Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0003873 (rheumatoid arthritis)
 53,068 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
cytokine 3552
Sep 3058
collagen 2619
TNF 2577
rheumatoid factor 2386
tumor necrosis factor 2056
IL-6 1832
ankylosing spondylitis 1627
Mol 1369
C-reactive protein 1228
HLA 1084
CD4 1013
TNF-alpha 998
IL-17 850
IL-1 819
type II collagen 700
IgA 689
IL-10 646
She 636
lymphoid 617
interleukin-6 610
ESR 570
CRP 521
lipopolysaccharide 519
IL-8 502
IFN 444
RANKL 443
IL-4 440
insulin 428
chemokine 428
HLA-DR 417
CCP 415
IL-2 404
interferon 403
DR4 402
tumor necrosis factor alpha 380
IFN-gamma 364
p38 354
Cytokine 350
CD20 343
HLA-DR4 328
DBA 322
CD8 320
MRI 309
HLA-DRB1 309
Tumor necrosis factor 307
glycoprotein 303
COX-2 301
LPS 301
major histocompatibility complex 292
gut 287
autoantigen 286
ACR 277
matrix metalloproteinase 275
MHC 257
interferon-gamma 254
collagenase 242
cyclooxygenase 241
Mal 233
albumin 231
CD28 230
MAPK 227
vascular endothelial growth factor 224
fibrinogen 222
IL-1 beta 216
Janus kinase 214
proteoglycan 213
alkaline phosphatase 212
p65 212
MMP-3 210
IL-23 205
serum albumin 205
CD25 204
cyclooxygenase-2 203
T cell receptor 202
hemoglobin 198
TCR 187
fibronectin 185
myeloperoxidase 185
TNF receptor 184
STAT3 183
granulocyte 181
Rheumatoid factor 179
interleukin-2 179
ERK 178
osteoprotegerin 177
MHC class II 177
DR1 174
thymus 174
TLR4 174
MMP-1 173
MTX 172
human leukocyte antigen 170
histone 170
JNK 168
ATP 167
RANK 164
stromelysin 161
STAT 154
Fas 152
superoxide dismutase 152
ICAM-1 152
IL-18 151
caspase-3 151
DRB1 148
ARA 148
IL-15 147
Pol 146
inducible nitric oxide synthase 146
IgE 145
PTPN22 144
MCP-1 144
macrophage colony-stimulating factor 144
PI3K 144
CD14 143
MMP-9 142
proteinase 3 138
metalloproteinase 138
HLA-B27 136
non-Hodgkin's lymphoma 135
membrane-bound 135
vimentin 133
CD40 130
adhesion molecule 128
vascular cell adhesion molecule-1 127
HLA class II 123
THP 123
lectin 122
GM-CSF 122
TGF-beta 120
catalase 119
interleukin 6 119
B27 118
fused 117
peroxidase 114
CIA 113
ERK1 112
polypeptide 112
CD80 112
IL-21 112
ferritin 110
MMP-13 106
AKT 106
p53 105
AP-1 104
CD86 104
mast cell 103
tartrate-resistant acid phosphatase 102
RANTES 102
interleukin-17 101
ANA 100
COX-1 99
VEGF 99
type I collagen 99
osteocalcin 98
nitric oxide synthase 98
DR3 98
mitogen-activated protein 97
CD44 96
JAK1 96
more...
