured profusely for 24 h before their condition returned to normal.
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PMID:Illness in horses following spraying with amitraz. 650 68

Two female rhesus macaques (Macaca mulatta) and one female pigtailed macaque (M. nemestrina) developed acute neurological signs including ataxia, muscular incoordination, and seizures. Light microscopy showed Cowdry Type A intranuclear inclusion bodies in astrocytes and neurons of the cerebral cortex and Purkinje's cells of the cerebellum. Many cells also had intracytoplasmic inclusion bodies. Electron microscopy identified paramyxoviral nucleocapsids in the intranuclear and intracytoplasmic inclusions in two monkeys. We believe these monkeys had measles encephalitis because measles virus is the only paramyxovirus known to cause inclusion bodies in macaques and because the lesions in these monkeys resembled measles encephalitis in man.
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PMID:Spontaneous paramyxoviral encephalitis in nonhuman primates (Macaca mulatta and M. nemestrina). 707 86