Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0003969 (vitamin C deficiency)
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Human Gene/Protein
claudin-12 11.3
hSVCT1 11.0
SLC23A1 10.8
SLC23A2 10.7
SVCT2 10.7
ADAMDEC1 10.7
SVCT1 10.3
PG-Lb 10.1
gamma-butyrobetaine hydroxylase 10.0
ugd 9.9
autosomal recessive) 9.5
IL-17D 9.3
1alpha(OH)ase 9.3
proline hydroxylase 9.2
ribosomal protein S6 kinase 1 9.2
4E-BP2 9.2
periaxin 9.2
butyrobetaine 8.8
iron regulatory protein 1 8.7
Maltase 8.4
ZO-2 8.3
flavin-containing monooxygenase 8.2
TET3 8.2
Galactosyltransferase 8.1
heme-binding protein 8.0
ELK1 8.0
stomatin 7.8
Prolyl hydroxylase 7.8
PSEN1 7.8
lysyl hydroxylase 7.7
regucalcin 7.7
P35 7.6
Occludin 7.5
aldolase B 7.4
NADPH-cytochrome P-450 reductase 7.2
NF-E2-related factor 2 7.2
P40 7.1
tropoelastin 6.9
LCAT 6.8
prolyl 4-hydroxylase 6.8
fructokinase 6.8
PHD2 6.7
MKK6 6.7
period 3 6.7
aldehyde reductase 6.7
TET2 6.7
Insulin-like growth factor I 6.6
Apaf-1 6.6
fruitless 6.5
UDP-glucuronyltransferase 6.5
GRP94 6.4
TET1 6.4
hexosaminidase A 6.4
IL-11 6.4
delta-aminolevulinic acid dehydratase 6.4
alpha1-acid glycoprotein 6.3
transketolase 6.3
cytochrome P-450 6.3
MCT1 6.3
Haptoglobin 6.3
B12 6.2
matrix Gla protein 6.2
prolidase 6.2
transcobalamin II 6.2
IGFBP-1 6.1
UDP-glucuronic acid 6.1
apolipoprotein A1 6.1
leucine aminopeptidase 6.0
HDL2 5.9
Ferritin 5.9
ferrochelatase 5.8
Lipoprotein lipase 5.8
methionine synthase 5.8
GLUT2 5.8
p52 5.7
Acid phosphatase 5.7
Hepcidin 5.7
period 2 5.7
4E-BP1 5.6
ceruloplasmin 5.6
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Disease
Pantothenic acid deficiency 15.6
vitamin C deficiency 15.6
Metaphyseal osteopathy 14.1
scurvy 13.9
fructosuria 11.6
Gingival hypertrophy 11.5
cheilosis 11.2
Pyridoxine deficiency 10.9
dysbasia 10.8
Primary osteoporosis 10.6
tyrosinosis 10.5
Muscle degeneration 10.4
Schamberg's disease 10.4
Bury 10.2
vitamin B deficiency 10.1
beriberi 10.0
hypovitaminosis 9.6
paranoid personality disorder 9.6
gum disease 9.1
Brown tumor 9.1
pellagra 8.9
oxalosis 8.8
vitamin B6 deficiency 8.8
riboflavin deficiency 8.4
vitamin E deficiency 8.4
thiamine deficiency 8.2
petechiae 8.1
gingivostomatitis 8.1
dyschondroplasia 8.1
hereditary fructose intolerance 8.0
Growth failure 8.0
Barlow 7.9
cardiac overload 7.9
marasmus 7.8
hemorrhagic diathesis 7.8
sicca syndrome 7.7
lens opacity 7.6
kwashiorkor 7.5
emotional disorder 7.5
tobacco abuse 7.4
gingivitis 7.4
Bateman 7.4
tyrosinemia 7.4
abruptio placentae 7.3
vitamin A deficiency 7.2
dentinogenesis imperfecta 7.2
glossitis 7.2
epulis 7.2
acrodermatitis enteropathica 7.2
acute osteomyelitis 7.2
cerebral thrombosis 7.1
purpura 7.1
hyperkeratosis 7.0
nutritional disorder 7.0
platelet disorder 6.9
Disorder 6.9
renal osteodystrophy 6.9
xerophthalmia 6.7
Testes 6.7
periostitis 6.7
postherpetic neuralgia 6.6
keratosis 6.6
osteomalacia 6.6
folate deficiency 6.5
Zinc deficiency 6.5
macrocytic anemia 6.4
hypophosphatasia 6.4
osteodystrophy 6.3
megaloblastic anemia 6.3
vitamin K deficiency 6.3
aphthous stomatitis 6.3
Diabetic foot 6.3
gastrointestinal infection 6.3
genetic hypertension 6.3
cheilitis 6.3
rickets 6.2
joint effusion 6.2
malnutrition 6.2
methylmalonic acidemia 6.2
OHD 6.1
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Symptom
Localized pain 10.9
inanition 10.2
cardiovascular impairment 8.9
menometrorrhagia 8.4
limb pain 7.2
halitosis 6.4
bone pain 6.0
decreased appetite 5.4
tingling 5.3
asthenia 5.3
lethargy 5.2
arthralgia 5.1
exertional dyspnea 4.9
anorexia 4.7
pallor 4.3
Ill 4.2
knee pain 4.2
myalgia 4.0
fatigue 3.8
weakness 3.4
shortness of breath 3.3
collapse 3.2
hepatomegaly 3.1
hypotonia 3.1
starvation 3.0
erythema 3.0
chest pain 2.6
syncope 2.5
dyspnea 2.4
nausea and vomiting 2.4