Disease
rheumatoid arthritis 53068
arthritis 9593
systemic lupus erythematosus 5290
osteoarthritis 4387
autoimmune disease 2618
cancer 2486
multiple sclerosis 1753
synovitis 1733
ankylosing spondylitis 1711
psoriasis 1703
diabetes 1637
psoriatic arthritis 1441
osteoporosis 1302
vasculitis 1264
lupus 1256
inflammatory bowel disease 1136
Crohn's disease 1101
arthropathy 1093
PSS 1073
atherosclerosis 1049
lupus 944
tumor 923
asthma 871
polyarthritis 715
tuberculosis 714
rheumatism 652
cardiovascular disease 648
depression 605
hypertension 589
scleroderma 547
gout 529
arthrodesis 526
type 1 diabetes 523
lymphoma 476
dermatomyositis 463
ulcerative colitis 462
obesity 440
juvenile rheumatoid arthritis 433
PCC 415
amyloidosis 415
polymyositis 410
pneumonia 405
sepsis 399
anemia 390
fibromyalgia 385
sepsis 380
Epstein 375
Best 360
infectious diseases 352
connective tissue disease 350
periodontitis 344
Alzheimer's disease 329
sarcoidosis 327
DBA 323
interstitial lung disease 318
chronic disease 316
mixed connective tissue disease 315
SLE 311
leukemia 306
proteinuria 298
HIV 297
glomerulonephritis 296
Sjogren's syndrome 294
stroke 293
Mycobacterium 292
multiple myeloma 288
systemic disease 284
hepatitis 280
renal disease 277
rash 276
interstitial pneumonia 273
plaque 269
chronic pain 263
immunodeficiency 251
inflammatory joint disease 250
polymyalgia rheumatica 245
septic arthritis 241
myasthenia gravis 237
myocardial infarction 235
thrombocytopenia 234
Felty's syndrome 231
neutropenia 227
chronic obstructive pulmonary disease 224
heart failure 222
lung disease 219
Larsen 214
uveitis 213
spondyloarthropathy 202
celiac disease 202
Reiter's syndrome 201
Hodgkin's disease 199
renal failure 196
type 2 diabetes 195
encephalomyelitis 188
periodontal disease 187
AIDS 185
Wegener's granulomatosis 185
tenosynovitis 182
Graves' disease 176
colitis 175
atopic dermatitis 174
antiphospholipid syndrome 170
breast cancer 168
primary biliary cirrhosis 167
cirrhosis 165
Lupus 163
nephrotic syndrome 161
B-cell lymphoma 161
pulmonary fibrosis 158
myositis 157
lymphadenopathy 153
giant cell arteritis 151
hepatitis B 151
skin disease 150
neuropathy 148
coronary artery disease 146
cold 146
myelopathy 143
Parkinson's disease 143
non-Hodgkin's lymphoma 140
hepatitis C 140
virus infection 139
polyarteritis nodosa 138
Hashimoto's thyroiditis 138
HLA-B27 136
lupus nephritis 135
lymphoproliferative disorders 134
pericarditis 132
metabolic syndrome 129
ischemia 129
hypothyroidism 129
Infection 128
liver disease 128
congestive heart failure 128
influenza 128
carcinoma 128
graft-versus-host disease 124
dermatitis 123
bursitis 123
bronchiolitis 123
nephritis 122
vascular disease 122
lung cancer 121
schizophrenia 120
cryoglobulinemia 119
Steinbrocker 118
Still's disease 117
dyslipidemia 117
pemphigus 116
idiopathic pulmonary fibrosis 114
heart disease 113
melanoma 113
Raynaud's phenomenon 113
enthesitis 110
chronic renal failure 108
cytomegalovirus 108
Tumour necrosis 107
osteomyelitis 107
metastases 104
pyoderma gangrenosum 104
more...
