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Query: UMLS:C0004134 (ataxia)
 15,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A botulinum toxin from ensiled poultry litter which caused a major outbreak of bovine botulism was characterised as type C1. The litter produced transient ataxia when fed to two experimental calves and the clinical signs were accompanied by a transient appearance of serum toxin. Type C1 toxin was demonstrated in muscle tissues which had been taken during the outbreak from an affected animal with high circulating serum toxin, and held frozen for seven months. Clostridium botulinum type C organisms were demonstrated in faeces from another affected animal and also in kidney tissue from a third animal. These observations have implications for the diagnosis and management of future outbreaks of botulism and for the potential health risk from the meat of affected animals.
Vet Rec 1989 May 27
PMID:Type C botulism in cattle being fed ensiled poultry litter. 275 62

Cattle and sheep, grazed successively on the same pasture and given the same supplementary feeding, developed ataxia and several animals became recumbent. Three cattle died within two weeks and the worst affected sheep were killed for laboratory examination. The supplementary diet which consisted largely of a distillery by-product, malt culms, was submitted for mycological examination and fed to two housed lambs. Aspergillus clavatus was cultured from the culms, and both the affected sheep and the housed lambs showed cerebrospinal degenerative changes. The clinical signs and neuropathology were closely similar to a mycotoxicosis, attributed to A clavatus, which is seen infrequently in cattle in France, Bulgaria, South Africa and China.
Vet Rec 1989 Feb 11
PMID:A fodder mycotoxicosis of ruminants caused by contamination of a distillery by-product with Aspergillus clavatus. 292 87

Combinations of detomidine (mean dose rate 13 micrograms/kg) and butorphanol (mean dose rate 26 micrograms/kg) were used to sedate 61 horses for a variety of surgical or diagnostic procedures in general equine practice. Three horses were sedated on more than one occasion. The degree of sedation was graded from 3 to 0 (deep sedation to no effect) and any side effects were recorded. Forty-three per cent of the horses were graded 3, 46 per cent were graded 2, 8 per cent were graded 1 and 3 per cent were graded 0. Bradycardia and ataxia were the major side effects. The combination was judged to be effective and safe for use in general practice. In 56 horses (92 per cent) the necessary procedure was carried out under excellent conditions and in only one horse was the degree of sedation considered to be totally unsatisfactory.
Vet Rec 1988 Oct 08
PMID:Detomidine-butorphanol sedation in equine clinical practice. 305 22

This study, initiated in June 1987, describes the epidemiology of bovine spongiform encephalopathy (BSE), a recently described novel neurological disease of domestic cattle first identified in Great Britain in November 1986. Records suggested that the earliest suspected cases occurred in April 1985. There was variability in the presenting signs and the disease course, but the majority of cases developed behavioural disorders, gait ataxia, paresis and loss of bodyweight; pruritus was not a predominant sign. The form of the epidemic was typical of an extended common source in which all affected animals were index cases. The use of therapeutic or agricultural chemicals on affected farms presented no common factors. Specific genetic analyses eliminated BSE from being exclusively determined by simple mendelian inheritance. Neither was there any evidence that it was introduced into Great Britain by imported cattle or semen. The study supports previous evidence of aetiological similarities between BSE and scrapie of sheep. The findings were consistent with exposure of cattle to a scrapie-like agent, via cattle feedstuffs containing ruminant-derived protein. It is suggested that exposure began in 1981/82 and that the majority of affected animals became infected in calfhood.
Vet Rec 1988 Dec 17
PMID:Bovine spongiform encephalopathy: epidemiological studies. 321 47

Three kittens in a litter of Persian cats showed, from the age of eight weeks, tremor, ataxia, dysmetria, progressive weakness and emaciation. Cytoplasmic vacuolation was observed in neurons, mesenchymal and epithelial cells of tissues taken post mortem. The alpha-mannosidase activity of brain tissue of one cat tested was 4.8 per cent of control values and the urine of two cats contained large amounts of mannose-rich oligosaccharides.
Vet Rec 1988 Apr 09
PMID:Mannosidosis in a litter of Persian cats. 338 51

Six cases of accidental salinomycin poisoning in horses are described. The horses were fed a contaminated ration and presented clinical signs which were extremely varied in nature and severity. However, the range of signs, including anorexia, colic, weakness and ataxia bore similarities to those described in horses poisoned with the related ionophore monensin. Other similarities became apparent in serum biochemical profiles of the clinical cases. Although ionophore toxicity is rarely reported in horses they appear to be particularly susceptible, and it should therefore be considered as a differential diagnosis of digestive upsets or locomotory disorders at establishments where ionophore-treated feeds are used therapeutically in other species.
Vet Rec 1987 Aug 08
PMID:Salinomycin poisoning in horses. 367 48

Atlanto-occipital fusion is a rare bony anomaly due to the failure of the developing arches of the first cervical vertebra to separate from the occiput. It may be associated with compressive myelopathy and must therefore be considered in the differential diagnosis of ataxia in the young animal. This report reviews the embryological development of the region and reports the findings in two cases of fusion in the calf.
Vet Rec 1987 Jan 10
PMID:Atlanto-occipital fusion and ataxia in the calf. 382 31

Between 1976 and 1981 a specific neurological disorder of sheep was observed in Ghana. It was encountered on eight properties on some of which it was responsible for losses of up to 72 per cent of the sheep stock in some years. The condition affected mainly adult ewes, and was characterised clinically by a brief period of ataxia, followed by paresis prostration and death in four to five days. Morphological examination of nine affected animals revealed significant lesions only in the central nervous system. These consisted of oedema of the intracellular glial compartment and bilateral, sometimes symmetrical, foci of spongy transformation, malacia and haemorrhage in the grey matter of the brain stem, cerebellum and spinal cord. The aetiology of ataxia/paresis syndrome was not determined but some possibilities are discussed in the context of other naturally occurring and experimental focal malacic disorders in animals.
Vet Rec 1985 Jan 26
PMID:Ataxia/paresis syndrome of sheep in West Africa associated with bilateral multifocal cerebrospinal poliomalacia. 397 53

Six circus lions (Panthera leo) showed neurological and gastrointestinal signs after consuming casualty broiler chickens. Signs included ataxia, hindlimb paralysis and recumbency. Neurological examination of two affected males showed paralysis of extraocular muscles, fixed dilated pupils and inability to swallow. Replacement fluids and antibiotics were given and Clostridium botulinum type C antitoxin was found in serum samples. Type C antitoxin was not then available and therapy was started in one lioness with guanidine hydrochloride. Convulsions were controlled by diazepam but this animal died. One of the two males was given type C antitoxin; both were given anabolic steroids. All the remaining animals made slow recoveries over varying periods; one lion was recumbent for 41 days. No lion developed respiratory paralysis; other animals which had consumed the chickens remained healthy. Aspects of the treatment of botulism in animals are discussed.
Vet Rec 1985 Jul 20
PMID:Diagnosis and treatment of botulism in lions. 404 82

An outbreak of paresis occurred on a small isolated stud farm in July 1980. Of the 42 horses on the stud, infection was confined to a group of nine in-foal mares and their foals and eight other horses which were either housed together at night or grazed adjacent pastures. Eight mares and two geldings developed ataxia or paresis and one mare died. Equid herpesvirus 1 was isolated from 17 animals and serological studies confirmed that 24 of 26 animals sampled had experienced infection.
Vet Rec 1981 Dec 12
PMID:An outbreak of paresis in mares and geldings associated with equid herpesvirus 1. 628 Mar 66


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