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Query: UMLS:C0004134 (ataxia)
 15,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The paper is concerned with the development and specification of diagnostic approaches to patients with the title pathology. 168 patients with vascular syndromes of cervical osteochondrosis were under observation. According to the readings of ultrasound echocardiography and ultrasound double scanning, the patients were distributed into two groups: with occlusions and hemodynamically significant stenoses (from 50 to 99%) in the vertebral arteries, and without hemodynamically significant stenoses. On comparison of these two groups of patients with the disease clinical picture the first group patients demonstrated the signs of static or dynamic ataxia of varying gravity, thus allowing confirmation of the existence of the compression form of the vertebral artery syndrome--vertebrobasilar insufficiency. The authors have elaborated a complex of the treatment measures for patients with vascular syndromes of spinal osteochondrosis, including the use of medicamentous and nontraditional means (manual therapy, acupuncture), providing a possibility of carrying out successful conservative therapy. The role of vegetative formations located in the cervical part of the spine in regulation of the cerebral blood flow has been revealed.
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PMID:[The diagnosis and treatment of patients with the vascular syndromes of cervical osteochondrosis]. 216 27

A complex study was carried out on the vestibular disorders in 60 transport workers with cervical osteochondrosis in order to determine their incidence and character. The workers' age was from 20 to 60 and a length of service as drivers of transport vehicles - from 3 to 16 and even more years. The vestibular system was studied with regard to spontaneous nystagmic manifestations, the state of stato-kinetics, via experimental rotation and caloric provocations. Changes were observed in space-time perception after the provocation, rheographic hemodynamic changes and serum-biochemical deviations in organism. With the X-ray studies on the cervical segment of the spine, various manifestations of cervical osteochondrosis were found in 40.3 per cent of the subjects observed. The predominating changes were in the region of C4-C7 (in 29.2%). Two-three segpents were affected in the majority of the patients. Uncovertebral arthorosis, narrowing of the intervertebral foramina were found as well as osteophytes of the bodies of the vertebrae, etc. Those manifestations correlated with the vestibular disorders of the respective side, confirmed via rheography (bi- and fronto-mastoid). The vestibular deviations were reduced to dynamic ataxia - positive Romberg test (75.8%), deviations in the gait (57.9%), tendency to hyperreflexia, particularly for the horizontal-rotatory substrates of the vestibular analyzers. The vestibular dysfunction was clearly outlined with the juxtaposition of the data with those of the control group of subjects selected from the patients with functional deviations. Valuable conclusions were drawn concerning the medical-occupational fitness of the transport workers as well as concerning traffic safety.
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PMID:[Vestibular function in female transport workers with cervical osteochondrosis]. 660 23

Ataxia caused by a focal compression of the cervical spinal cord was diagnosed in four young standardbred trotting horses. Diagnosis was verified by myelography. Changes in the cervical vertebral column were studied using microradiographic and histologic methods. In the vertebrae involved, there was irregularity of the cartilaginous growth zone, cracks with a loose fragment and disturbance in the enchondral ossification. These changes resemble osteochondrosis. Porous appearance in lateral and ventral funiculi as well as mural calcified plaques in the small vessels of the white matter were found in the spinal cord.
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PMID:Osteochondrotic changes in the vertebrae of four ataxic horses suffering from cervical vertebral malformation. 667 37

A lesion in the cervical region of a 14-month-old Belgian gelding with severe ataxia was suspected. Necropsy revealed symmetric focal cartilage defects compatible with osteochondrosis of the occipital condyles and atlanto-occipital dysplasia. To our knowledge this is the first equine report of symmetrical osteochondrosis of the occipital condyles causing neurologic signs.
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PMID:Osteochondrosis of the occipital condyles and atlanto-occipital dysplasia in a Belgian horse. 1470 85

A red deer herd of 150 mixed-age hinds, 48 stags and 102 weaners was identified as severely copper deficient during an observational study of 15 deer farms in the lower North Island of New Zealand during 1992 and 1993. Severe lameness was observed in nine weaners in 1992 (8.8% prevalence) and 15 in 1993 (12% prevalence). Typical abnormalities included swollen hocks and carpal joints and outward rotation of hind legs with hocks touching. At postmortem examination, there were epiphyseal fractures of the femoral head, severe degenerative arthropathy of the coxo-femoral joints and erosions of cartilage in many other limb joints. Osteochondrosis was confirmed histologically. Concurrently, three adult hinds and one adult stag developed into-ordination typical of enzootic ataxia which was confirmed histologically. Blood and liver copper concentrations in untreated affected weaner deer ranged from undetectable to 16.0 micromol/l (mean 7.6 micromol/l) and 25 to 53 micromol/kg (mean 39 micromol/kg), respectively. Mean blood copper concentrations in unaffected weaners in March 1992 and 1993 were 5.3 micromol/l and 4.4 micromol/l, respectively. The mean blood copper concentration in seven hinds in September 1992, prior to onset of clinical signs of enzootic ataxia, was 1.5 micromol/l (range 1.0-2.4 micromol/l). At other times of the year, mean blood copper concentrations ranged up to 12.5 micromol/l in adults and 8.9 micromol/l in weaners before treatment began in 1993. Pasture analyses showed copper contents of 6-11 ppm in 11 samples collected during 1992 and 1993. Sulphur ranged from 0.18 to 0.37%, molybdenum from 0.51 to 3.56 ppm and iron from 130 to 2886 ppm. These measurements supported a diagnosis of secondary copper deficiency. Supplementation with oral oxidised copper wire particles was undertaken from December 1992, resulting in an improvement in blood copper concentrations in some classes of deer. No further clinical abnormalities have been observed.
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PMID:Osteochondrosis, skeletal abnormalities and enzootic ataxia associated with copper deficiency in a farmed red deer (Cervus elaphus) herd. 1603 12

The first deer farms were established in New Zealand about 30 years ago. Extensive studies on trace elements in sheep and cattle have resulted in clarification of the requirements of those species and the development of protocols to diagnose and prevent deficiencies. In contrast, there have been very few studies conducted with deer. This review summarises information available on trace element nutrition of deer and concludes that, in New Zealand, cobalt (Co), vitamin B12, selenium (Se) and iodine (I) deficiencies are of lesser importance than copper (Cu), which can have a significant impact on deer health and performance. However, on individual farms, Se and I deficiency may cause significant production losses if not managed appropriately. There are no reports of production limitations caused by Co deficiency. Copper deficiency manifests itself as clinical disease, namely enzootic ataxia and osteochondrosis. Growth responses to Cu supplementation have only been reported in 2/11 trials and were not predicted from low serum and/or liver Cu concentrations. On the basis of clinical signs of Cu deficiency, the proposed reference ranges used to predict Cu status from serum Cu concentrations (micromol/l) are: 5, deficient; 5-8, marginal and; 8, adequate; and for liver Cu concentrations (micromol/kg fresh tissue) are: 60, deficient; 60-100, marginal and; 100, adequate. Copper supplementation strategies based on Cu-EDTA injections, Cu-oxide needles or the application of Cu to pasture are effective at increasing Cu status for varying periods. More recent research suggests that alternative forage species that have a high Cu content (10 mg/kg dry matter (DM), may play a role in the prevention of Cu deficiency.
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PMID:Trace element metabolism, dietary requirements, diagnosis and prevention of deficiencies in deer. 1603 81