Symptom
pain 3888
arthralgia 493
fatigue 434
swollen joints 334
diarrhea 242
dyspnea 221
weakness 212
headache 207
erythema 162
cough 160
low back pain 139
nausea 134
back pain 133
splenomegaly 129
abdominal pain 111
discomfort 98
discomfort 93
anesthesia 90
neck pain 87
collapse 85
cachexia 84
analgesia 82
vomiting 81
myalgia 70
dry eye 65
acute pain 61
seizures 57
respiratory distress 54
joint stiffness 48
Ill 47
hip pain 46
overweight 46
anorexia 45
knee pain 44
thinning 40
chest pain 39
shortness of breath 39
exertional dyspnea 38
numbness 37
dizziness 36
tinnitus 36
angina 36
shoulder pain 35
constipation 33
paresthesia 32
polymyalgia 26
nausea and vomiting 25
hoarseness 25
hepatosplenomegaly 25
sleepiness 25
hemoptysis 24
cancer pain 23
insomnia 22
wrist pain 22
sciatica 22
chills 21
livedo 21
dental pain 21
hemiplegia 21
hepatomegaly 21
starvation 21
fever of unknown origin 20
productive cough 20
exhaustion 20
neuralgia 19
paresis 19
epigastric pain 18
stridor 18
dysarthria 18
asthenia 18
sore throat 17
metatarsalgia 17
spasm 16
vertigo 15
heartburn 15
functional recovery 15
ataxia 15
syncope 15
alexithymia 14
chronic back pain 14
bone pain 13
distraction 13
Depressive symptoms 12
acidity 12
hypoproteinemia 12
tremor 11
clubbing 11
tingling 9
consciousness disturbance 9
night sweats 9
pelvic pain 9
non-productive cough 9
stomach pain 9
ankle pain 9
stigma 9
Stiffness 9
groin pain 9
facial pain 9
loss of taste 8
abnormal gait 8
pallor 8
intestinal bleeding 8
polyuria 8
rales 8
acute stress 8
decreased appetite 8
wheezing 8
leg edema 8
regurgitation 8
generalized pain 8
lethargy 8
thigh pain 8
hand pain 8
HSA 8
spasticity 7
Gastrointestinal symptoms 7
limb pain 7
heel pain 7
Flare 7
dystonia 7
hypothermia 7
menopausal symptoms 7
dysesthesia 7
skin irritation 6
agitation 6
Wind 6
orthopnea 6
chronic cough 6
abdominal discomfort 6
blurred vision 6
dysuria 6
Halo 6
Musculoskeletal symptoms 6
myoclonus 5
oliguria 5
acute abdomen 5
ophthalmoplegia 5
flushing 5
polydipsia 5
tense 5
Tenderness 5
paraparesis 5
Severe pain 5
orofacial pain 5
hopelessness 5
disturbed balance 5
arm pain 5
persistent cough 5
forgetfulness 4
Poor sleep 4
Foot pain 4
Postoperative pain 4
neck stiffness 4
torticollis 4
lightheadedness 4
elbow pain 4
Joint tenderness 4
snoring 4
pleuritic chest pain 4
GI irritation 4
more...
Drug
Dermatol 494
IL-2 406
IFN-gamma 349
Infliximab 259
Infliximab 259
Rituximab 208
CSF 201
Tocilizumab 167
Adalimumab 146
p75 130
Abatacept 122
Auranofin 119
CIA 113
lysine 100
IL-1ra 85
Cardiovasc 80
CTX 75
ROS 74
Indomethacin 68
vitamin E 64
ROC 62
Monit 54
Anakinra 54
Asthma 53
Sulphasalazine 46
ascorbate 43
Prednisolone 43
CTX 42
CTX 42
Gel 35
Dial 34
Prednisone 32
IL-11 32
Tacrolimus 31
MAP 31
IFN-beta 30
Golimumab 29
Nephron 26
Bucillamine 25
EPA 25
Gold sodium thiomalate 25
Etodolac 25
PTH 25
BLyS 25
G-CSF 24
Denosumab 24
Misoprostol 24
caffeine 23
Diclofenac sodium 23
Albumin 21
Nabumetone 21
ABC 20
Nephron 19
Certolizumab pegol 19
Histamine 18
Tenidap 18
Fragment 18
Voltaren 17
FLP 17
lactose 17
Tenoxicam 16
ENT 16
Leaf 15
Estrogens 15
Mizoribine 15
Iguratimod 15
Profenid 15
Asn 14
Hypaque 14
Methylprednisolone 14
Retinoic acid 14
Hypaque 14
Aceclofenac 13
CAM 13
Arava 12
Imatinib 12
DNase I 12
Fluorescein 12
Tiaprofenic acid 12
Bifidobacterium 12
Plaquenil 11
Tiopronin 11
ampicillin 11
CCL 11
Plaquenil 11
Campath 11
Campath 11
Lumiracoxib 11
Celebrex 11
NADH 10
Glycyrrhiza 10
Indoprofen 9
Check 9
Vioxx 9
Fluorescein 9
Tuberculin 9
Oxaprozin 9
Neoral 9
TAK 9
Fenoprofen 9
nitroglycerin 9
Spectrum 9
EE2 9
Nitric Oxide 8
Pirprofen 8
Ginger 8
Serum albumin 8
NBT 8
Valdecoxib 8
Novantrone 8
DPA 8
ADR 8
citric acid 8
niacin 7
Salicylate 7
Mutagen 7
ICI 7
Angiotensin II 7
ACT 7
NAG 7
THA 7
Fenbufen 7
Gleevec 6
Belatacept 6
Alanine 6
Bortezomib 6
MDS 6
Alclofenac 6
Orphan 6
CPR 6
GEO 6
Taxol 6
-deoxyadenosine 6
Bayer 6
Zileuton 6
Alliance 6
Nimesulide 6
Gelatin 6
Heme 6
Leucovorin 6
Bevacizumab 6
Simvastatin 6
Gastro 6
THF 6
PCP 5
PFT 5
Carbopol 934 5
Lovastatin 5
Belimumab 5
Glide 5
Dakar 5
Vitamin E 5
Efalizumab 5
Ranitidine 5
Deflazacort 5
Acemetacin 5
Rolipram 5
Adenosine deaminase 5
MRC 5
PDL 5
more...
