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Target Concepts:
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Query: UMLS:C0003969 (
vitamin C deficiency
)
625
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of dietary vitamin C on the reduction of
cytochrome c
and cytochrome P-450 by NADPH-cytochrome P-450 reductase was determined in guinea pig liver microsomes. Acute
vitamin C deficiency
decreased hepatic microsomal cytochrome P-450 content 21% and the rate of cytochrome P-450 reduction 66% without affecting
cytochrome c
reduction. However, the vitamin status of the animals did not affect the enhancement in cytochrome P-450 reduction produced by the addition of a type I substrate to the reaction mixture. The results suggest that
vitamin C deficiency
selectivity affects the transfer of electron from NADPH to cytochrome P-450 and that this effect does not result from a change in the spin state of cytochrome P-450.
...
PMID:NADPH-dependent reduction of cytochrome P-450 in liver microsomes from vitamin C-deficient guinea pigs: effect of benzphetamine. 628 11
