Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0003873 (rheumatoid arthritis)
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Human Gene/Protein
HLA-DR4 protein 9.2
ZNF391 9.2
phospholipase D family, member 4 9.2
ankyrin repeat domain 38 9.2
WDFY family member 4 9.2
HLA-B alpha-chain 9.2
AURA17 9.2
TNFSF13b 9.2
FLJ11106 9.2
DKFZp667F0711 9.2
differentially expressed in FDCP 6 homolog 9.2
ra-a47 9.2
ZNF334 9.2
C6orf26 9.2
rheumatoid arthritis-related antigen RA-A47 9.2
FAM167B 9.2
PADI 1 9.2
Major histocompatibility complex, class I, B 9.2
TTC38 9.2
Peptidyl arginine deiminase, type IV 9.2
Chemokine C-C motif ligand 4 9.2
Major histocompatibility complex, class I, G 9.2
AURA1 9.2
HLA-DRbeta-chain 9.2
HLA DMA 8.6
Proprotein convertase subtilisin/kexin type 6 8.6
PADI4 8.6
OLIG3 8.6
C5orf30 8.6
peptidyl arginine deiminase type IV 8.5
cartilage glycoprotein-39 8.4
V-ATPase B2 subunit 8.2
CHCHD5 8.2
guanylate cyclase 1, soluble, alpha 2 8.2
ribosomal protein L23A 8.2
MHC class II HLA-DRB1 8.2
ATP6G 8.2
HLA-DRB1 protein 8.2
lectin, galactoside-binding, soluble, 3 8.2
serum amyloid A-like 1 8.2
MXRA7 8.2
V beta 5.5 8.2
GCP372 8.2
SPP24 8.2
KIAA1838 8.2
NPD014 8.2
AF4/FMR2 family, member 1 8.2
CHRNA7 protein 8.2
Rho GTPase-activating protein 12 8.2
HLA-DR beta1 8.2
Kelch-like protein 7 8.2
OR2H1 8.2
CD159c 8.2
C5orf17 8.2
Rheumatoid factor 8.2
CCP 8.2
ANKRD55 8.1
rheumatoid factor 8.1
CCP3 8.1
PIP4K2C 8.1
protein arginine deiminase 8.1
metastatic lymph node 51 8.0
CCP2 8.0
HLA DRB1 gene 7.9
DC32 7.9
HLA-DR beta 1 7.7
LRRC31 7.6
SAF-2 7.6
HIST1H2BC 7.6
Osteoclast-associated receptor 7.6
MRPS6 7.6
hexosaminidase D 7.6
platelet receptor for type III collagen 7.6
F-actin capping protein alpha-1 subunit 7.6
Phospholipase D4 7.6
craniofacial development protein 1 7.6
APOL6 7.6
PTP-HSCF 7.6
galactosidase, beta 1 7.6
Fc receptor-like 2 7.6
more...