Enzyme
mitogen-activated protein kinase 632
collagenase 424
focal adhesion kinase 313
ERK 302
peroxidase 302
MMP-3 266
alkaline phosphatase 212
superoxide dismutase 180
protein kinase 152
catalase 137
luciferase 135
trypsin 117
elastase 116
caspase-3 113
phospholipase A2 109
peptidylarginine deiminase 106
proteasome 97
cathepsin K 92
protein kinase C 89
IKK 85
glutathione peroxidase 82
alanine aminotransferase 73
lysozyme 73
reverse transcriptase 69
thrombin 66
ceruloplasmin 66
aspartate aminotransferase 66
acid phosphatase 64
lactate dehydrogenase 63
MEK 63
NADPH oxidase 61
caspase-1 61
MMP 61
neutrophil elastase 59
NADPH oxidase 57
ACS 57
NO synthase 54
MIP 54
urokinase-type plasminogen activator 50
phosphoglucose isomerase 50
calcineurin 50
plasmin 49
arginine deiminase 49
dihydroorotate dehydrogenase 47
dihydroorotate dehydrogenase 47
RNase 42
matrix metalloproteinase 9 42
beta-glucuronidase 42
RNase 41
ACE 39
ATPase 39
lipoxygenase 39
P-glycoprotein 38
pepsin 38
cathepsin G 37
APC 37
cathepsin B 37
hyaluronidase 36
phosphodiesterase 35
kallikrein 35
adenosine deaminase 35
hyaluronidase 34
phosphatidylinositol 3-kinase 34
adenosine deaminase 34
PARP 33
RNA polymerase 32
gamma-glutamyl transpeptidase 31
phospholipase C 30
dihydrofolate reductase 30
glutathione S-transferase 30
caspase-9 30
creatine kinase 30
DNase 30
interstitial collagenase 30
CD10 29
AMP-activated protein kinase 28
papain 27
phosphoinositide 3-kinase 26
thioredoxin reductase 26
renin 26
methylenetetrahydrofolate reductase 25
AST 25
methylenetetrahydrofolate reductase 25
MAP 24
glutathione reductase 23
enolase 23
granzyme B 23
xanthine oxidase 22
CYP3A4 22
tissue plasminogen activator 21
MDP 21
tryptase 21
matrix metalloproteinase 2 20
beta-galactosidase 20
AMPK 20
prostaglandin synthetase 19
transglutaminase 19
caspase-8 19
dipeptidyl peptidase IV 18
cathepsin D 17
aldehyde dehydrogenase 17
TACE 16
endonuclease 16
AMPK 16
thromboplastin 16
chymotrypsin 16
indoleamine 2,3-dioxygenase 15
transcriptase 15
CD13 15
glucose-6-phosphate dehydrogenase 14
CPT 14
NOS 14
neutrophil collagenase 14
ribonuclease 14
ribonuclease 14
CPT 13
chitinase 13
urease 13
CDR 13
CPT 13
cathepsin S 13
urease 13
type III procollagen 12
thyroid peroxidase 12
GSK 12
acetylcholinesterase 12
heme oxygenase 11
p100 11
adenylate cyclase 11
TSP-1 11
15-lipoxygenase 10
C3 convertase 10
hexosaminidase 10
thymidine phosphorylase 10
