Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004134 (ataxia)
 15,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A review of the literature shows that long-lasting neurological complications of eclampsia are rare, but that, when present, they frequently involve visual function. Two patients are reported, whose symptomatology suggested damage to the posterior region of both cerebral hemispheres. The first patient showed a Balint's syndrome with complete inability to perceive more than one object at a time, erratic gaze movements and optic ataxia. After a year and half a marked improvement was observed. The second patient presented with severe of dyscalculia, spatial memory disorders, constructional apraxia and mild aphasia. She recovered completely in one year. This symptomatology might result from ischemic lesions in the watershed area between the territories of the middle and posterior cerebral arteries, the underlying mechanism being the compression of the posterior cerebral artery against the tentorium, caused by edema.
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PMID:[Neuropsychological study of long-term cerebral complications of eclampsia (author's transl)]. 103 34

Sinal thrombosis, intracerebral bleeding, cerebral edema, and cerebral vasospasm are typical neurological complications in pre- and eclampsia. Hemolysis, elevated liver enzyme, and low platelet (HELLP) syndrome is a rare, severe complication of pre-eclampsia. We present the case of a 33-year-old woman with HELLP syndrome. After a cesarean section, generalized epileptic seizure occurred and intubation was necessary due to sustained unconsciousness. Despite magnesium therapy, bilateral hemodynamic ischemic infarctions and narrowing of the circle of Willis were visible on MRI, and vasospasm of all large basal cerebral arteries was confirmed by cerebral angiography and transcranial Doppler sonography. During the following 2 weeks, the cerebral vasospasm resolved with application of high-dose methyl prednisolone and nimodipine. After extubation, the patient initially suffered from mild psychosyndrome and ataxia but recovered completely after 3 months. The HELLP syndrome may be complicated by cerebral vasospasm with subsequent hemodynamic strokes. Combined treatment with magnesium, corticosteroids, and nimodipine can be recommended. In our case, this regimen led to resolution of the cerebral vasospasm and complete clinical recovery.
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PMID:[Cerebral vasospasms with hemodynamic infarctions as a complication of HELLP syndrome]. 1464 14

Abetalipoproteinemia is a rare metabolic disorder that causes disturbed lipid absorption with consequent hypocholesterolaemia and liposoluble avitaminosis. The broad spectrum of presentations includes malabsorption, failure to thrive and acanthocytosis in children, while later in life expected manifestations include coagulopathy, myopathy, retinitis pigmentosa, peripheral neuropathy, hyporeflexia and ataxia. These neurological complications stem from demyelination secondary to vitamin E deficiency. Another complication is reduced fertility in women. In the event of a successful conception, issues arise in vitamin supplementation, the mainstay of treatment of abetalipoproteinemia. The skilful clinician must master the delicate balance between the teratogenic effects on the fetus of over as well as under replacement of vitamins, pregnancy complications such as premature rupture of membranes and eclampsia, and, finally, maternal complications such as corneal ulcers. We describe the management of a patient ranging from pubertal growth to bearing a successful spontaneous pregnancy with an outcome of a completely healthy mother and child.
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PMID:A successful spontaneous pregnancy in abetalipoproteinemia: Amsterdam or the art of vitamin replacement? 2548 86