Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0004093 (asthenia)
 2,650 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A cross sectional study on the diagnostic and therapeutic practices of health staff and mothers with regard to fever was carried out in the urban area of Brazzaville from the 12th to the 20th of April 1997. 390 children were included in the sample. Children were aged under five years, had suffered from fever 15 days prior to the survey and were treated at home or in a health centre with the most currently used drugs against malaria, results of the questionnaire indicated that those symptoms best recognised by mothers are fever (85.8%), asthenia (79.9%), chills (21.1%), vomiting (25.1%) and diarrhoea (10.9%). Chloroquine is the most used drug at home (66%) and amodiaquine (34.5%) in health centres. Drugs are mainly supplied by private drugstores (67.9%) and street vendors (19.1%). Management of fever requires proper training of health staff and good communication between health personnel and the target population.
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PMID:[Management of child fever in the battle against malaria in Brazzaville]. 1201 65

A cross-sectional study on the diagnostic and therapeutic practices of health staff and mothers with regards to carrying for children's fever was carried out from February 27 to March 16, 1995, in the rural district of Boko. The sample was comprised of 630 children aged less than 5 years old, having suffered from fever within the past 15 days and who were treated either at home or in a local health centre with a drug most presently used against malaria. The results compiled from the responses to the questionnaire have shown that the most frequently cited symptoms by mothers are fever (57.8%), asthenia (51.7%), vomiting (10.6%), chills (7.3%) and diarrhea (7.3%). Chloroquine is the most utilised drug at home (61%) and anti-malaria injections are the most frequently used drugs in health centres (51.7%). The medicine is mainly supplied by public drugstores and pharmacies (47.8%) and street vendors (43.2%). Proper management of a fever requires adequate training of health staff and a good level of communication between health workers and their target populations.
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PMID:[Management of children's fever at home in a rural area of Boko (Congo-Brazzaville)]. 1496 16

An unprecedented epidemic of chikungunya virus (CHIKV) infection recently started in countries of the Indian Ocean area, causing an acute and painful syndrome with strong fever, asthenia, skin rash, polyarthritis, and lethal cases of encephalitis. The basis for chikungunya disease and the tropism of CHIKV remain unknown. Here, we describe the replication characteristics of recent clinical CHIKV strains. Human epithelial and endothelial cells, primary fibroblasts and, to a lesser extent, monocyte-derived macrophages, were susceptible to infection and allowed viral production. In contrast, CHIKV did not replicate in lymphoid and monocytoid cell lines, primary lymphocytes and monocytes, or monocyte-derived dendritic cells. CHIKV replication was cytopathic and associated with an induction of apoptosis in infected cells. Chloroquine, bafilomycin-A1, and short hairpin RNAs against dynamin-2 inhibited viral production, indicating that viral entry occurs through pH-dependent endocytosis. CHIKV was highly sensitive to the antiviral activity of type I and II interferons. These results provide a general insight into the interaction between CHIKV and its mammalian host.
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PMID:Characterization of reemerging chikungunya virus. 1760 50