paraoxonase 10
MEKK1 10
BAL 10
prolyl hydroxylase 10
cytidine deaminase 10
aldehyde dehydrogenase 10
chymase 10
cdc2 9
monoamine oxidase 9
glyceraldehyde-3-phosphate dehydrogenase 9
thymidylate synthase 9
cathepsin L 9
histone acetyltransferase 9
glyceraldehyde-3-phosphate dehydrogenase 9
DNA polymerase 9
carbonic anhydrase 9
glyceraldehyde-3-phosphate dehydrogenase 8
tissue kallikrein 8
topoisomerase 8
topoisomerase 8
deoxyribonuclease 8
sphingosine kinase 8
deoxyribonuclease 8
glyceraldehyde-3-phosphate dehydrogenase 8
DNA methyltransferase 8
neuraminidase 8
more...
Compound
Clin 7593
Dec 3645
TNF 2577
DNA 1606
calcium 864
oxygen 747
Methotrexate 709
sodium 575
CCP 415
nitric oxide 357
DBA 322
DBA 322
DBA 322
water 313
arginine 298
glucose 295
iron 287
acetate 281
creatinine 274
phosphate 267
vitamin D 258
Etanercept 234
tyrosine 234
Hearts 223
Collagen 219
HAQ 216
PEG 203
sulfate 198
cysteine 185
zinc 178
His 178
MTX 172
ATP 167
Leflunomide 166
PGE2 166
galactose 159
hydrogen 159
BMC 159
leucine 154
lysine 146
serine 130
copper 130
salt 129
hyaluronic acid 125
THP 125
THP 125
nitrogen 123
PGE 116
Phe 112
cAMP 107
alanine 104
Cardiol 103
ANA 100
DPA 100
DPA 100
DPA 100
pyrimidine 100
DPA 100
ANA 100
DPA 100
pyrimidine 99
MTT 98
ASA 97
ethanol 94
GSH 93
GSH 93
tryptophan 92
ANCA 91
SDS 89
PEG 89
tryptophan 87
tryptophan 86
tryptophan 86
potassium 84
urea 83
CTX 75
EDTA 73
EDTA 73
Sulfasalazine 72
Celecoxib 70
Hydroxychloroquine 69
methionine 69
Cyclosporine 68
Gly 68
Indomethacin 67
Chloroquine 67
Chloroquine 67
PMA 66
titanium 66
Vitamin D 65
Asp 63
PMA 63
GlcNAc 63
selenium 63
bromide 63
CO2 62
retinoic acid 62
threonine 60
TOF 59
MCP 58
ACS 58
acetic acid 58
ACTH 57
iodine 57
ACS 57
FK506 54
H2O2 50
Triptolide 49
ethyl acetate 48
AMP 47
homocysteine 45
methanol 45
Tumor Necrosis Factor 44
Ibuprofen 43
superoxide radical 42
uridine 42
Prednisolone 42
proline 41
BMD 40
salicylic acid 40
silver 39
Naproxen 38
MDA 38
NADPH 38
TSH 38
Curcumin 38
NADPH 37
PGA 37
APAP 37
Sinomenine 37
Optimal 36
Azathioprine 36
ammonium 36
Thyroid 36
Dexamethasone 36
MEK 35
Insulin 34
Dial 34
propionic acid 34
Collagenase 34
propionic acid 34
celastrol 34
COX 33
6-12 33
Prednisone 33
hydroxide 33
DHA 33
prostaglandin E1 33
glutamate 32
CIT 32
Wellcome 31
nitrate 31
nicotinamide 31
neopterin 31
phosphorus 31
ADP 30
folinic acid 30
DTPA 30
chromate 30
prostacyclin 29
more...