Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004134 (ataxia)
 15,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Young DA/HAN strain rats were submitted to an equilibrium test consisting in maintaining equilibrium upon a rotorod rotating at 10 or 20 rpm. They were either intact or lesioned, the lesion consisting in destruction of the inferior olivary complex (IOC) by 50-95 mg/kg i.p. administration of 3-acetylpyridine (3-AP) at day 15, followed, 2 to 4 h later, by i.p. injection of niacinamide (300 mg/kg). All the 3-AP-treated animals included in this study were completely lesioned, the extent of the lesion being estimated by both the response of the rats to harmaline and histological controls at the end of the experiments. The IOC lesioned rats were either naive (tested at one given day) or trained every day (10 trials per day); among the latters, some were trained before and after the lesion, the others being trained either before or only after. Control rats were submitted to the same training schedule. Both quantitative (time during which the animals maintained the equilibrium upon the rotating rod) and behavioral data (strategy used by the animals to maintain equilibrium) were obtained. The results demonstrate that, compared to those of controls rats, the quantitative and behavioral scores of the IOC lesioned animals were altered. Comparison of naive and trained animals shows that the impairment of the equilibrium behavior is not only due to the ataxia provoked by the IOC lesion but is also due to cognitive deficits. However, prelesion training facilitates the acquisition of a more efficient postlesion equilibrium behavior. From these results, it can be concluded that the olivo-cerebellar pathway is involved in the adaptation of motor behavior to the environmental conditions.
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PMID:Effects of lesion of the inferior olivary complex in learning of the equilibrium behavior in the young rat during ontogenesis. I. Total lesion of the inferior olive by 3-acetylpyridine. 859 79

The multi-needling in rows acupuncture is created by professor HAN Jing-xin, in which the cutaneous region, muscle region and meridian are involved in treatment in terms of the depth of disease and the location of treatment. The multi-needling in rows acupuncture on the cutaneous region is for the disorders of the cutaneous superficial area, characterized as shallow puncturing to the skin layer. The multi-needling in rows acupuncture on the muscle region is for the disorders of the muscle region, characterized as needling the muscle regions with the multiple meridians involved, but without the meridian distributions concerned. The multi-needling in rows acupuncture on the meridian is used at the meridian points in terms of the meridian disorders and Zang fu disorders. The multi-needling in rows acupuncture for meridian disorders is applied to treat the local disorders on the running course of the meridian. The multi-needling in rows acupuncture for Zang fu disorders is used to treat the relevant Zang fu disorders in terms of the running course of the meridian, in which, the multi-needling in rows acupuncture at the Back-shu points is used specially for the disorders of the thoracic and abdominal organs and systems with the disturbance of the autonomic nerves included; the multi-needling in rows acupuncture at the three meridians in occipital region is specially for vertigo and ataxia induced by the cerebella disorders.
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PMID:[Multi-needling in rows acupuncture created by professor HAN Jing-xian]. 2299 97