Disease
Cricoarytenoid joint arthritis 9.2
Follicular occlusion triad 9.2
Penicillamine-induced myasthenia 9.2
Omarthritis 9.2
Radiation chimera 9.2
Anterior tibial compartment syndrome 9.2
Vertical overbite 9.2
Primary cutaneous immunocytoma 9.2
Rheumatic joint disease 9.2
Acute arthropathy 9.2
Macrophagic myofascitis 9.2
melanemia 9.2
Accelerated rheumatoid nodulosis 9.2
Early morning joint stiffness 9.2
Inflammatory polyarthritis 9.2
syndrome; cervical 9.2
Alphaviral infections 9.2
Subacute arthritis 9.2
Pulmonary Lymphomatoid Granulomatosis 9.2
Diffuse scleritis 9.2
rheumatoid arthritis 9.2
Diabetic scleredema 9.2
Senile scleral plaque 9.2
Rheumatoid neutrophilic dermatitis 9.1
Rheumatoid vasculitis 9.0
Rheumatoid lung 9.0
Rheumatoid nodulosis 9.0
Steinbrocker 8.9
Caplan's syndrome 8.8
Dysglobulinemia 8.6
Scleromalacia perforans 8.6
Early morning stiffness 8.6
palindromic rheumatism 8.6
Felty's syndrome 8.5
SLE arthritis 8.4
Ulnar drift 8.3
Subacromial bursitis 8.2
Nodular scleritis 8.2
Idiopathic bronchiectasis 8.2
Lactose intolerant 8.2
Pseudochylothorax 8.2
Drug-induced aplastic anemia 8.2
Cervicocranial syndrome 8.2
Secondary fibrositis 8.2
Chronic iridocyclitis 8.2
Allergic diarrhea 8.2
megalerythema 8.2
Amyloid tumour 8.2
Cutaneous mycobacterial infection 8.2
Mesenteric occlusion 8.2
Acute bacterial arthritis 8.2
Kelly syndrome 8.2
Other anaemias 8.2
NSAID-associated gastropathy 8.2
Systemic rheumatoid vasculitis 8.2
arthritis of the cervical spine 8.2
inflammatory joint disease 8.1
OASF 8.1
Erosive osteoarthritis 8.0
arthritis deformans 7.9
Peripheral ulcerative keratitis 7.9
IDDM6 7.8
Follicular bronchiolitis 7.8
psoriatic arthritis 7.6
Ulcerative stomatitis 7.6
OCTD 7.6
Proliferative synovitis 7.6
Non-caseating epithelioid cell granulomas 7.6
Anterior scleritis 7.6
Progression of rheumatoid arthritis 7.6
Synovial disorders 7.6
rheumatoidlike arthritis 7.6
endocrine or metabolic disease 7.6
Ulnar neuritis 7.6
Aqueous misdirection 7.6
Borderline lepromatous leprosy 7.6
pleurisy with effusion 7.6
synovitis 7.6
Jaccoud 7.5
IDDM13 7.4
more...
Symptom
Knee edema 9.2
Joint tenderness 8.9
swollen joints 8.5
Occipital headache 7.6
Abnormal sensation 7.6
polymyalgia 7.1
Restless sleep 6.9
Palmar erythema 6.9
impaired body balance 6.9
feeling of malaise 6.4
Axillary lymphadenopathy 6.4
Diffuse pain 6.4
Acute back pain 6.1
sense loss 5.9
gastrointestinal colic 5.8
Foot pain 5.7
Homan's sign 5.6
Grip strength decreased 5.6
Night pain 5.6
Radiating pain 5.6
finger pain 5.6
Pitting edema 5.5
cardiovascular disability 5.4
arthralgia 5.4
GI irritation 5.3
joint crepitus 5.2
jaundice of the skin 5.2
koilonychia 5.2
Musculoskeletal symptoms 5.1
cracked lips 5.1
ECG signs of myocardial ischemia 5.1
musculoskeletal impairment 4.9
metatarsalgia 4.9
Skin thickening 4.8
vaginal discomfort 4.8
skin impairment 4.8
joint stiffness 4.8
intestinal pain 4.6
epigastric distress 4.6
generalized pain 4.6
onychoschizia 4.6
intermenstrual pain 4.6
Flare 4.6
hand pain 4.5
Hyperflexion 4.5
Muscle tenderness 4.5
postpartum pain 4.5
Myokymia 4.4
Multiple symptoms 4.4
Pain at rest 4.4
Mild pain 4.4
General symptoms 4.3
abnormal taste 4.3
non-productive cough 4.3
Severe pain 4.2
pubic pain 4.2
Spastic paraparesis 4.2
Watery diarrhea 4.1
Pain and tenderness 4.1
Hesitancy 4.1
wrist pain 4.0
hip pain 3.9
dry eye 3.9
livedo 3.9
dry throat 3.8
neck pain 3.7
disturbed balance 3.7
musculoskeletal disability 3.7
loss of taste 3.7
Anterior knee pain 3.7
chronic back pain 3.5
No pain 3.5
stomach pain 3.4
Severe diarrhea 3.4
productive cough 3.4
nipple pain 3.4
nipple pain 3.4
dental pain 3.4
ankle pain 3.3
arm weakness 3.3
more...
