Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
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Target Concepts:
Gene/Protein
Disease
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Query: UMLS:C0003969 (
vitamin C deficiency
)
625
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In guinea-pigs a diet which was deficient in ascorbic acid provoked neurogenic atrophy of the muscles, degeneration of the anterior horn motor cells and demyelination of the pyramidal tract. Muscles showed a decrease of cytochrome and
cytochrome c oxidase
. Subcutaneous haemorrhages were also found, particularly around the knee joints. The haemorrhages and the histopathology of the muscles and spinal cord were prevented by a high dosage of ascorbic acid. In animals with an
ascorbic acid deficiency
, histopathology of muscles and spinal cord were also prevented by L-cysteine, L-methionine and L-hydroxyproline. Subcutaneous haemorrhages were not prevented by these supplements.
...
PMID:Experimental amyotrophic lateral sclerosis in the guinea-pig. 398 Dec 16