thinning 2.2
back pain 2.1
sleepiness 2.0
exhaustion 1.9
ataxia 1.7
pain 1.5
tremor 1.5
nausea 1.1
overweight 1.0
diarrhea 0.8
abdominal pain 0.7
seizures 0.3
anesthesia -0.1
Drug
Lycium fruit 14.1
Ascorbic Acid 11.0
Diethylpropion 10.6
Iron dextran 10.1
ascorbate 9.6
Mazindol 8.8
Epoetin alfa 8.0
Epoetin alfa 7.4
IL-11 6.5
Vitamin B12 6.4
Camp 6.1
Vitamin A 5.7
vitamin E 5.6
niacin 5.3
pyridoxal phosphate 5.3
BH4 5.1
Glutathione 4.2
FAD 4.2
Vitamin E 4.0
Histamine 3.2
Dial 3.1
Indomethacin 3.0
lysine 2.8
THF 2.6
ABC 2.5
NADH 2.2
Gel 1.8
ampicillin 1.6
Monit 1.5
caffeine 1.2
Dermatol 0.6
Enzyme
UDP-N-acetylglucosamine 4-epimerase 11.9
GLO 10.7
gamma-butyrobetaine hydroxylase 10.3
cystathionine gamma-synthase 8.1
glycerol 3-phosphate dehydrogenase 8.0
4-hydroxyphenylpyruvate dioxygenase 7.8
lysyl hydroxylase 7.7
fructokinase 7.1
flavin-containing monooxygenase 7.1
lactonase 6.8
prolidase 6.7
aldehyde reductase 6.7
aldehyde reductase 6.6
ECH 6.6
aldehyde reductase 6.6
prolyl hydroxylase 6.4
transketolase 6.3
sucrase 6.0
leucine aminopeptidase 6.0
methionine synthase 5.9
methionine synthase 5.8
ferrochelatase 5.8
delta-aminolevulinic acid dehydratase 5.8
ALA synthase 5.6
demethylase 5.5
lysyl oxidase 5.4
ceruloplasmin 5.3
heme oxygenase 5.2
dopamine beta-hydroxylase 5.2
alpha-glucosidase 5.2
6-phosphogluconate dehydrogenase 5.1
6-phosphogluconate dehydrogenase 5.1
3-hydroxy-3-methylglutaryl coenzyme A reductase 5.1
alpha-mannosidase 5.1
glucose-6-phosphatase 5.0
invertase 5.0
alpha-galactosidase 4.9
succinic dehydrogenase 4.9
CPR 4.9
aconitase 4.9
tryptophan hydroxylase 4.9
hexosaminidase 4.8
chondroitinase 4.6
cholesterol acyltransferase 4.6
acid phosphatase 4.6
chondroitinase 4.5
glutathione reductase 4.4
thioredoxin reductase 4.4
diamine oxidase 4.4
asparaginase 4.2
myosin light chain kinase 4.2
beta-glucosidase 4.2
collagenase 4.1
beta-glucosidase 4.0
papain 4.0
aldose reductase 3.9
UDP-glucuronosyltransferase 3.9
pyruvate dehydrogenase 3.9
pyruvate dehydrogenase 3.9
lipoprotein lipase 3.9
succinate dehydrogenase 3.6
cathepsin D 3.6
alkaline phosphatase 3.5
glyceraldehyde-3-phosphate dehydrogenase 3.5
glyceraldehyde-3-phosphate dehydrogenase 3.5
alcohol dehydrogenase 3.5
glyceraldehyde-3-phosphate dehydrogenase 3.4
IKK 3.4
tyrosine hydroxylase 3.4
DNA methyltransferase 3.4
NADPH oxidase 3.3
pyruvate dehydrogenase 3.2
glutathione peroxidase 3.2
glyceraldehyde-3-phosphate dehydrogenase 3.2
NADPH oxidase 3.2
diaphorase 3.1
hyaluronidase 3.0
glyceraldehyde-3-phosphate dehydrogenase 3.0
ribonuclease 3.0
ribonuclease 2.9
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Compound
Gulonate 12.8
Gulonate 12.3
L-Gulonolactone 12.1
Benzanthrone 11.4
Diethylpropion 11.2
threonate 10.7
Ascorbic acid 10.1
Methazolamide 10.0
Dehydroascorbic acid 9.6
2,4,6-trimethylpyridine 9.4
2,4,6-trimethylpyridine 9.3
Pyridinoline 9.2
trimethyllysine 9.2
MMD 8.7
Fenfluramine 8.2
Antipyrine 8.0
TET 7.9
TET 7.9
hexuronic acid 7.6
hexuronic acid 7.5
5H-pyrido[4,3-b]indole 7.5
hexuronic acid 7.5
hexuronic acid 7.5
Trp-P-2 7.4
Betamethasone 7.2
Tetrahydrobiopterin 7.2
D-glucuronate 7.2
Metyrapone 7.1
Metyrapone 7.1
DLT 7.1
Thiamine 7.0
Palmitic acid 6.6
Thiobarbituric acid 6.5
D-glucuronic acid 6.4
Vinblastine 6.4
Neomycin 6.3
Amlodipine 6.3
delta-aminolevulinic acid 6.2
25-hydroxycholecalciferol 6.0
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
oxalic acid 5.8
TDP 5.7
Collagenase 5.7
Vitamin A 5.7
UGA 5.6
Hydroxyproline 5.5
oxalic acid 5.5
proline 5.5
Carnitine 5.5
2-oxoglutarate 5.4
L-carnitine 5.3
Collagen 5.3
Thyroxine 5.1
PGA 5.0
chlorobenzene 5.0
aniline 4.9
Biotin 4.9
Clozapine 4.9
hydroxyindoleacetic acid 4.7
retinol 4.7
oxalate 4.6
Colchicine 4.6
FFA 4.6
DHA 4.6
DHA 4.5
25-dihydroxycholecalciferol 4.5
more...