Drug
Ecopladib 9.2
Fontolizumab 9.2
Tenovil 9.2
Cromoglicate lisetil 9.2
Tilomisole 8.8
Indometacin farnesil 8.6
Bucillamine 8.6
Abatacept 8.5
Iguratimod 8.5
Actarit 8.2
Alclofenac 8.1
Rimexolone 7.9
Tocilizumab 7.9
Lobenzarit disodium 7.8
Golimumab 7.8
Auranofin 7.7
Pentopril 7.6
Solganal 7.6
Pyrithioxine 7.6
Enlimomab 7.6
Amiprilose hydrochloride 7.6
Aristospan 7.6
Certolizumab pegol 7.6
Tenidap 7.6
Gold sodium thiomalate 7.6
Sulphasalazine 7.5
Romazarit 7.4
Adalimumab 7.4
Plaquenil 7.3
Plaquenil 7.3
Talniflumate 7.2
Pirazolac 7.2
Diftalone 7.2
Profenid 7.2
Pirprofen 7.1
Infliximab 7.1
Infliximab 7.1
Indoprofen 7.1
Lumiracoxib 7.1
Nabumetone 7.0
Anakinra 7.0
Zepelin 6.9
Dexamethasone palmitate 6.9
Mobic 6.9
Etodolac 6.9
Arava 6.9
Tiaprofenic acid 6.9
Fenoprofen calcium 6.8
Trocade 6.6
Aczone 6.6
Aminosalicylic Acid 6.6
Tiopronin 6.6
Aceclofenac 6.5
Mizoribine 6.5
Feprazone 6.5
Fenbufen 6.5
Acemetacin 6.5
Fenoprofen 6.5
Oxaprozin 6.4
CIA 6.4
Tolmetin sodium 6.4
L-Penicillamine 6.4
Dolobid 6.4
Platonin 6.3
Tolectin 6.3
Tenoxicam 6.3
Arresten 6.2
Alminoprofen 6.2
Rilonacept 6.2
BLyS 6.2
Thalomid 6.1
Alfacalcidol 6.0
Isoxicam 5.9
Fenclofenac 5.8
Valdecoxib 5.7
Celebrex 5.7
Lornoxicam 5.6
Arbaprostil 5.6
Feldene 5.6
Tepoxalin 5.6
more...
Enzyme
matrix metalloproteinase-15 7.6
EC 3.1.1.48 7.6
peptidylarginine deiminase 7.5
collagenase 3 5.8
dihydroorotate dehydrogenase 5.8
dihydroorotate dehydrogenase 5.8
MMP-3 5.5
neutrophil collagenase 5.5
aggrecanase-1 5.3
arginine deiminase 5.1
CYP39A1 5.1
dihydrolipoyl transacylase 4.9
cathepsin K 4.9
DHOdehase 4.8
EC 2.4.2.26 4.8
N-acetylglucosamine-6-sulfatase 4.6
AICAR transformylase 4.4
nicotinic acid mononucleotide adenylyltransferase 4.4
interstitial collagenase 4.3
GGTase-I 4.1
phosphoglucose isomerase 4.1
matrix metalloproteinase 10 4.1
DAP II 4.0
methylisocitrate lyase 4.0
LMT 4.0
caspase-5 4.0
histidyl-tRNA synthetase 4.0
homogentisate 1,2-dioxygenase 4.0
cathepsin S 4.0
acetylornithine aminotransferase 3.9
NADH kinase 3.9
collagenase 3.8
folylpolyglutamate synthetase 3.8
lysophospholipase D 3.8
caspase-5 3.7
macrophage elastase 3.6
cathepsin G 3.6
proteinase-3 3.6
TACE 3.6
matrix metalloproteinase 9 3.5
