Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0003969 (
vitamin C deficiency
)
625
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
It has been suggested that early features of scurvy (fatigue and weakness) may be attributed to carnitine deficiency. Ascorbate is a cofactor for two alpha-ketoglutarate-requiring dioxygenase reactions (epsilon-N-trimethyllysine hydroxylase and
gamma-butyrobetaine hydroxylase
) in the pathway of carnitine biosynthesis. Carnitine concentrations are variably low in some tissues of
scorbutic
guinea pigs.
Ascorbic acid deficiency
in guinea pigs resulted in decreased activity of hepatic
gamma-butyrobetaine hydroxylase
and renal but not hepatic epsilon-N-trimethyllsine hydroxylase when exogenous substrates were provided. It remains unclear whether
vitamin C deficiency
has a significant impact on the overall rate of carnitine synthesis from endogenous substrates. Nevertheless, results of studies of enzyme preparations and perfused liver in vitro and of
scorbutic
guinea pigs in vivo provide compelling evidence for participation of ascorbic acid in carnitine biosynthesis.
...
PMID:Ascorbic acid and carnitine biosynthesis. 196 62
