Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004134 (ataxia)
 15,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The diagnosis of meningo-radiculitis of unknown etiology was posed on a adult Caucasian male patient, based on clinical and biological symptoms offered since 1991, February (CSF: lymphocytic with hyperproteinosis). The patient had stayed in different bilharzia endemic zones. Confronted with a lack of improvement, even an aggravation and facing an appearance of a pyramidal symptom of the limbs, mostly at left, with ataxia preventing walking, one admitted the patient several times to do biological and radiological tests. They confirmed the troubles at the level of the CSF, already above mentioned; the MRI showed a hypersignal at the low dorso-lumbar level and at the terminal cone without any sign of tumoral processus, associated to an abnormal contrast at the level of meninges. All of that revealed a significant aspect of a meningo-myelo-radiculitis. In front of the various negative sero-bacteriological, viral, parasitic test, of the unresults of the research of any systemic symptom, one decided to perform a neurosurgical intervention to get a biopsy. So was revealed the presence of ovoid elements PAS+with a lateral spur and parasitic aspect. Consequently the diagnosis of bilharziosis was established. A cure of Praziquantel has been prescribed: 3 tablets/day for 10 days, and four more cures at an interval of one month, all of them associated to a long term corticotherapy. Any diminution of the dosis entailed an increase of the painful symptomatology. Because of the perennial posterior cordal painful symptom, the patient has shown a depressive reaction.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Developmental aspects of a bilharziasis caused by Schistosoma mansoni]. 813 34

Symptoms management in multiple sclerosis is an integral part of its care. Accurate assessment and addressing the different symptoms provides increased quality of life among patients with multiple sclerosis. Multiple sclerosis symptoms may be identified as primary, secondary, or tertiary symptoms. Primary symptoms, such as weakness, sensory loss, and ataxia, are directly related to demyelination and axonal loss. Secondary symptoms, such as urinary tract infections as a result of urinary retention, are a result of the primary symptoms. Tertiary symptoms, such as reactive depression or social isolation, are a result of the social and psychological consequences of the disease. Common multiple sclerosis symptoms include fatigue and weakness; decreased balance, spasticity and gait problems; depression and cognitive issues; bladder, bowel, and sexual deficits; visual and sensory loss; and neuropathic pain. Less-common symptoms include dysarthria and dysphagia, vertigo, and tremors. Rare symptoms in multiple sclerosis include seizures, hearing loss, and paralysis. Symptom management includes nonpharmacological methods, such as rehabilitation and psychosocial support, and pharmacological methods, ie, medications and surgical procedures. The keys to symptom management are awareness, knowledge, and coordination of care. Symptoms have to be recognized and management needs to be individualized. Multiple sclerosis therapeutics include nonpharmacological strategies that consist of lifestyle modifications, rehabilitation, social support, counseling, and pharmacological agents or surgical procedures. The goal is vigilant management to improve quality of life and promote realistic expectations and hope.
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PMID:Therapeutics for multiple sclerosis symptoms. 2142 63