IKK 3.4
type III procollagen 3.4
enzyme X 3.4
LTC4 synthase 3.3
alliinase 3.3
Delta6-desaturase 3.3
cathepsin V 3.3
factor D 3.2
D-dopachrome tautomerase 3.2
thiopurine methyltransferase 3.1
neutrophil elastase 3.1
MMP 3.1
GalT 3.1
beta-1,4-galactosyltransferase 3.1
FucT 3.0
ceruloplasmin 3.0
TSP-1 3.0
adamalysin 2.9
elastase 2.9
p100 2.9
HCS 2.9
galactosylhydroxylysyl glucosyltransferase 2.8
SOR 2.8
methylenetetrahydrofolate reductase 2.8
methylenetetrahydrofolate reductase 2.8
C3b inactivator 2.8
CPN 2.8
MIP 2.7
dipeptidyl peptidase IV 2.7
sphingosine kinase 2.7
conjugase 2.7
thioredoxin reductase 2.7
indoleamine 2,3-dioxygenase 2.7
prostaglandin synthetase 2.6
cytidine deaminase 2.6
elongation factor (EF) 2.6
TGT 2.5
caspase-1 2.5
C3 convertase 2.5
thymidine phosphorylase 2.5
more...
Compound
C6H13N3O3 9.2
3-(4-chlorophenyl)-2-mercaptoacrylic acid 9.2
C6H13N3O3 9.2
Deoxynupharidine 9.2
C6H13N3O3 9.2
Agrimophol 9.2
C6H13N3O3 9.2
2-cyanopropanoic acid 9.2
C14H15N7 9.2
C6H13N3O3 9.2
C14H15N7 9.2
C6H13N3O3 9.2
C14H15N7 9.2
C6H13N3O3 9.2
C6H13N3O3 9.2
Hydroxychloroquine sulfate 8.6
HAQ 8.4
Leflunomide 8.3
L-Homocystine 8.2
C16H14O8 8.2
N-methylbenzohydrazide 8.2
4-methylphenylboronic acid 8.2
Pinoquercetin 8.2
C16H32 8.2
N-methylbenzohydrazide 8.2
Etanercept 7.8
Gingerenone A 7.6
Paramethasone 7.6
4-methylpentanamide 7.4
4-(4-methylphenyl)-4-oxobutanoic acid 7.4
CCP 7.3
Sinomenine 7.2
C16H32 7.2
Prinomide 7.2
C14H12N2O3 7.2
Aurothioglucose 7.2
Cimifugin 7.2
Oxaprozin 7.0
Tigogenin 6.9
Sinomenine hydrochloride 6.9
Tubeimoside I 6.9
Argininic acid 6.9
Prospidin 6.8
Tolmetin 6.8
Etoricoxib 6.7
Patuletin 6.6
Am 580 6.6
Wuweizisu C 6.6
C15H32 6.6
Aldophosphamide 6.6
Sulfasalazine 6.6
BSSG 6.5
2,4-pyrimidinediamine 6.5
Hydroxychloroquine 6.4
C11H13NO3 6.4
Demoxepam 6.4
Deltonin 6.4
C17H36 6.4
11H-indeno[1,2-b]quinoxalin-11-one 6.4
Methotrexate 6.4
ETN 6.3
LA 96 6.2
CCTP 6.2
3-azaspiro[5.5]undecane 6.2
2,3-heptanedione 6.2
C30H50 6.2
Fenoprofen 6.1
C17H16N2O2 6.1
2-butenamide 6.1
Scopolin 6.1
Budlein A 6.1
Diflunisal 6.0
Triamcinolone hexacetonide 5.9
Indocin 5.9
C6H10O4 5.9
4-methylbenzamide 5.9
Triptolide 5.9
Rofecoxib 5.9
CGP 52608 5.8
CZP 5.8
more...