Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004134 (ataxia)
 15,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The hypnotic effect and tolerance of quazepam (Sch 16134) 15 and 30 mg, flunitrazepam 1 and 2 mg and placebo were evaluated in a one-night, randomized, double-blind, parallel group study of 100 hospitalized patients, who were to undergo a planned operation on the following day. All active drugs were rated as superior to placebo by the physician. Subjectively, quazepam 30 mg and flunitrazepam 1 and 2 mg were superior to placebo. Hangover effects were not distinguishable from placebo. Vigilance and ataxia tests were not altered by any of the drugs.
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PMID:Comparison of quazepam, flunitrazepam and placebo as single-dose hypnotics before surgery. 613 25

From the clinical point of view, the nervous system effects of alcohol are the most important when work-related problems are considered. Alcohol is a primary, descending, central nervous system depressant that causes a familiar dose-dependent progression of acute intoxication from euphoria to ataxia, stupor, and ultimately coma. Chronic effects of alcohol on the nervous system are more difficult to diagnose. Particularly an insidiously developing alcoholic psychoorganic syndrome is a very difficult problem in occupational health. The interactions of low-level, chronic exposure to solvents and heavy drinking are interesting but, unfortunately, poorly understood. Withdrawal phenomena ranging from common hangover to tremulousness, cerebral convulsions, and delirium can also severely disturb normal worklife. The multitude of factors which regulate drinking behavior among the working population provides a challenge for investigators in the field of occupational health. More research should be focused on alcohol diseases and their effects on work, the effects of work on alcohol consumption, and the interactions of alcohol and compounds present in the work environment. The first step towards these problems is the development of valid methods for the early detection of heavy drinkers among the working population.
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PMID:Alcohol, work and the nervous system. 639 13

Congeners are minor compounds other than ethanol that occur naturally in alcohol beverages as a result of distilling and fermenting processes. While ethanol itself is the main source of hangover (subjective distress) and other residual effects of alcohol (cognitive and behavioral), the role of the congeners is of interest due to the potential toxicity of many of them despite their minute quantities. Survey studies, while comparing beer to liquor to wine, have generally not addressed beverage effects that clearly differ in congener content. The few experimental studies indicate that the highest congener beverage (bourbon) results in more severe hangover ratings than does the beverage with essentially no congeners (vodka), although ethanol effects per se had a considerably stronger effect on hangover than did congener content. Safety-sensitive performance that was affected by alcohol intoxication the previous night (vigilance with reaction time; ataxia) was not differentially affected by bourbon versus vodka. The paucity of studies indicates more work is needed in order to have confidence in these results.
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PMID:The role of beverage congeners in hangover and other residual effects of alcohol intoxication: a review. 2071 91